Results 81 to 90 of about 20,887 (300)
Regulation of metabolism by miR-378 [PDF]
, 2014 The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression.
Carrer, Michele, Olson, Eric N.
core +1 more source
Therapies and outcomes of congenital hyperinsulinism‐induced hypoglycaemia
Diabetic Medicine, 2018 Congenital hyperinsulinism is a rare disease, but is the most frequent cause of persistent and severe hypoglycaemia in early childhood. Hypoglycaemia caused by excessive and dysregulated insulin secretion (hyperinsulinism) from disordered pancreatic β ...
I. Banerjee +7 more
semanticscholar +1 more source
PLoS ONE, 2020 Congenital hyperinsulinism (CHI) is a significant cause of hypoglycaemia in neonates and infants with the potential for permanent neurologic injury. Accurate calculations of the incidence of rare diseases such as CHI are important as they inform health ...
D. Yau +13 more
semanticscholar +1 more source
Acta Paediatrica, EarlyView.Neonatal outcomes among neonates of women with and without type 1 diabetes in Sweden from 2010 to 2022 by Goldberg A. et al. ABSTRACT Aim This register‐based study aimed to investigate differences in adverse neonatal outcomes between neonates born to mothers with and without type 1 diabetes in Sweden.
Alexandra Goldberg +3 more
wiley +1 more source
Pediatric Annals, 2017 Congenital hyperinsulinism is a rare disorder that commonly presents in the immediate postnatal period as persistent hypoglycemia. The condition is frequently resistant to medical therapies, and the genetic mutations implicated in the disorder can be predictive of response to therapy.
Elena, Minakova, Alison, Chu
openaire +3 more sources
A new familial form of a late-onset, persistent hyperinsulinemic hypoglycemia of infancy caused by a novel mutation in KCNJ11. [PDF]
, 2017 The ATP-sensitive potassium channel (KATP) functions as a metabo-electric transducer in regulating insulin secretion from pancreatic β-cells. The pancreatic KATP channel is composed of a pore-forming inwardly-rectifying potassium channel, Kir6.2, and a ...
Ferrara, Christine +5 more
core +1 more source
Medical Journal of Australia, EarlyView.Abstract Introduction Monogenic diabetes accounts for 2–5% of diabetes. Although its identification has substantial therapeutic implications, more than 80% of affected individuals are undiagnosed or misdiagnosed as having type 1 or 2 diabetes. This consensus statement reviews genetic testing for monogenic diabetes in adults and provides evidence‐based ...
Sunita MC De Sousa +10 more
wiley +1 more source
Clinical and Molecular Characterisation Of Hyperinsulinaemic Hypoglycaemia In Infants Born Small-For-Gestational Age [PDF]
, 2013 OBJECTIVE: To characterise the phenotype and genotype of neonates born small-for-gestational age (SGA; birth weight 6 months. Normoglycaemia on diazoxide
Arya, Ved Bhushan +6 more
core +1 more source
Congenital hyperinsulinism disorders: Genetic and clinical characteristics
American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 2019 Congenital hyperinsulinism (HI) is the most frequent cause of persistent hypoglycemia in infants and children. Delays in diagnosis and initiation of appropriate treatment contribute to a high risk of neurocognitive impairment.
Elizabeth Rosenfeld +2 more
semanticscholar +1 more source
Hormone Research in Paediatrics, 2020 Background: Effective treatment and close monitoring in children with congenital hyperinsulinism (HI) are important to prevent hypoglycemic-associated brain damage.
Arpana Rayannavar +3 more
semanticscholar +1 more source