Results 41 to 50 of about 20,640 (292)

Brain injury due to persistent hyperinsulinemic hypoglycemia of infancy [PDF]

, 2007
A
De Visschere, Pieter, Senepart, Maarten, Seynaeve, Patrick, Vanrietvelde, Frederik   +3 more
core   +2 more sources

Insulin-induced glycosylphosphatidylinositol (GPI) binding to red cell membrane proteins [PDF]

Journal of the Serbian Chemical Society, 2002
In this work GPI binding to membrane proteins from erythrocytes of insulinoma patients for whom prolonged hyperinsulinism and hypoglycemia were characteristic, as well as from normal erythrocytes incubated with supraphysiological concentrations of ...
NENAD TOMASEVIC, VESNA NIKETIC, MILAN NIKOLIC   +2 more
doaj   +3 more sources

18F-6-Fluoro-l-Dopa PET/CT Imaging of Congenital Hyperinsulinism.

Journal of Nuclear Medicine, 2021
Congenital hyperinsulinism is characterized by persistent hypoglycemia due to inappropriate excess secretion of insulin resulting in hyperinsulinemic hypoglycemia.
L. States, J. C. Davis, Steven M Hamel, Susan A. Becker, H. Zhuang   +4 more
semanticscholar   +1 more source

Pasireotide treatment for severe congenital hyperinsulinism due to a homozygous ABCC8 mutation

Annals of Pediatric Endocrinology & Metabolism, 2021
ABCC8 and KCJN11 mutations cause the most severe diazoxide-resistant forms of congenital hyperinsulinism (CHI). Somatostatin analogues are considered as secondline treatment in diazoxide-unresponsive cases.
C. Mooij, C. Tacke, M. V. van Albada, W. Barthlen, H. Bikker, K. Mohnike, M. Oomen, A. S. V. van Trotsenburg, N. Zwaveling-Soonawala   +8 more
semanticscholar   +1 more source

A new familial form of a late-onset, persistent hyperinsulinemic hypoglycemia of infancy caused by a novel mutation in KCNJ11. [PDF]

, 2017
The ATP-sensitive potassium channel (KATP) functions as a metabo-electric transducer in regulating insulin secretion from pancreatic β-cells. The pancreatic KATP channel is composed of a pore-forming inwardly-rectifying potassium channel, Kir6.2, and a ...
Ferrara, Christine, German, Michael, Gitelman, Stephen, Long, Roger, Yang, Shi-Bing, Yang, Yen-Yu   +5 more
core   +1 more source

Modern therapeutic aspects in two cases of congenital hyperinsulinism [PDF]

Romanian Journal of Pediatrics, 2020
In this article we will present the therapeutic and clinical aspects found in the case of two pediatric patients diagnosed with congenital hyperinsulinism.
Cristian Minulescu, Dana Spirea
doaj   +1 more source

Birth weight and diazoxide unresponsiveness strongly predict the likelihood of congenital hyperinsulinism due to a mutation in ABCC8 or KCNJ11

European Journal of Endocrinology, 2021
Objective Mutations in the KATP channel genes, ABCC8 and KCNJ11, are the most common cause of congenital hyperinsulinism. The diagnosis of KATP-hyperinsulinism is important for the clinical management of the condition.
Thomas I. Hewat, D. Yau, Joseph C S Jerome, T. Laver, J. Houghton, B. Shields, S. Flanagan, K. Patel   +7 more
semanticscholar   +1 more source

Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells [PDF]

, 2017
ATP-sensitive potassium channels (K(ATP) channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, K(ATP) channels are essential for coupling glucose metabolism to insulin secretion.
Conway, Hannah, Emfinger, Christopher H., Moss, Jennifer B., Moss, Larry G., Nichols, Colin G., Remedi, Maria S., Wang, Yixi, Welscher, Alecia, Yan, Zihan   +8 more
core   +2 more sources

Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1-/- mouse model.

PLoS ONE, 2020
There is a significant unmet need for a safe and effective therapy for the treatment of children with congenital hyperinsulinism. We hypothesized that amplification of the glucagon signaling pathway could ameliorate hyperinsulinism associated ...
Mangala M Soundarapandian, Christine A Juliana, Jinghua Chai, Patrick A Haslett, Kevin Fitzgerald, Diva D De León   +5 more
doaj   +1 more source

Congenital hyperinsulinism in a newborn presenting with poor feeding

SAGE Open Medical Case Reports, 2022
Hyperinsulinemic hypoglycemia is a condition linked to several genetic, metabolic, and growth disorders in which there is dysregulated insulin secretion.
Kiran Mazloom, Pedro A Sanchez-Lara, Seth Langston, Katheryn Grand, Bahareh Schweiger   +4 more
doaj   +1 more source