Results 81 to 90 of about 14,238 (246)

Visual interpretation, not SUV ratios, is the ideal method to interpret 18F-DOPA PET scans to aid in the cure of patients with focal congenital hyperinsulinism.

PLoS ONE, 2020
IntroductionCongenital hyperinsulinism is characterized by abnormal regulation of insulin secretion from the pancreas causing profound hypoketotic hypoglycemia and is the leading cause of persistent hypoglycemia in infants and children.
Pradeep K Garg, Burton Putegnat, Lisa Truong, Courtney Reynolds, Irene Sanchez, Jonathan K Nedrelow, John Uffman, Stephen J Lokitz, Rachid Nazih, Sudha Garg, Paul S Thornton   +10 more
doaj   +1 more source

Possible New Strategies for the Treatment of Congenital Hyperinsulinism

Frontiers in Endocrinology, 2020
Objective Congenital hyperinsulinism (CHI) is a rare disease characterized by persistent hypoglycemia as a result of inappropriate insulin secretion, which can lead to irreversible neurological defects in infants. Poor efficacy and strong adverse effects
J. Sikimić, T. Hoffmeister, A. Gresch, Julia K. Kaiser, W. Barthlen, C. Wolke, I. Wieland, U. Lendeckel, P. Krippeit-Drews, M. Düfer, G. Drews   +10 more
semanticscholar   +1 more source

Hypoglycemia in CDG patients due to PMM2 mutations: Follow up on hyperinsulinemic patients

JIMD Reports, 2020
Background Phosphomannomutase 2 deficiency (PMM2‐CDG) is the most common congenital disorder of glycosylation (CDG). Hypoglycemia has been reported in various CDG including PMM2‐CDG.
Hossein Moravej, Ruqaiah Altassan, Jaak Jaeken, Gregory M. Enns, Carolyn Ellaway, Shanti Balasubramaniam, Pascale De Lonlay, David Coman, Saadet Mercimek‐Andrews, Peter Witters, Eva Morava   +10 more
doaj   +1 more source

Insulin Autoimmune Syndrome: A Chinese Expert Consensus Statement

AGING MEDICINE, Volume 8, Issue 1, February 2025.
ABSTRACT Insulin autoimmune syndrome (IAS) is a rare autoimmune disorder characterized by spontaneous hypoglycemia. The incidence of IAS is higher in East Asian populations compared to other populations. Delayed diagnosis and treatment can lead to recurrent hypoglycemia, significant glucose fluctuations, and adverse clinical outcomes, including life ...
Huabing Zhang, Ming Xia Yuan, Qi Pan
wiley   +1 more source

Nationwide survey of endogenous hyperinsulinemic hypoglycemia in Japan (2017–2018): Congenital hyperinsulinism, insulinoma, non‐insulinoma pancreatogenous hypoglycemia syndrome and insulin autoimmune syndrome (Hirata’s disease)

Journal of Diabetes Investigation, 2019
We aimed to investigate the nationwide incidence, treatment details and outcomes of patients with endogenous hyperinsulinemic hypoglycemia (EHH), including those with transient/persistent congenital hyperinsulinism (CHI), insulinoma, non‐insulinoma ...
Yuki Yamada, Kana Kitayama, Maki Oyachi, Shinji Higuchi, R. Kawakita, Y. Kanamori, T. Yorifuji   +6 more
semanticscholar   +1 more source

Association of polymorphism genes LPL, ADRB2, AGT and AGTR1 with risk of hyperinsulinism and insulin resistance in the Kazakh population

Biomedical Reports, 2020
Hyperinsulinism and insulin resistance are closely associated with several common diseases including type 2 of diabetes, cardiovascular diseases, and metabolic syndrome.
A. Shakhanova, N. Aukenov, Alma Nurtazina, M. Massabayeva, D. Babenko, M. Adiyeva, Nurlan Shaimardonov   +6 more
semanticscholar   +1 more source

Pediatric Neuroendocrine Tumors in Denmark: Incidence, Management, and Outcome From 1995 to 2020

Pediatric Blood &Cancer, Volume 72, Issue 2, February 2025.
ABSTRACT Background Neuroendocrine tumors (NETs), although rare, are considered one of the most common gastrointestinal and bronchopulmonary pediatric neoplasms. We aimed to determine the incidence, tumor characteristics, management, and outcome of NETs and explore the role of genetic predisposition, focusing on low and intermediate grade tumors ...
Mona P. Ankerstjerne, Sara Giovannoni, Lene G. Christensen, Sören Möller, Pernille Holmager, Ulrich Knigge, Mark B. Ellebaek, Mathias Rathe   +7 more
wiley   +1 more source

Prenatal exposure to maternal hypertension and higher body mass index and risks of neurodevelopmental and psychiatric disorders during childhood

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 2, Page 319-330, February 2025.
Combined exposure to maternal prepregnancy with high BMI and hypertension was associated with a higher risk of certain mental disorders than that of individual exposure alone. High BMI status modified the association between maternal hypertension and these offspring mental disorders synergistically.
Samson Nivins, Parvin Kumar, Xinxia Chen, Mika Gissler, Catharina Lavebratt   +4 more
wiley   +1 more source

Prevalence of Adverse Events in Children With Congenital Hyperinsulinism Treated With Diazoxide

Journal of Clinical Endocrinology and Metabolism, 2018
Context Diazoxide, the only U.S. Food and Drug Administration-approved drug to treat hyperinsulinemic hypoglycemia, has been associated with several adverse events, which has raised concerns about the safety of this drug.
A. Herrera, M. Vajravelu, Stephanie Givler, Lauren M. Mitteer, C. Avitabile, K. Lord, Diva D. De León   +6 more
semanticscholar   +1 more source

AGDMP1 alleviates insulin resistance by modulating heat shock protein 60‐mediated IRS‐1/AKT/GLUT4 pathway and adipose inflammation: A potential therapeutic peptide for gestational diabetes mellitus

The FASEB Journal, Volume 39, Issue 2, 31 January 2025.
Overview of the role and mechanism of AGDMP1 in GDM. AGDMP1 might bind to HSP60 to activate the IRS‐1/AKT/GLUT4 signaling pathway, and subsequently increase glucose uptake and insulin sensitivity in adipocytes. In addition, AGDMP1 could inhibit the HSP60‐induced production of inflammatory cytokines to reduce inflammation and macrophage accumulation in ...
Shanshan Wang, Yuting Zhang, Shiman Hu, Xueqi Bai, Jiamin Zhu, Runrun Hao, Yan Cao, Zhonghua Shi   +7 more
wiley   +1 more source