Results 41 to 50 of about 129,353 (325)

Essential role of CFTR in PKA-dependent phosphorylation, alkalinization, and hyperpolarization during human dperm capacitation [PDF]

, 2017
Mammalian sperm require to spend a limited period of time in the female reproductive tract to become competent to fertilize in a process called capacitation.
Austin, Berger, Bobadilla, Buffone, Buffone, Buffone, Buffone, Chang, Chen, Chen, Chen, Chávez, Chávez, De Jonge, De La Vega-Beltran, Demarco, Diao, Dirami, Dostmann, Ellsworth, Escoffier, Esteves, Figueiras-Fierro, Gabriel, Gadsby, Hernández-González, Ishiguro, José, Kase, Kujala, Köhn, l'Hoste, Laemmli, Leclerc, Li, Lishko, Lochner, Luconi, López-González, Ma, Melis, Mortimer, Muanprasat, Navarrete, Neill, Nishigaki, Nolan, Okamura, Rode, Schulz, Sheppard, Sorum, Stival, Stival, Tabcharani, Tang, Towbin, Visconti, Visconti, Wennemuth, Wertheimer, Xu, Zeng, Zeng   +63 more
core   +1 more source

Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-¹³C]ketoisocaproate

Metabolites, 2023
Efficient 13C hyperpolarization of ketoisocaproate is demonstrated in natural isotopic abundance and [1-13C]enriched forms via SABRE-SHEATH (Signal Amplification By Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei).
Isaiah Adelabu, Md Raduanul H. Chowdhury, Shiraz Nantogma, Clementinah Oladun, Firoz Ahmed, Lukas Stilgenbauer, Marianna Sadagurski, Thomas Theis, Boyd M. Goodson, Eduard Y. Chekmenev   +9 more
doaj   +1 more source

Hyperpolarized NMR Probes for Biological Assays

Sensors, 2014
During the last decade, the development of nuclear spin polarization enhanced (hyperpolarized) molecular probes has opened up new opportunities for studying the inner workings of living cells in real time.
Sebastian Meier, Pernille R. Jensen, Magnus Karlsson, Mathilde H. Lerche   +3 more
doaj   +1 more source

In-vitro NMR Studies of Prostate Tumor Cell Metabolism by Means of Hyperpolarized [1-13C]Pyruvate Obtained Using the PHIP-SAH Method

Frontiers in Oncology, 2020
Nuclear Magnetic Resonance allows the non-invasive detection and quantitation of metabolites to be carried out in cells and tissues. This means that that metabolic changes can be revealed without the need for sample processing and the destruction of the ...
Eleonora Cavallari, Carla Carrera, Ginevra Di Matteo, Oksana Bondar, Silvio Aime, Francesca Reineri   +5 more
doaj   +1 more source

The HCN Channel Voltage Sensor Undergoes A Large Downward Motion During Hyperpolarization

Nature Structural & Molecular Biology, 2019
Voltage-gated ion channels (VGICs) contain positively charged residues within the S4 helix of the voltage-sensing domain (VSD) that are displaced in response to changes in transmembrane voltage, promoting conformational changes that open the pore ...
Gucan Dai, Teresa K. Aman, F. DiMaio, W. N. Zagotta   +3 more
semanticscholar   +1 more source

Hyperpolarized Dihydroxyacetone Is a Sensitive Probe of Hepatic Gluconeogenic State

Metabolites, 2021
Type II diabetes and pre-diabetes are widely prevalent among adults. Elevated serum glucose levels are commonly treated by targeting hepatic gluconeogenesis for downregulation. However, direct measurement of hepatic gluconeogenic capacity is accomplished
Mukundan Ragavan, Marc A. McLeod, Anthony G. Giacalone, Matthew E. Merritt   +3 more
doaj   +1 more source

Room temperature "optical nanodiamond hyperpolarizer": Physics, design, and operation. [PDF]

, 2020
Dynamic Nuclear Polarization (DNP) is a powerful suite of techniques that deliver multifold signal enhancements in nuclear magnetic resonance (NMR) and MRI.
Aguilar, A, Ajoy, A, Druga, E, Gierth, M, Han, B, Liu, K, Meriles, CA, Nazaryan, R, Oon, JT, Pines, A, Reimer, JA, Safvati, B, Suter, D, Tsang, R, Walton, JH   +14 more
core  

Central pattern generator for swimming in Melibe [PDF]

, 2005
The nudibranch mollusc Melibe leonina swims by bending from side to side. We have identified a network of neurons that appears to constitute the central pattern generator (CPG) for this locomotor behavior, one of only a few such networks to be described ...
Thompson, Stuart, Watson, Winsor H., III
core   +3 more sources

Quantum rotor induced hyperpolarization [PDF]

Proceedings of the National Academy of Sciences, 2010
Despite its broad applicability NMR has always been limited by its inherently low sensitivity. Hyperpolarization methods have the potential to overcome this limitation and, in the case of ex situ dynamic nuclear polarization (DNP), large enhancement factors have been achieved.
Christian, Ludwig, Martin, Saunders, Ildefonso, Marin-Montesinos, Ulrich L, Günther   +3 more
openaire   +2 more sources

Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex.

Cell, 2018
During corticogenesis, ventricular zone progenitors sequentially generate distinct subtypes of neurons, accounting for the diversity of neocortical cells and the circuits they form.
Ilaria Vitali, Sabine Fièvre, Ludovic Telley, Polina Oberst, Sebastiano Bariselli, Laura Frangeul, Natalia Baumann, J. McMahon, Esther Klingler, Riccardo Bocchi, J. Kiss, C. Bellone, Debra L. Silver, D. Jabaudon   +13 more
semanticscholar   +1 more source