Results 21 to 30 of about 129,353 (325)
Hyperpolarized NMR metabolomics
Current Opinion in Chemical Biology, 2023 Hyperpolarized NMR is a promising approach to address the sensitivity limits of conventional NMR metabolomics approaches, which currently fails to detect minute metabolite concentrations in biological samples. This review describes how tremendous signal enhancement offered by dissolution-dynamic nuclear polarization and parahydrogen-based techniques ...
Ribay, Victor +4 more
openaire +3 more sources
Electromechanical Coupling in the Hyperpolarization-Activated K+ Channel KAT1
Nature, 2020 Voltage-gated potassium (Kv) channels coordinate electrical signalling and control cell volume by gating in response to membrane depolarization or hyperpolarization. However, although voltage-sensing domains transduce transmembrane electric field changes
M. Clark +3 more
semanticscholar +1 more source
Micro-Slab Coil Design for Hyperpolarized Metabolic Flux Analysis in Multiple Samples
Bioengineering, 2022 Abnormal metabolism is a hallmark of cancer cells. Accumulating evidence suggests that metabolic changes are likely to occur before other cellular responses in cancer cells upon drug treatment.
Geonhui Lee +7 more
doaj +1 more source
Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Magnetic resonance imaging is hindered by inherently low sensitivity, which limits the method for the most part to observing water molecules in the body. Hyperpolarized molecules exhibit strongly enhanced MRI signals which opens the door for
S. Knecht +16 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2022 When mammalian spermatozoa are released in the female reproductive tract, they are incapable of fertilizing the oocyte. They need a prolonged exposure to the alkaline medium of the female genital tract before their flagellum gets hyperactivated and the ...
Bertrand de Prelle +2 more
doaj +1 more source
Hyperpolarized MR Imaging: Neurologic Applications of Hyperpolarized Metabolism [PDF]
American Journal of Neuroradiology, 2009 Hyperpolarization is the general term for a method of enhancing the spin-polarization difference of populations of nuclei in a magnetic field. No less than 5 distinct techniques (dynamic nuclear polarization [DNP]; parahydrogen-induced polarization-parahydrogen and synthesis allow dramatically enhanced nuclear alignment [PHIP-PASADENA]; xenon/helium ...
B D, Ross +4 more
openaire +2 more sources
Gating mechanism of hyperpolarization-activated HCN pacemaker channels
Nature Communications, 2020 Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain, and mutations in HCN channels are linked to heart arrhythmia and epilepsy. HCN channels belong to the family of voltage-gated K+
Rosamary Ramentol +2 more
semanticscholar +1 more source
Effects of cromakalim (BRL 34915) on potassium conductances in CA3 neurons of the guinea-pig hippocampus in vitro [PDF]
, 1989 The action of the potassium channel activator, cromakalim (BRL 34915), on membrane potential, input resistance and current-voltage-relationship of CA3 neurons in a slice preparation of the guinea-pig hippocampus was investigated by means of intracellular
Alzheimer, Christian +2 more
core +1 more source
Hyperpolarized Nanodiamond Surfaces [PDF]
Journal of the American Chemical Society, 2016 The widespread use of nanodiamond as a biomedical platform for drug-delivery, imaging, and sub-cellular tracking applications stems from their non-toxicity and unique quantum mechanical properties. Here, we extend this functionality to the domain of magnetic resonance, by demonstrating that the intrinsic electron spins on the nanodiamond surface can be
Ewa Rej +3 more
openaire +3 more sources
Mapping of Absolute Host Concentration and Exchange Kinetics of Xenon Hyper-CEST MRI Agents
Pharmaceuticals, 2021 Xenon magnetic resonance imaging (MRI) provides excellent sensitivity through the combination of spin hyperpolarization and chemical exchange saturation transfer (CEST).
Martin Kunth +2 more
doaj +1 more source