Results 61 to 70 of about 2,500,398 (351)

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

European Respiratory Journal, 2019
Clinical and translational research has played a major role in advancing our understanding of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms of PH with severe vascular remodelling (e.g.
M. Humbert, C. Guignabert, S. Bonnet, P. Dorfmüller, J. Klinger, M. Nicolls, A. Olschewski, S. Pullamsetti, R. Schermuly, K. Stenmark, M. Rabinovitch   +10 more
semanticscholar   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Long-term oxygen therapy in precapillary pulmonary hypertension – SOPHA study

Scientific Reports
Current guidelines recommend oxygen (O2) supplementation in patients with pulmonary hypertension (PH), despite scarce data on long-term O2 therapy (LTOT).
Nicola Benjamin, Ishan Echampati, Satenik Harutyunova, Christina Alessandra Eichstaedt, Benjamin Egenlauf, Silvia Ulrich, Ekkehard Grünig, Panagiota Xanthouli   +7 more
doaj   +1 more source

Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology

International Journal of Cardiology Congenital Heart Disease, 2022
Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the ...
Chinthaka B. Samaranayake, Ruth McNiven, Aleksander Kempny, Carl Harries, Laura C. Price, Michael Gatzoulis, Konstantinos Dimopoulos, Stephen J. Wort, Colm McCabe   +8 more
doaj   +1 more source

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. [PDF]

, 2018
Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension ...
Ayon, Ramon J, Balistrieri, Angela, Black, Stephen M, Chen, Jiwang, Desai, Ankit A, Garcia, Joe GN, Gu, Yali, Makino, Ayako, Rischard, Franz, Song, Shanshan, Tang, Haiyang, Vanderpool, Rebecca, Vinjamuri, Sujana, Wang, Jian, Wang, Ziyi, Wu, Kang, Yuan, Jason X-J, Zhang, Qian, Zhou, Guofei   +18 more
core   +1 more source

Echocardiographic assessment of pulmonary hypertension: a guideline protocol from the British Society of Echocardiography. [PDF]

, 2018
Pulmonary hypertension is defined as a mean arterial pressure of ≥25 mmHg as confirmed on right heart catheterisation. Traditionally, the pulmonary arterial systolic pressure has been estimated on echo by utilising the simplified Bernoulli equation from ...
Augustine, DX, Bhattacharyya, S, British Society of Echocardiography Education Committee,, Coates-Bradshaw, LD, Coghlan, G, Fox, K, Grapsa, J, Harkness, A, Howard, LS, Kaye, N, Mathew, T, Nihoyannopoulos, P, Oxborough, D, Rana, BS, Ring, L, Robinson, S, Sandoval, J, Sharma, V, Siva, A, Steeds, RP, Willis, J   +20 more
core   +3 more sources

Pulmonary hypertension in bronchopulmonary dysplasia

Pediatric Research, 2020
Bronchopulmonary dysplasia (BPD) is a major complication in prematurely born infants. Pulmonary hypertension (PH) associated with BPD (BPD-PH) is characterized by alveolar diffusion impairment, abnormal vascular remodeling, and rarefication of pulmonary ...
G. Hansmann, H. Sallmon, C. Roehr, S. Kourembanas, E. Austin, M. Koestenberger   +5 more
semanticscholar   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio for the Assessment of Right Ventricular-Arterial Coupling in Severe Pulmonary Hypertension.

Circulation Cardiovascular Imaging, 2019
BACKGROUND The ratios of tricuspid annular plane systolic excursion (TAPSE)/echocardiographically measured systolic pulmonary artery pressure (PASP), fractional area change/invasively measured mean pulmonary artery pressure, right ventricular (RV) area ...
K. Tello, J. Wan, Antonia Dalmer, R. Vanderpool, H. Ghofrani, R. Naeije, F. Roller, Emad Mohajerani, W. Seeger, U. Herberg, N. Sommer, H. Gall, M. Richter   +12 more
semanticscholar   +1 more source

Perivascular Inflammation in Pulmonary Arterial Hypertension

Cells, 2020
Perivascular inflammation is a prominent pathologic feature in most animal models of pulmonary hypertension (PH) as well as in pulmonary arterial hypertension (PAH) patients.
Yijie Hu, L. Chi, W. Kuebler, N. Goldenberg   +3 more
semanticscholar   +1 more source