Results 131 to 140 of about 70,734 (243)

Editorial Expression of Concern: Frequent inactivation of RUNX3 by promoter hypermethylation and protein mislocalization in oral squamous cell carcinomas. [PDF]

J Cancer Res Clin Oncol
Gao F, Huang C, Lin M, Wang Z, Shen J, Zhang H, Jiang L, Chen Q.   +7 more
europepmc   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Puerarin Reverses UV-Induced Epigenetic Silencing of the Wnt/β-Catenin-KIT Axis to Mitigate Skin Fibroblast Aging. [PDF]

Int J Mol Sci
Zheng S, Hong Y, Xiao Y, Yijiati A, Mo Y, Yu X, Huang S, Xian X, Jiang Y, Wei Q, Yang X, He Z.   +11 more
europepmc   +1 more source

Gastric Mucosal Molecular Alterations and Multimodal Field‐Based Risk Models for Gastric Cancer Development

Cancer Science, EarlyView.
DNA methylation in non‐neoplastic background gastric mucosa reflects cumulative inflammatory and exposure‐related field changes before cancer develops. Combining methylation with clinical, endoscopic, histological, and emerging multimodal information may refine calibrated gastric cancer risk prediction and support risk‐adapted personalized endoscopic ...
Genki Usui, Atsushi Kaneda
wiley   +1 more source

Retraction: SPAG6 hypermethylation silences a novel tumor suppressor and inhibits renal cell carcinoma progression via PI3K/AKT/mTOR pathway. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Oncogenic BRAF and KRAS Promote Global DNA Hypomethylation Through a Directed Pathway That Upregulates TET3

Cancer Science, EarlyView.
Oncogenic BRAF and KRAS promote global DNA hypomethylation through a directed pathway that increases the levels of TET3, which helps drive tumorigenesis. ABSTRACT Aberrant epigenetic modification is one of the characteristics of the cancer genome.
Ichiro Onoyama, W. Rod Hardy, Shoichiro Takeishi, Lihua Julie Zhu, Yanglan Tan, Lloyd Hutchinson, Jianhong Ou, Leyuan Ma, Ching‐Man Virbasius, Masafumi Yasunaga, Keiichi I. Nakayama, Scott A. Shaffer, Michael R. Green   +12 more
wiley   +1 more source

Early blood DNA methylation patterns associated with glycemic progression in a prospective Indian cohort. [PDF]

Clin Epigenetics
Satheesh G, Asokan AK, Vijayakumar G, Rajavelu A, Rao SN, Sivakumar KC, Jaleel A.   +6 more
europepmc   +1 more source

Splicing Factor Mutations in Clonal Hematopoiesis and Progression to Myeloid Neoplasms

Cancer Science, EarlyView.
Splicing factor (SF)‐mutant CH is characterized by relatively late emergence and accelerated clonal expansion in older individuals. This review summarizes its clonal dynamics, disease‐associated consequences of SF mutations in myeloid neoplasms, and candidate mechanisms that may contribute to age‐dependent selection.
Yang Lyu, Yutong Zhang, Ayana Kon
wiley   +1 more source

Global Research Trends in Gastric Cancer Epigenetics From 2005 to 2025. [PDF]

Cureus
Yuan D, Li Y, Yi H, Lei Y, Zhou Y.
europepmc   +1 more source

Repression of ROBO1 Enhances Cisplatin Sensitivity in Hypermethylated Subtype of HPV‐Positive Head and Neck Carcinoma

Cancer Science, EarlyView.
DNA hypermethylation causally correlates with better treatment response of HPV(+) HNSCC, and its chemosensitivity might be enhanced by silencing of methylation target genes. Silencing of ROBO1 enhances, and its overexpression reduces, CDDP chemosensitivity, and epigenetic or ROBO1‐targeted interventions may improve therapeutic outcomes in resistant HPV(
Kenta Saeda, Takuya Nakagawa, Atsushi Okabe, Kazuko Kita, Tomoya Kurokawa, Masaki Fukuyo, Hiroki Ueda, Motoaki Seki, Bahityar Rahmutulla, Syuji Yonekura, Toyoyuki Hanazawa, Atsushi Kaneda   +11 more
wiley   +1 more source