Results 61 to 70 of about 6,192 (214)

Incidence and risk factors of linezolid-induced hyperlactatemia in ICU patients: development and validation of a nomogram

European Journal of Medical Research
Background Blood lactate is a well-established prognostic indicator in critically ill patients, and hyperlactatemia significantly increases intensive care unit (ICU) mortality.
Bo Yun, Hemei Bu, Qinxue Wang, Yuanze Ma, Qiulun Lu, Yi Han   +5 more
doaj   +1 more source

Octanoic Acid‐Rich Enteral Nutrition Alleviates Sepsis‐Associated Metabolic Disorders by Suppressing White Adipose Tissue Browning in Mice

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Octanoic acid‐rich enteral nutrition enhances hepatic ketogenesis to decrease lactate accumulation in septic mice. This further blocks the lactate‐GPR81‐CTRP6‐p38 pathway, thereby suppressing pathological white adipose tissue browning and its subsequent hypermetabolic effects.
Chunliang Zheng, Xiaohua Li, Chungen Xing, Chun Cao   +3 more
wiley   +1 more source

The Effectiveness of Linezolid and Teicoplanin for Managing Infections After Burn Injuries: A Retrospective Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Gram‐positive infections in burn patients present significant treatment challenges. This study compared the efficacy and safety of linezolid vs. teicoplanin for managing such infections in a clinical setting. Methods We conducted a retrospective study involving 77 burn patients with confirmed Gram‐positive infections at ...
Abolfazl Zendehdel, Maryam Roham, Sanam Soltani, Amirali Jahanshahi, Somayeh Heidarizadi   +4 more
wiley   +1 more source

Evaluation of a rapid method for measuring lactate in the venous blood of ruminants

Veterinary Record, Volume 198, Issue 11, Page e503-e507, 30 May/6 June 2026.
Abstract Background In cattle and small ruminants, blood lactate can predict recovery and survival in various diseases. Increased lactate concentration is associated with an unfavourable‐to‐poor prognosis. Different mobile rapid lactate measurement devices have been explored in different animal species.
Viktoria Kichmann, Kathrin Büttner, Julia Blad‐Stahl, Henrik Wagner, Axel Wehrend   +4 more
wiley   +1 more source

High‐Dose L‐Serine Supplementation During Febrile Decompensation in SARS1 Deficiency: A Case Report and Review of the Literature

JIMD Reports, Volume 67, Issue 3, May 2026.
ABSTRACT Seryl‐tRNA synthetase 1 (SARS1) deficiency is a rare autosomal recessive disorder presenting with neurodevelopmental delay, deafness, cardiomyopathy, and fatal metabolic decompensation triggered by febrile episodes. While amino acid chronic supplementation is established, no guidelines exist for acute management. We report the case of a 9‐year‐
Victor Andrès Valle, Arnaud Wiedemnan, Eva Feigerlova, David Coelho, Elise Jeannesson, Irina Rotaru, Marc Merten, Alexandre Raharimanana, François Feillet, Jean‐Marie Ravel   +9 more
wiley   +1 more source

Antenatal Presentation of MRPS22‐Related Mitochondrial Disease Confirmed With Rapid Proteomics

JIMD Reports, Volume 67, Issue 3, May 2026.
ABSTRACT MRPS22‐related mitochondrial disease (MIM#611719) is a rare autosomal recessive disorder caused by defects in the mitochondrial ribosomal protein S22, a component of the small mitoribosomal subunit essential for mitochondrial translation. Of the few reported cases, most present antenatally with a severe phenotype, conveying a poor prognosis ...
Liana N. Semcesen, Megan Ball, Daniella H. Hock, Juliet Kaye, Aimee Woods, Lucas De Jong, MitoMDT Diagnostic Network for Genomics and Omics, David R. Thorburn, Aleksandra Filipovska, Michael T. Ryan, David A. Stroud, Diana Stojanovski, David Coman, Sean Murray, Ryan L. Davis, John Christodoulou, Suzanne C. E. H. Sallevelt, Roula Ghaoui, Cas Simons, Stefan J. Siira, Shanti Balasubramaniam, Alison G. Compton, Daniel G. MacArthur, Nicole J. Lake, Drago Bratkovic, Joy Lee, Maina Kava, Amanda Samarasinghe, Yoni Elbaum, Catherine Atthow, Pauline McGrath, Tegan Stait, Rocio Rius, Liana N. Semcesen, Megan Ball, Daniella Hock, Luke E. Formosa, Ellenore M. Martin, Madeleine Harris, John Christodoulou, David R. Thorburn, Alison G. Compton, David A. Stroud, Jan Liebelt   +43 more
wiley   +1 more source

Different Contribution of Splanchnic Organs to Hyperlactatemia in Fecal Peritonitis and Cardiac Tamponade [PDF]

, 2013
Background. Changes in hepatosplanchnic lactate exchange are likely to contribute to hyperlactatemia in sepsis. We hypothesized that septic and cardiogenic shock have different effects on hepatosplanchnic lactate exchange and its contribution to ...
Eleftheriadis, Anestis, Bracht, Hendrik, Jakob, Stephan, Gorrasi, José, Brandt, Sebastian, Djafarzadeh, Siamak, Brügger, Lukas, Takala, Jukka   +7 more
core   +1 more source

Prehospital Risk Stratification Using Unsupervised Machine Learning in STEMI

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
Machine learning identified three phenotypes with 30‐day mortality of 3.4%, 22.1%, and 75%. Phenotype‐2 reveals an "occult high‐risk" group: hemodynamically stable yet six‐fold higher mortality. ABSTRACT Background ST‐elevation myocardial infarction (STEMI) exhibits substantial clinical heterogeneity complicating prehospital risk stratification ...
Ana Ramos‐Rodríguez, Raúl López‐Izquierdo, Carlos del Pozo Vegas, María Plaza‐Martín, Cristina Tapia‐Ballesteros, Juan F. Delgado Benito, Ancor Sanz‐García, Francisco Martín‐Rodríguez   +7 more
wiley   +1 more source

Diagnostic value of “base deficit” in arterial blood gas analysis in comparison with hyperlactatemia as an indicator of tissue hypoperfusion in cardiac surgery

Iranian South Medical Journal, 2009
Background: Hyperlactatemia is a well known index for tissue hypoperfusion which is not routinely measured in all surgical procedures. The aim of this study was to evaluate the diagnostic value of base deficit in detecting hyperlactatemia and also ...
Rasoul Azarfarin, Iesa Bile jani, Amir abbas Kianfar, Mousa Miri nejad, Azin Alizadeh asl   +4 more
doaj  

Severe hyperlactatemia in the emergency department: clinical characteristics, etiology and mortality

BMC Emergency Medicine
Background Severe hyperlactatemia (lactate level ≥ 10 mmol/L) is associated with high mortality rates in critically ill patients. However, there is limited data on emergency department (ED) patients.
Thanat Tangpaisarn, Byron C. Drumheller, Ronnakorn Daungjunchot, Praew Kotruchin, Kiattichai Daorattanachai, Pariwat Phungoen   +5 more
doaj   +1 more source