Results 71 to 80 of about 20,640 (292)

Therapies and outcomes of congenital hyperinsulinism‐induced hypoglycaemia

Diabetic Medicine, 2018
Congenital hyperinsulinism is a rare disease, but is the most frequent cause of persistent and severe hypoglycaemia in early childhood. Hypoglycaemia caused by excessive and dysregulated insulin secretion (hyperinsulinism) from disordered pancreatic β ...
I. Banerjee, I. Banerjee, M. Salomon-Estebanez, M. Salomon-Estebanez, P. Shah, J. Nicholson, K. Cosgrove, M. Dunne   +7 more
semanticscholar   +1 more source

Continuous Glucose Monitoring Systems: Are They Useful for Evaluating Glycemic Control in Children with Hyperinsulinism?

Hormone Research in Paediatrics, 2020
Background: Effective treatment and close monitoring in children with congenital hyperinsulinism (HI) are important to prevent hypoglycemic-associated brain damage.
Arpana Rayannavar, O. Elci, Lauren M. Mitteer, Diva D. De León   +3 more
semanticscholar   +1 more source

Facilitators and barriers to establishing lactation among women with diabetes?

Diabetic Medicine, EarlyView.
Abstract Aim To identify the facilitators and barriers to establishing lactation among women with diabetes in pregnancy. Methods A qualitative descriptive study involving face‐to‐face semi‐structured interviews with 13 postpartum women. An inductive, data‐driven content analysis approach was utilised.
Denise McGuinness, Usha Daniel, Denise O. Brien   +2 more
wiley   +1 more source

Next-generation sequencing reveals deep intronic cryptic ABCC8 and HADH splicing founder mutations causing hyperinsulinism by pseudoexon activation [PDF]

, 2013
Copyright © 2013 The American Society of Human Genetics. Published by Elsevier Inc.Next-generation sequencing (NGS) enables analysis of the human genome on a scale previously unachievable by Sanger sequencing.
Akcay, T, Banerjee, I, Bas, F, Berberoglu, M, Caswell, Richard, Clayton, PE, Clayton, PT, Damhuis, A, Darendeliler, F, Ellard, Sian, Flanagan, SE, Green, Andrew, Guven, A, Hussain, K, Murphy, N, O'Sullivan, M, Ocal, G, Siklar, Z, Vianey-Saban, C, Weedon, Michael N., Xie, W   +20 more
core   +1 more source

The molecular mechanisms, diagnosis and management of congenital hyperinsulinism

Indian Journal of Endocrinology and Metabolism, 2013
Congenital hyperinsulinism (CHI) is the result of unregulated insulin secretion from the pancreatic β-cells leading to severe hypoglycaemia. In these patients it is important to make an accurate diagnosis and initiate the appropriate management so as to ...
Senthil Senniappan, Ved Bhushan Arya, Khalid Hussain   +2 more
doaj   +1 more source

Inheritance of a paternal ABCC8 variant and maternal loss of heterozygosity at 11p15 retrospectively unmasks the etiology in a case of Congenital hyperinsulinism

Clinical Case Reports, 2020
Advances in genomics and 18F‐DOPA PET‐CT imaging have transformed the management of infants with Congenital Hyperinsulinism. Preoperative diagnosis of focal hyperinsulinism permits limited pancreatectomy with improved clinical outcomes while knowledge of
Caroline M. Joyce, Jayne A. Houghton, Domhnall J. O’Halloran, Paula M. O’Shea, Susan M. O’Connell   +4 more
doaj   +1 more source

Obstructive sleep apnea is associated with impaired insulin clearance and hepatic insulin sensitivity in paediatric obesity

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Obstructive sleep apnea (OSA) affects up to 40% of children and adolescents with obesity and is linked to hyperinsulinism. However, the mechanisms underpinning this association remain unclear. The study aims to assess the three key determinants of hyperinsulinemia: insulin clearance, secretion, and sensitivity in paediatric patients with ...
Giuseppina Rosaria UMANO, Francesca Aiello, Giulia Rondinelli, Alessandra Salvati, Delfina Petrone, Maria Vittoria Sibillo, Raffaella D'Ausilio, Pierluigi Marzuillo, Anna Grandone, Grazia Cirillo, Domenico Tricò, Emanuele Miraglia del Giudice   +11 more
wiley   +1 more source

Successful use of long acting octreotide in two cases with Beckwith-Wiedemann syndrome and severe hypoglycemia [PDF]

, 2014
INTRODUCTION: Hyperinsulinism associated with Beckwith-Wiedemann syndrome (BWS) can occur in about 50% of cases, causing hypoglycemia of variable severity. Parenteral use of octreotide may be indicated if unresponsive to diazoxide.
Hiba Al-Zubeidi, Michael E Gottschalk, Ron S Newfield   +2 more
core   +1 more source

Congenital hyperinsulinism disorders: Genetic and clinical characteristics

American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 2019
Congenital hyperinsulinism (HI) is the most frequent cause of persistent hypoglycemia in infants and children. Delays in diagnosis and initiation of appropriate treatment contribute to a high risk of neurocognitive impairment.
Elizabeth Rosenfeld, A. Ganguly, Diva D. De León   +2 more
semanticscholar   +1 more source

Complexities in the medical management of hypoglycaemia due to congenital hyperinsulinism

Clinical Endocrinology, 2020
Congenital Hyperinsulinism (CHI) is a rare disease of hypoglycaemia but is the most common form of recurrent and severe hypoglycaemia causing brain injury and neurodisability in children.
C. Worth, D. Yau, Maria Salomon Estebanez, E. O'shea, K. Cosgrove, M. Dunne, I. Banerjee   +6 more
semanticscholar   +1 more source