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Methadone Induces Hypermethylation of Human DNA
Epigenomics, 2015Increased global DNA methylation in the blood of patients chronically exposed to opioids had been interpreted as an indication of an epigenetic action of this drug class.To strengthen the causality, human MCF7 cells were cultured in media with the addition of several known or potential modulators of DNA methylation including methadone.Following 3 days ...
Claudia, Knothe +3 more
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[Hypermethylation and prostate cancer].
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, 2010The diagnosis of localized prostate cancer is in constant modification. Recent studies on early diagnosis and prognosis analysis have demonstrated the limits of using PSA. The challenge for the upcoming years will be to adapt therapeutic strategies for each patient according to more reliable tests.
M, Colombel +3 more
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Hypermethylation of the p16 gene in nasopharyngeal carcinoma.
Cancer research, 1996We have recently reported that inactivation of the p16 gene by mutation and deletion is common in nasopharyngeal carcinoma (NPC). The present study demonstrates that hypermethylation of the 5' CpG island can serve as an alternative mechanism for inactivation of the p16 gene in this tumor.
Chung, YF +9 more
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