Results 71 to 80 of about 14,238 (246)

Effect of a physical activity and healthy eating lifestyle intervention in pregnancy on fetal growth trajectories: The DALI randomised controlled trial

Pediatric Obesity, Volume 20, Issue 5, May 2025.
Summary Background Obesity during pregnancy is related to fetal overgrowth. Effective interventions that can mitigate this risk are needed. Objectives This study aimed to investigate the effect of a lifestyle intervention for pregnant women with obesity on fetal growth trajectories. Methods In the DALI trial, pregnant women with a body mass index ≥29.0 
Anna M. Dieberger, Mireille N. M. van Poppel, Gernot Desoye, David Simmons, Jürgen Harreiter, Roland Devlieger, Carmen Medina, Deborah A. Lawlor, Ahmed Elhakeem, on behalf of the DALI core investigator group, Gernot Desoye, David Simmons, Rosa Corcoy, Juan M. Adelantado Perez, Alexandra Kautzky‐Willer, Jürgen Harreiter, Elizabeth Mathiesen, Dorte M. Jensen, Lise Lotte T. Andersen, Fidelma Dunne, Annunziata Lapolla, Maria G. Dalfra, Alessandra Bertolotto, Mireille N. M. van Poppel, Judith G. M. Jelsma, Sander Galjaard, Ewa Wender‐Ozegowska, Agnieszka Zawiejska, David Hill, Roland Devlieger, Frank J. Snoek   +30 more
wiley   +1 more source

Congenital Hyperinsulinism

Pediatric Annals, 2017
Congenital hyperinsulinism is a rare disorder that commonly presents in the immediate postnatal period as persistent hypoglycemia. The condition is frequently resistant to medical therapies, and the genetic mutations implicated in the disorder can be predictive of response to therapy.
Elena, Minakova, Alison, Chu
openaire   +3 more sources

Hyperinsulinaemia in pregnancy and gestational outcomes: A case series

Journal of Metabolic Health, 2022
Background: Pathological insulin resistance in pregnancy is associated with an increased risk for complications such as gestational diabetes mellitus and pre-eclampsia.
Sylvia M. North, Catherine Crofts, Caryn Zinn   +2 more
doaj   +1 more source

Perspective on the Genetics and Diagnosis of Congenital Hyperinsulinism Disorders.

Journal of Clinical Endocrinology and Metabolism, 2016
CONTEXT Congenital hyperinsulinism (HI) is the most common cause of hypoglycemia in children. The risk of permanent brain injury in infants with HI continues to be as high as 25-50% due to delays in diagnosis and inadequate treatment.
C. Stanley
semanticscholar   +1 more source

A Five‐Year Journey to Diagnosis: Resolving Persistent Hypoglycemia Through Successful Insulinoma Resection—A Case Report

Clinical Case Reports, Volume 13, Issue 3, March 2025.
ABSTRACT Insulinoma is a rare functional pancreatic neuroendocrine tumor with an annual prevalence of 0.5–5 cases per million. It is characterized by excessive insulin secretion, leading to recurrent hypoglycemia, often diagnosed through Whipple's triad: hypoglycemic symptoms, documented low plasma glucose, and symptom resolution after glucose ...
Ankit Shrestha, Anup Pandey, Paleswan Joshi Lakhey, Biraj Baral, Aakash Pandit, Achyut Marahatta, Amisha Seth   +6 more
wiley   +1 more source

Asymptomatic Hyperinsulinaemic Hypoglycaemia

European Journal of Case Reports in Internal Medicine, 2020
Hypoglycaemia is rare in apparently well patients without drug-treated diabetes mellitus and warrants evaluation and management when Whipple’s triad is present.
Ana Ferreira, Mariana Serino Barbosa, Rita Coelho, Patrícia Lourenço   +3 more
doaj   +1 more source

The difficult management of persistent, non‐focal congenital hyperinsulinism: A retrospective review from a single, tertiary center

Pediatric Diabetes, 2020
Congenital hyperinsulinism (CHI) is a rare, heterogeneous disease with transient or persistent hypoglycemia. Histologically, focal, diffuse, and atypical forms of CHI exist, and at least 11 disease‐causing genes have been identified.
Amalie Greve Rasmussen, M. Melikian, E. Globa, S. Detlefsen, L. Rasmussen, H. Petersen, K. Brusgaard, A. H. Rasmussen, M. Mortensen, H. Christesen   +9 more
semanticscholar   +1 more source

Safety and Efficacy of DTX401, an AAV8‐Mediated Liver‐Directed Gene Therapy, in Adults With Glycogen Storage Disease Type I a (GSDIa)

Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.
ABSTRACT Glycogen storage disease type Ia (GSDIa) is a rare, life‐threatening, inherited carbohydrate metabolism disorder caused by glucose‐6‐phosphatase (G6Pase) deficiency, which is essential for glycogenolysis and gluconeogenesis. GSDIa management includes a strict medically prescribed diet that typically includes daily uncooked cornstarch doses ...
David A. Weinstein, Terry G. Derks, David F. Rodriguez‐Buritica, Ayesha Ahmad, María‐Luz Couce, John J. Mitchell, Rebecca Riba‐Wolman, Malaya Mount, Julieta Bonvin Sallago, Katalin M. Ross, Melanie M. van der Klauw, Foekje de Boer, Caroline van der Schaaf, Heather Saavedra, Miguel Martínez‐Olmos, Elvis Atanga, Asad Hosseini, Deepali Mitragotri, Eric Crombez   +18 more
wiley   +1 more source

Managing Hypoglycaemia in Patients With Insulinoma—A Tertiary Centre Experience and Review of the Literature

Clinical Endocrinology, Volume 102, Issue 3, Page 344-354, March 2025.
ABSTRACT The management of hypoglycaemia is pivotal in the care of patients with insulinoma. Blood glucose monitoring and regulation needs careful attention pre‐ and peri‐operatively for patients undergoing surgical resection and as part of the long‐term management for patients with inoperable or metastatic disease.
Sophie Howarth, Tak‐Wai Ho, James Wimbury, Ruth Casey   +3 more
wiley   +1 more source

Transient Neonatal Hypocortisolism in Neonates with Hypoglycemia – Coexistence or Cause?

Indian Journal of Endocrinology and Metabolism
Introduction: Infants born preterm, with low birth weight (LBW), or with perinatal stress are at high risk for neonatal hypoglycemia. Low cortisol levels have also been demonstrated in this group of neonates, which is often transient.
Sunetra Mondal, Lakshmi Nagendra, Amarta S. Chowdhury, Rajan Palui, Soumyadeep Biswas, Devdeep Mukherjee, Krishnendu Khan, Aritra Sengupta, Anupama Pandey   +8 more
doaj   +1 more source