Results 231 to 240 of about 116,541 (302)

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases. [PDF]

MedComm (2020)
Dadzadi M, Ramazi S, Darvazi M, Yoosefi S, Abbasi M, Farsad S.   +5 more
europepmc   +1 more source

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source

The Role of DNA Methyltransferases in Urinary System Diseases. [PDF]

Cancer Innov
Dong W, Pei S, Zhu D, Zeng C, Qiu Y, Wu Y, Jia X, Zhang S, Li C, Zhang W, Zhang W, Chen Z.   +11 more
europepmc   +1 more source

Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 5, May 2026.
This graphical abstract summarizes how classical and emerging histone posttranslational modifications (PTMs), together with their chromatin regulators (writers, erasers, and readers), govern major pathobiological programs in cardiovascular disease.
Yu Zheng, Yu‐Xuan Gao, Mei‐Xing Guo, Li‐Ting Wang, Xiao‐Wen Zheng, Yi‐Hao Liao, Ya Li, Jun‐Ping Zhu, Jia‐Ming Wei   +8 more
wiley   +1 more source

Instability in Pentanucleotide Markers in a Subset of Microsatellite Instability-High Colorectal Cancer. [PDF]

Curr Oncol
Yilmaz A, Frankel WL, Swanson BJ, Miller K, Bacher J, Bigley C, Nelsen L, Kalady MF, Coleman JF, Pearlman R, Hampel H.   +10 more
europepmc   +1 more source

Maternal Chrono‐Nutrition and Placental DNA Methylation: The BiSC Study

Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.
This is the first study to examine how the timing of a mother's meals during pregnancy relates to changes in placental DNA methylation, an epigenetic mark. We found that the timing of the last daily meal was most important. Some epigenetic changes were linked to genes involved in placental function and development, and the long‐term health consequences
Joana Llauradó‐Pont, Sofia Aguilar‐Lacasaña, Marta Cosin‐Tomas, Jordi Julvez, Oren Contreras‐Rodríguez, Manolis Kogevinas, Kyriaki Papantoniou, Elisa Gallo, Barbara N Harding, Martine Vrijheid, Payam Dadvand, Mariona Bustamante, Camille Lassale   +12 more
wiley   +1 more source

SFMBT2 hypermethylation promotes colorectal cancer progression and is a potential noninvasive biomarker for advanced CRC. [PDF]

iScience
Wang W, Yu L, He W, Wu J, Li Y, Cui W, Ye D, Zhou J, Xie M, Lai X, Lei C.   +10 more
europepmc   +1 more source

GatorST: A Versatile Contrastive Meta‐Learning Framework for Spatial Transcriptomic Data Analysis

Small Methods, Volume 10, Issue 9, 8 May 2026.
GatorST learns spatially informed embeddings for spatial transcriptomics by coupling two‐hop subgraph graph convolutions with cluster‐aware pseudo‐label supervision and episodic contrastive meta‐learning. The framework captures neighbor‐level topology and tissue‐wide expression semantics without heavy augmentations, delivering robust representations ...
Zhenhao Zhang, Yuxi Liu, Song Wang, Qin Ma, Qianqian Song, Jiang Bian   +5 more
wiley   +1 more source

Base-resolution DNA methylome of human MDS hematopoietic stem cell reveals TET2-GFI1 epigenetic axis repressing MDS. [PDF]

Immun Inflamm
Hu L, Shen Q, Gu Y, Lu J, Li Y, Liu N, Zhang B, Han Y, Zhang Q, Cao X.   +9 more
europepmc   +1 more source