Results 1 to 10 of about 87,376 (182)
A Controlled System for Parahydrogen Hyperpolarization Experiments [PDF]
MoleculesParahydrogen-induced hyperpolarization (PHIP), introduced nearly four decades ago, provides an elegant solution to one of the fundamental limitations of nuclear magnetic resonance (NMR)—its notoriously low sensitivity.
Lorenzo Franco +6 more
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Microbiology Spectrum, 2023 Shigellosis caused by Shigella is one of the most important foodborne illnesses in global health, but little is known about the metabolic cross talk between this bacterial pathogen and its host cells during the different stages of the infection process ...
Ke-Chuan Wang +3 more
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Hyperpolarized 13C NMR for longitudinal in-cell metabolism using a mobile 3D cell culture system
Journal of Magnetic Resonance Open, 2023 Hyperpolarization with the dissolution dynamic nuclear polarization (dDNP) technique yields > 10,000-fold signal increases for NMR-active nuclei (e.g. 13C).
T.B.W. Mathiassen +7 more
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Hyperpolarized Carbon-13 MRI in Breast Cancer
Diagnostics, 2023 One of the hallmarks of cancer is metabolic reprogramming, including high levels of aerobic glycolysis (the Warburg effect). Pyruvate is a product of glucose metabolism, and 13C-MR imaging of the metabolism of hyperpolarized (HP) [1-13C]pyruvate (HP 13C ...
Ramona Woitek, Kevin M. Brindle
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Toxins, 2021 The voltage-gated sodium channel Nav1.8 is linked to neuropathic and inflammatory pain, highlighting the potential to serve as a drug target. However, the biophysical mechanisms that regulate Nav1.8 activation and inactivation gating are not completely ...
Tarek Mohamed Abd El-Aziz +11 more
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Transportable hyperpolarized metabolites [PDF]
Nature Communications, 2017 Abstract Nuclear spin hyperpolarization of 13 C-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by ...
Ji, Xiao +8 more
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Hyperpolarized para-Ethanol [PDF]
The Journal of Physical Chemistry B, 2015 We show that an imbalance between the populations of singlet (S) and triplet (T) states in pairs of magnetically equivalent spins can be generated by dissolution dynamic nudear polarization: In partly deuterated ethanol ((CD3CH2OD)-C-13), this T/S imbalance can be transferred by cross-relaxation to observable, enhanced signals of protons and coupled C ...
Mammoli, Daniele +6 more
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Electrical Pacing of Cardiac Tissue Including Potassium Inward Rectification. [PDF]
PLoS ONE, 2015 In this study cardiac tissue is stimulated electrically through a small unipolar electrode. Numerical simulations predict that around an electrode are adjacent regions of depolarization and hyperpolarization.
Suran Galappaththige, Bradley J Roth
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Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy
Metabolites, 2021 The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform on the status of both hepatic and ...
John G. Jones
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Metabolites, 2022 The liver plays an important role in whole-body glucose homeostasis by taking up glucose from and releasing glucose into the blood circulation. In the postprandial state, excess glucose in the blood circulation is stored in hepatocytes as glycogen.
Ayhan Gursan, Jeanine J. Prompers
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