Results 81 to 90 of about 129,353 (325)

In-vivo magnetic resonance imaging of hyperpolarized silicon particles

open access: yes, 2013
Silicon-based micro and nanoparticles have gained popularity in a wide range of biomedical applications due to their biocompatibility and biodegradability in-vivo, as well as a flexible surface chemistry, which allows drug loading, functionalization and ...
Bhattacharya, P. K.   +4 more
core   +1 more source

Hyperpolarized 131Xe NMR spectroscopy

open access: yesJournal of Magnetic Resonance, 2011
Hyperpolarized (hp) (131)Xe with up to 2.2% spin polarization (i.e., 5000-fold signal enhancement at 9.4 T) was obtained after separation from the rubidium vapor of the spin-exchange optical pumping (SEOP) process. The SEOP was applied for several minutes in a stopped-flow mode, and the fast, quadrupolar-driven T(1) relaxation of this spin I = 3/2 ...
Stupic, Karl F.   +3 more
openaire   +2 more sources

Room-temperature in situ nuclear spin hyperpolarization from optically pumped nitrogen vacancy centres in diamond [PDF]

open access: yesNature Communications, 2015
Low detection sensitivity stemming from the weak polarization of nuclear spins is a primary limitation of magnetic resonance spectroscopy and imaging.
J. King   +7 more
semanticscholar   +1 more source

Organelle Localization‐Induced Bio‐Orthogonal Polymerization (OLIBOP) for Photostable Super‐Resolution Live‐Cell Imaging

open access: yesAdvanced Healthcare Materials, EarlyView.
Organelle localization‐induced biorthogonal polymerization enables direct synthesis of photostable poly‐AIEgens within targeted organelles for super‐resolution live‐cell imaging. ABSTRACT Real‐time monitoring of dynamic biological processes demands fluorescent probes that can withstand prolonged light exposure without photobleaching—a critical ...
Gaeun Park   +4 more
wiley   +1 more source

Moringa oleifera leaf extract induces vasorelaxation via endothelium-dependent hyperpolarization and calcium channel blockade in mesenteric arterial beds isolated from L-NAME hypertensive rats

open access: yesClinical and Experimental Hypertension, 2020
Background An aqueous extract of Moringa oleifera leaves (MOE) is known to cause relaxation of mesenteric resistance arteries of rats in which hypertension has been induced by the administration of L-NAME, but the mechanism(s) of action of MOE remains ...
Direk Aekthammarat   +2 more
doaj   +1 more source

Detecting de novo Hepatic Ketogenesis Using Hyperpolarized [2-13C] Pyruvate

open access: yesFrontiers in Physiology, 2022
The role of ketones in metabolic health has progressed over the past two decades, moving from what was perceived as a simple byproduct of fatty acid oxidation to a central player in a multiplicity of disease states. Previous work with hyperpolarized (HP)
Mukundan Ragavan   +3 more
doaj   +1 more source

MIND-BODY RESPONSE AND NEUROPHYSIOLOGICAL CHANGES DURING STRESS AND MEDITATION: CENTRAL ROLE OF HOMEOSTASIS [PDF]

open access: yes, 2014
Stress profoundly impacts quality of life and may lead to various diseases and conditions. Understanding the underlying physiological and neurological processes that take place during stress and meditation techniques may be critical for effectively ...
Barnes, Vernon A.   +2 more
core  

11,12-EET stimulates the association of BK channel α and β(1) subunits in mitochondria to induce pulmonary vasoconstriction [PDF]

open access: yes, 2012
In the systemic circulation, 11,12-epoxyeicosatrienoic acid (11,12-EET) elicits nitric oxide (NO)- and prostacyclin-independent vascular relaxation, partially through the activation of large conductance Ca2+-activated potassium (BK) channels. However, in
Daiber, Andreas   +6 more
core   +3 more sources

Liquid-state carbon-13 hyperpolarization generated in an MRI system for fast imaging

open access: yesNature Communications, 2017
Hyperpolarized (HP) tracers dramatically increase the sensitivity of magnetic resonance imaging (MRI) to monitor metabolism non-invasively and in vivo. Their production, however, requires an extra polarizing device (polarizer) whose complexity, operation
A. Schmidt   +12 more
semanticscholar   +1 more source

Purpose‐Adaptable Reinforced 3D Hyaluronic‐Acid Based Platform to Study Pathomechanisms of the Central Nervous System

open access: yesAdvanced Healthcare Materials, EarlyView.
Platform system to create biofabricated 3D spinal cord tissue models: Combining high resolution PCL fiber placement, a customized, hyaluronic acid‐based hydrogel, two cell types (spinal cord neurons and astrocytes) together with three distinct laminin isoforms allow the formation of functional cell–cell network interactions.
Nicoletta Murenu   +12 more
wiley   +1 more source

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