Results 241 to 250 of about 116,541 (302)

DNA Methylation Regulates CDK5R1 and NRBP1 to Exert Effects on Alcohol Dependence: Insights From Mendelian Randomization

Addiction Biology, Volume 31, Issue 5, May 2026.
This study employed integrative Mendelian Randomization analysis to identify 10 drug‐targetable genes with altered expression in alcohol dependence. Colocalization evidence suggests shared causal variants. Crucially, DNA methylation at specific sites (cg07437263, cg05102552) mediates risk by upregulating the protective gene CDK5R1 (63.92%) and ...
Fuyuan Deng, Junsheng Peng, Siran Lai, Guangpeng Zhang, Miaomiao Li, Yuxin Huang, Mi Yuan, Gaolei Yao, Peiming Zhang, Liming Lu   +9 more
wiley   +1 more source

Epigenetic silencing of DLEC1 correlates with tumor immune microenvironment and predicts immunotherapy prognosis in multiple cancers. [PDF]

Hum Genet
Ming R, Xiong Q, Tan SY, Li L, Bao S, Wang J, Zhao L, He X, Zheng Z, Wang Y, Liu X, Tang J, Wu Z, Xiang T, Tao Q.   +14 more
europepmc   +1 more source

Chemotherapy‐driven expression of WNT ligands in bone marrow stromal cells contributes to chemoresistance in acute lymphoblastic leukaemia

British Journal of Haematology, Volume 208, Issue 5, Page 1572-1583, May 2026.
Chemotherapy‐induced WNT ligand secretion by bone marrow (BM) stroma drives acute lymphoblastic leukaemia (ALL) chemoresistance. WNT pathway inhibition disrupts this cross‐talk and restores therapeutic response, highlighting WNT inhibitors as a promising strategy to prevent relapse in ALL.
Foteini Kalampalika, Amanda Jiménez‐Pompa, Raúl Sánchez‐Lanzas, Bela Patel, Miguel Ganuza   +4 more
wiley   +1 more source

Associations Between Non-Genetic Risk Factors and DNA Methylation Alterations in Barrett's Esophagus and Its Progression to Esophageal Adenocarcinoma. [PDF]

Int J Mol Sci
Riahi Dehkordi N, Kruusmaa K, Krishnadath KK, Bertossi A.   +3 more
europepmc   +1 more source

Maternal exercise improves vascular function in hypertensive offspring via A‐kinase anchoring protein 150 gene (Akap5) epigenetic modifications

British Journal of Pharmacology, Volume 183, Issue 10, Page 2592-2612, May 2026.
Background and Purpose Regular physical activity is an effective non‐pharmacological approach to hypertension management and maternal exercise improves offspring cardiovascular health, although mechanisms remain unclear. A‐kinase anchoring protein 150 (AKAP150) targets protein kinase Cα to L‐type Ca2+ channels (CaV1.2), enhancing vascular tone in ...
Fang Qiu, Yanyan Zhang, Meiling Shan, Jiaqi Cao, Zihan Fan, Zhaoxia Xu, Xiaozhen Ding, Xiaodong Liu, Lijun Shi   +8 more
wiley   +1 more source

Construction of a DNA Methylation Map of Argali Hybrid Sheep During Mo Infection. [PDF]

Microorganisms
Zhang Q, Li S, Cheng G, Zhao G, Zhou Y, Sun Y, Zhang Y.   +6 more
europepmc   +1 more source

Systematic Multiplatform Discovery of Methylation Markers Enables Non‐Invasive Early Detection of Endometrial Cancer

Cancer Science, Volume 117, Issue 5, Page 1412-1421, May 2026.
We identified key endometrial cancer DNA methylation biomarkers (ZNF626, GRIA4, SPDYA) from cervical cells. The model achieved high endometrial cancer sensitivity and detected 92.86% of Stage I endometrial cancers using TCT samples. ABSTRACT Endometrial cancer, the most common gynecological malignancy with an annual increase of 1%–3%, lacks suitable ...
Yan Cai, Shuchao Chen, Zhen Wu, Jinxia Guan, Jie Zhao, Jianwei Ye, Baochen Du, Xiaoliang Han, Tong Shu, Guangpeng Zhou, Hong Zheng   +10 more
wiley   +1 more source

A New Complexity Layer: DNA Methylation and the Predictive Impact of Epigenetic Tests. [PDF]

Int J Mol Sci
Ladisa G, Montenegro F, Picerno A, Nigro A, Cicirelli A, Stasi A, Fiorentino M, Pontrelli P, Gesualdo L, Sallustio F.   +9 more
europepmc   +1 more source

Targeting Inflammation and Immune Regulation in Chronic Inflammation Associated Cancers

Cancer Science, Volume 117, Issue 5, Page 1209-1222, May 2026.
Chronic inflammation sustains activation of key inflammatory pathways, including Nuclear factor kappa B (NF‐κB), Interleukin‐6‐signal transducer and activator of transcription 3 (IL6‐STAT3), Phosphoinositide 3‐kinase/Akt (PI3K/Akt), and Wingless/β‐catenin (Wnt/β‐catenin) signaling. This promotes immune dysregulation through the expansion and functional
Lawan Rabiu, Mengzhu Chinn, Feng Chen, Yerkezhan Yerkinkazhina, Yuan Tian, Wei‐Guo Zhu   +5 more
wiley   +1 more source