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Oxalate Nephropathy in a Patient With Chronic Pancreatitis and Recent Surgery: A Clinical Conundrum [PDF]
Kidney MedicineCalcium oxalate nephropathy is a rare condition with both primary and secondary causes. Primary hyperoxaluria, an inherited disorder, leads to liver oxalate overproduction, whereas secondary hyperoxaluria, or enteric hyperoxaluria, may be multifactorial ...
Robert Seby +7 more
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Hyperoxaluria by the AGXT gene: a case report [PDF]
Journal of Medical Case ReportsBackground This report details a case of AGXT gene mutation in a male patient, 9 years 6 months old, Portuguese ethnicity, with history of nephrocalcinosis and recurrent nephrolithiasis in childhood, which progressed to chronic kidney disease.
Alessandra Vitorino Naghettini +5 more
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Hydrogen Sulfide Deficiency Contributes to Tubular Damage and Calcium Oxalate Crystal Formation in Hyperoxaluria Nephropathy: Role of Osteopontin and Tamm–Horsfall Protein [PDF]
AntioxidantsHydrogen sulfide (H2S) exerts regulatory functions in kidney diseases. However, its protective role against kidney stone formation remains unclear. Here, we demonstrate that hyperoxaluria or oxalate exposure impairs H2S formation, leading to tubular ...
Chien-Lin Lu +4 more
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The domestic pig as a translational model of hyperoxaluria: a pilot study of acute and chronic sodium oxalate infusion [PDF]
Frontiers in PhysiologyThe purpose of this pilot study was to develop and characterize an in vivo porcine model of hyperoxaluria using intravenous infusion of sodium oxalate (NaOx). Two experimental regimens were developed to replicate acute and follow up chronic hyperoxaluria.
Tomasz Jacek +17 more
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Scientific Reports, 2023 The risk of enteric hyperoxaluria is significantly increased after malabsorptive bariatric surgery (MBS). However, its underlying determinants are only poorly characterized. In this case–control study, we aimed at identifying clinical and genetic factors
Lotte Scherer +8 more
doaj +1 more source
Frontiers in Pediatrics, 2023 ObjectivesThe survival of pediatric patients with short bowel syndrome has improved in recent years. Enteric hyperoxaluria as a pathophysiological consequence has been hardly addressed so far.
Jan Thomas Schaefer +10 more
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Lanthanum carbonate to control plasma and urinary oxalate level in type 1 primary hyperoxaluria?
IJU Case Reports, 2021 Introduction The therapy to reduce urinary oxalate excretion in primary hyperoxaluria type 1 is still required. Case presentation A 37‐year‐old hemodialyzed man suffered from systemic oxalosis secondary to primary hyperoxaluria type 1 exhibited a drastic
Agnieszka Pozdzik +4 more
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Frontiers in Molecular Biosciences, 2022 Pediatric nephrolithiasis (NL) or Kidney stone disease (KSD) is an untethered topic in Asian population. In Western countries, the annual incidence of paediatric NL is around 6–10%.
Arindam Chatterjee +14 more
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Primary Hyperoxaluria Type 1: The First Patient Treated with Lumasiran in Portugal
Revista Portuguesa de Nefrologia e Hipertensão, 2023 Primary hyperoxaluria type 1 is a rare genetic disease caused by mutations in AGXT, leading to an excessive hepatic production of oxalate, resulting in urolithiasis, nephrocalcinosis and chronic kidney disease.
Madalena Almeida Borges +5 more
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Postbiotics and Kidney Disease
Toxins, 2022 Chronic kidney disease (CKD) is projected to become the fifth global cause of death by 2040 as a result of key shortcomings in the current methods available to diagnose and treat kidney diseases.
Chiara Favero +5 more
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