Results 111 to 120 of about 116,541 (302)

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Runt-related transcription factor 3 promoter hypermethylation and gastric cancer risk: A meta-analysis

Open Life Sciences, 2018
The aim of this study was to investigate the correlation between runt-related transcription factor 3 (RUNX3) gene promoter hypermethylation and gastric cancer risk by meta-analysis.
Lina Mei, Changan Wu, Qing Zhao
doaj   +1 more source

Hypermethylation of MGMT and DAPK gene promoters is associated with tumorigenesis and metastasis in oral squamous cell carcinoma

Journal of Dental Sciences, 2011
Background/purpose: Oral squamous cell carcinoma (OSCC) is the fourth major cause of mortality among males in Asia. The tumorigenesis of OSCC is a multi-step process characterized by sequential morphological changes.
Yong-Kie Wong, Li-Tsu Lee, Chung-Ji Liu
doaj   +1 more source

The transformative potential of artificial intelligence in pediatric medicine: Current applications, methodological challenges, and future directions

Pediatric Investigation, EarlyView.
Artificial intelligence (AI) offers transformative potential for paediatric diagnosis and treatment, yet implementation faces unique challenges, including data scarcity, algorithmic bias, and children's developmental physiology. This review examines current applications and charts a path toward transparent, equitable, and trustworthy AI in child health.
Ruisong Wang, Xiaoman Ding, Wanyue Zhang, Tieliu Shi   +3 more
wiley   +1 more source

DNA hypermethylation patterns of APC gene promoter in Vietnamese high-risk HPV infected patients

Ho Chi Minh City Open University Journal of Science - Engineering and Technology, 2016
Cervical cancer is the leading cause of cancer death in women in Vietnam. Virtually, cervical cancers are associated with infection of HPV (Human papilloma virus).
Truong Kim Phuong, Lao Duc Thuan, Le Huyen Ai Thuy   +2 more
doaj  

Epigenetic Down-Regulation of Sirt 1 via DNA Methylation and Oxidative Stress Signaling Contributes to the Gestational Diabetes Mellitus-Induced Fetal Programming of Heart Ischemia-Sensitive Phenotype in Late Life. [PDF]

, 2019
Rationale: The incidence of gestational diabetes mellitus (GDM) is increasing worldwide. However, whether and how GDM exposure induces fetal programming of adult cardiac dysfunctional phenotype, especially the underlying epigenetic molecular mechanisms ...
Chen, Zewen, Gong, Lei, Li, Yong, Liu, Bailin, Xiao, Daliao, Zhang, Lubo, Zhang, Peng, Zhuang, Jian   +7 more
core  

Molecular and genomic advances in breast cancer: A comprehensive review of predictive and therapeutic innovations

Precision Medical Sciences, EarlyView.
Breast cancer subtypes, estrogen receptor‐positive (ER+), HER2‐enriched, and TNBC, are defined by genomic and epigenetic signatures. Multi‐omics profiling, immunotherapy, liquid biopsy, and AI‐driven radiogenomics enable precision medicine. Tools like Oncotype DX and PAM50 support personalized care.
Samina Malik, Arif Malik, Shahzad Ahmad, Hassan Mohsin, Shazia Iqbal   +4 more
wiley   +1 more source

T‐cell differentiation stage block bias confers hypermethylation and mediastinal preference in T‐cell lymphoblastic lymphoma

Clinical and Translational Medicine
Background The clinical guideline classifies T‐LBL and T‐ALL jointly, differentiating them merely by the bone marrow blast cell proportion. However, their distinct clinical manifestations, genetic profiles, and specific pathogenic requirements have ...
Jiali Wang, Bo Qian, Xiaowen Yu, Yidan Zhang, Chunlei Zhou, Tingting Yang, Le Xia, Gang Zhang, Yi‐Xuan Zhang, Yaping Wang, Yongjun Fang   +10 more
doaj   +1 more source

Epigenetic Silencing of Cellular Retinol-Binding Proteins in Nasopharyngeal Carcinoma

Neoplasia: An International Journal for Oncology Research, 2005
Aberrant retinoid signaling in human cancers is extending from the nucleus to the cytoplasm. Recently, we have demonstrated frequent epigenetic inactivation of a retinoic acid receptor (RAR), RARβ2, in nasopharyngeal carcinoma (NPC).
Joseph Kwong, Kwok-Wai Lo, Lillian Shuk-Nga Chow, Ka-Fai To, Kwong-Wai Choy, Franky Leung Chan, Samuel C. Mok, Dolly P. Huang   +7 more
doaj   +1 more source

Epigenetic Regulation of Immune Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome

The Prostate, EarlyView.
ABSTRACT Background Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent and debilitating condition with unclear etiology. Increasing evidence implicates immune dysregulation, yet the molecular mechanisms underlying impaired immune regulation remain poorly defined. This study investigated the role of altered immune responses within
Praveen Thumbikat, Goutham Pattabiraman, Farzaneh Sharifzad, Yongyong Yang, Zhiqiang Liu, Catherine V. Osborn, Stephen F. Murphy, Qi Cao, Anthony J. Schaeffer   +8 more
wiley   +1 more source