Results 41 to 50 of about 26,695 (224)

Leukoencephalopathy, a Frequent Complication After High‐Dose Methotrexate in Treatment of Osteosarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Methotrexate‐associated leukoencephalopathy is poorly documented in osteosarcoma. Since 2007, our institution has monitored osteosarcoma patients with sequential magnetic resonance imaging (MRI) and neuropsychological evaluations during treatment and follow‐up.
Sandra Raimbault, Jean Louis Amegnizin, Audrey Longaud, Brice Fresneau, Nathalie Gaspar, Pablo Berlanga, Virginie Kieffer, Anne Maraval, Lucy Metayer, Christelle Dufour, Dominique Valteau‐Couanet, Pierre Brugieres, Blanche Bapst, Laurence Brugieres   +13 more
wiley   +1 more source

Ly6C+ Inflammatory Monocyte Differentiation Partially Mediates Hyperhomocysteinemia-Induced Vascular Dysfunction in Type 2 Diabetic db/db Mice.

Arteriosclerosis, Thrombosis and Vascular Biology, 2019
OBJECTIVE Hyperhomocysteinemia (HHcy) is a potent risk factor for diabetic cardiovascular diseases. We have previously reported that hyperhomocysteinemia potentiates type 1 diabetes mellitus-induced inflammatory monocyte differentiation, vascular ...
Pu Fang, Xinyuan Li, Huimin Shan, J. Saredy, Ramón Cueto, Jixiang Xia, Xiaohua Jiang, Xiaofeng Yang, Hong Wang   +8 more
semanticscholar   +1 more source

Impact of age at first visit on glycolipid metabolism, bone metabolism, and fertility potential in patients with Klinefelter syndrome

Andrology, EarlyView.
Abstract Background Classic Klinefelter syndrome (KS) is characterized by one extra X chromosome (47, XXY), leading to hypergonadotropic hypogonadism and higher risk of alterations in glycolipid homeostasis, cardiovascular diseases, and low bone mineral density. Most frequently, KS is diagnosed in adulthood because of infertility.
Giordana Ferraioli, Andrea Graziani, Noemi Sagone, Andrea Di Nisio, Massimo Iafrate, Fabrizio Dal Moro, Alberto Ferlin, Andrea Garolla   +7 more
wiley   +1 more source

Case report: Rare variants in the MTRR gene, 66GG and 524TT cause hyperhomocysteinemia and folic acid deficiency linked to schizophrenia

Frontiers in Psychiatry
We present an adult patient with schizophrenia who was later found to have hyperhomocysteinemia, a condition that increases the risk of several diseases, due to a deficiency in folic acid.
Chih-Chia Huang, Chih-Chia Huang
doaj   +1 more source

Avascular Necrosis and Minimal Trauma Fractures in Telomere Biology Disorders

Clinical Genetics, EarlyView.
Avascular Necrosis (AVN) and Minimal Trauma Fractures (MTF) cause significant morbidity in people with Telomere Biology Disorders (TBDs). They occur more frequently in young patients and in those with autosomal recessive (AR) or X‐linked recessive (XLR) than in autosomal dominant (AD) genotypes.
Arman M. Niknafs, Neelam Giri, Marena R. Niewisch, Sharon A. Savage   +3 more
wiley   +1 more source

Implications of inflammation and sex in lower extremity arterial disease

European Journal of Clinical Investigation, EarlyView.
The graphical abstract illustrates the role of inflammation and sex‐related differences in lower extremity artery disease (LEAD). Key inflammatory biomarkers associated with LEAD include C‐reactive protein (CRP), fibrinogen, interleukin‐6 (IL‐6), and D‐dimer, which contribute to vascular inflammation and atherosclerotic plaque formation in lower limb ...
Katja Schnidrig, Manovriti Thakur, Aleksandra Tuleja, Sarah Maike Bernhard, Heidi Noels, Drosos Kotelis, Marc Schindewolf, Yvonne Döring   +7 more
wiley   +1 more source

Emodin Rescued Hyperhomocysteinemia-Induced Dementia and Alzheimer’s Disease-Like Features in Rats

International Journal of Neuropsychopharmacology, 2018
Background Hyperhomocysteinemia is an independent risk factor for dementia, including Alzheimer’s disease. Lowering homocysteine levels with folic acid treatment with or without vitamin B12 has shown few clinical benefits on cognition.
Peng Zeng, Yan Shi, Xiao-Ming Wang, Li Lin, Yan-Jun Du, Na Tang, Qun Wang, Ying-Yan Fang, Jian-Zhi Wang, Xinwen Zhou, Youming Lu, Q. Tian   +11 more
semanticscholar   +1 more source

Hyperhomocysteinemia is associated with the risk of venous thromboembolism in patients with mental illness: a case-control study

Frontiers in Psychiatry
ObjectiveThe risk of venous thromboembolism in patients with mental illness has been insufficiently addressed. This study aimed to assess the correlation between hyperhomocysteinemia and venous thromboembolism prevalence among this population ...
Jiaoyan Wang, Jiaoyan Wang, Yingchun Zhang, Keming Ren, Yeping Li, Kejing Ying   +5 more
doaj   +1 more source

Incidence of hyperhomocysteinemia and MTHFR C677T polymorphism among young patients with acute myocardial infarction [PDF]

Journal of Medical Biochemistry, 2009
Hyperhomocysteinemia is considered an independent risk factor for premature cardiovascular disease. Mutation MTHFR C677T reduces the activity of methylene tetrahydrofolatereductase and may cause hyperhomocysteinemia.
Beletić Anđelo, Mirković Duško, Antonijević Nebojša, Đorđević Valentina, Šango Violeta, Jakovljević Branko, Peruničić Jovan, Ilić Mirka, Vasiljević Zorana, Majkić-Singh Nada   +9 more
doaj  

Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in burning mouth syndrome patients with macrocytosis

Journal of Dental Sciences, 2021
Background/purpose: Macrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study evaluated whether 46 burning mouth syndrome (BMS) patients with macrocytosis had significantly higher frequencies of anemia, hematinic ...
Ying-Tai Jin, Yu-Hsueh Wu, Yang-Che Wu, Julia Yu-Fong Chang, Chun-Pin Chiang, Andy Sun   +5 more
doaj   +1 more source