Results 221 to 230 of about 116,541 (302)

Detection of recurrent endometrial cancer via DNA methylation analysis of cervicovaginal self‐samples and urine

International Journal of Cancer, Volume 158, Issue 9, Page 2491-2500, 1 May 2026.
What's new? Post‐treatment surveillance for endometrial cancer aims to detect recurrence early, potentially improving outcome. Emerging evidence suggests that DNA methylation analysis of self‐collected cervicovaginal and urine samples is a promising approach.
Annick J. Nouwens, Mirte Schaafsma, Nienke E. van Trommel, Jenneke C. Kasius, Renske D. M. Steenbergen, Maaike C. G. Bleeker   +5 more
wiley   +1 more source

The bladder cancer m⁶A landscape is defined by global methylation dilution and focal 3'-UTR hypermethylation. [PDF]

EMBO Rep
Koch J, Xu J, Bormann F, Coutinho Carneiro V, Neuberger M, Nitschke K, Nientiedt M, Erben P, Michel MS, Rodriguez-Paredes M, Lyko F.   +10 more
europepmc   +1 more source

From DNA Methylation Microarray to Digital PCR: A Stepwise Strategy for Tissue Specific cfDNA Biomarker Development

Journal of Clinical Laboratory Analysis, Volume 40, Issue 9, May 2026.
Overview of a DNA methylation biomarker development pipeline, from discovery and assay design to screening, performance evaluation, and specificity testing in clinical sample matrices. ABSTRACT Background Tissue‐specific cell‐free DNA (cfDNA) offers promise as a minimally invasive biomarker of organ injury.
David H. Murray, Nicky Boulter, Shanon Ranjit, Natasha M. Rogers, Sarah Kummerfeld, Jason P. Ross, Rodney J. Scott   +6 more
wiley   +1 more source

Maternal Inflammation Alters Nuclear and Mitochondrial DNA Methylation Patterns in Neonatal Brain Monocytes. [PDF]

Cells
Ebenezer AT, Hicks JR, Hollander B, Hone A, Batish M, Akins R, Marsh A, Wright-Jin E.   +7 more
europepmc   +1 more source

Whole‐Genome Bisulfite Sequencing Identifies Blood‐Based DNA Methylation Biomarker for Hepatocellular Carcinoma

Molecular Carcinogenesis, Volume 65, Issue 5, Page 603-614, May 2026.
ABSTRACT Functional DNA methylation abnormalities are a hallmark of human cancers and may be a promising biomarker for their early diagnosis. Moreover, the largest methylation differences can improve the sensitivity of noninvasive diagnoses of solid tumors.
Junsheng Zhao, Sijia Shen, Junjie Zhang, Ying Xu, Jing Peng, Hainv Gao, Lanjuan Li   +6 more
wiley   +1 more source

DNA methylation at OsAmy3E promoter is involved in grain quality under heat stress in rice (Oryza sativa L.). [PDF]

Sci Rep
Chen WJ, Suriyasak C, Nong HT, Oyama Y, Kobayashi T, Matsumoto R, Kawaguchi R, Yang X, Miyahara K, Hamaoka N, Ishibashi Y.   +10 more
europepmc   +1 more source

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions. [PDF]

Mol Biomed
Yang J, Zhang M, Zhong Y, Sun C, Zhuang J.   +4 more
europepmc   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Bacterial lipopolysaccharide alters DNA methylation in colorectal cancer cells. [PDF]

Clin Epigenetics
Permain J, Sulit A, Eglinton T, Purcell R.   +3 more
europepmc   +1 more source