Results 121 to 130 of about 70,734 (243)

Sporadic Hepatocellular Carcinoma in an Adolescent Harboring a Somatic CDH1 Mutation: A Case Report and Literature Review

The Kaohsiung Journal of Medical Sciences, EarlyView.
Chang‐Wei Su, Peir‐In Liang, Shih‐Chang Chuang   +2 more
wiley   +1 more source

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, EarlyView.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source

No Evidence for an Association Between DIP2B Repeat Expansion and Neurological Disease

Movement Disorders, EarlyView.
Chia‐Ying Ko, Leon Schütz, Thomas Braun, Elena Buena‐Atienza, Nicolas Casadei, Danique Beijer, Ludger Schöls, Tobias B. Haack, Stephan Ossowski, Holger Hengel   +9 more
wiley   +1 more source

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

<i>NOS1</i> hypermethylation may participate in the colorectal cancer development and be associated with its prognosis. [PDF]

Epigenetics
Zhang Z, Yeerken A, Shao X, Qian S, Lin S, Gu S, Ying X, Li Z, Fei X, Yang J, Tang M, Wang J, Jin M, Chen K.   +13 more
europepmc   +1 more source

Sperm Mitochondrial DNA Copy Number and Nuclear DNA Methylation Across Clinical and Non‐Clinical Preconception Cohorts

Andrology, EarlyView.
ABSTRACT Background Sperm mitochondrial DNA copy number is an emerging marker of male fertility, with elevated mtDNAcn associated with poor semen quality across various populations. Sperm DNA methylation has also been previously demonstrated to be negatively correlated with semen parameters in IVF cohorts.
Savni Sawant, Karolina Nowak, Amanda L. Paskavitz, Emily Houle, Ricardo P. Bertolla, Lidia Minguez‐Alarcon, Russ Hauser, J. Richard Pilsner   +7 more
wiley   +1 more source

Epigenetics as a mechanism of lineage extinction and relapse of B-cell lymphoma treated with CD19 CAR T-cell therapy. [PDF]

Blood Neoplasia
Torabi A, Love J, Wu D, Hirayama A, Naresh K.   +4 more
europepmc   +1 more source

CRYAB is compromised in pathologically affected oligodendrocytes in multiple system atrophy

Brain Pathology, EarlyView.
CRYAB is hypermethylated and colocalizes with α‐synuclein in multiple system atrophy oligodendrocytes.
Finula I. Isik, Jen‐Hsiang T. Hsiao, Felicia Xaveria Suteja, Shrey Shahdadpuri, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim, YuHong Fu   +7 more
wiley   +1 more source

A progeria syndrome links DNA hypermethylation to age-related pathology. [PDF]

Nat Genet
Sarni D, Neary G, Carroll PL, Vink CS, Billard CV, Isobe T, Weng X, Portman JR, McCartney DL, Heyn P, van 't Hof RJ, Morrison LR, Martin CA, Stok C, Harley ME, Leitch A, van den Ancker M, Robertson N, Kitto L, Clark R, Rennie M, Popravko A, McClure JJ, Parry DA, Camiolo G, Leah T, Jakobczyk H, Megaw R, McKie L, Marshall GF, Balkic N, Amiel J, Barragán Arévalo T, Bronken McCarthy G, Buchanan CA, Buffet A, Cascón A, Cogne B, Conrad S, Cueto-González AM, Currás-Freixes M, Houge GD, Fong CT, George-Abraham JK, Gibson K, Ibáñez L, Longo N, Lussey-Lepoutre C, Miller BS, Moles-Fernandez A, Pillai NR, Tvrdik T, Vincent M, Yokoyama E, Abbott CM, Sanchez-Luque FJ, Ottersbach K, De Bari C, Roelofs AJ, Tillotson R, Kranc KR, Brown SJ, Marioni RE, Crisan M, Göttgens B, Henderson NC, Semple RK, Myant KB, Dzierzak E, Reijns MAM, Sproul D, Jackson AP.   +71 more
europepmc   +1 more source

ALT phenotype assessment in IDH‐mutant astrocytoma supports biologic consequence of ATRX missense mutations

Brain Pathology, EarlyView.
A meaningful subset of IDH‐mutant astrocytoma harbors ATRX missense variants that retain ATRX IHC immunoreactivity yet exhibit functional ALT activation, supporting the biologic relevance of these missense mutations.
Oguzhan O. Kizilkaya, Kevin Y. Zhang, Mohamed Sherief, Debraj Mukherjee, Chetan Bettegowda, Matthias Holdhoff, Victoria Croog, Solmaz Sahebjam, David O. Kamson, Jordina Rincon‐Torroella, Karisa C. Schreck, Charles G. Eberhart, Alan Meeker, Calixto‐Hope G. Lucas   +13 more
wiley   +1 more source