Process of Hypertrophic Scar Formation: Expression of Eukaryotic Initiation Factor 6
Chinese Medical Journal, 2015 Background: Hypertrophic scar is one of the most common complications and often causes the disfigurement or deformity in burn or trauma patients. Therapeutic methods on hypertrophic scar treatment have limitations due to the poor understanding of ...
Qing-Qing Yang +5 more
doaj +2 more sources
MicroRNA-21 regulates hTERT via PTEN in hypertrophic scar fibroblasts. [PDF]
PLoS ONE, 2014 As an important oncogenic miRNA, microRNA-21 (miR-21) is associated with various malignant diseases. However, the precise biological function of miR-21 and its molecular mechanism in hypertrophic scar fibroblast cells has not been fully elucidated ...
Hua-Yu Zhu +13 more
doaj +2 more sources
Acta Biochimica et Biophysica Sinica, 2022 Hypertrophic scar is a problem for numerous patients, especially after burns, and is characterized by increased fibroblast proliferation and collagen deposition.
Ma Fang +10 more
doaj +2 more sources
Investigating the role of P311 in the hypertrophic scar. [PDF]
PLoS ONE, 2010 The mechanisms of hypertrophic scar formation are not fully understood. We previously screened the differentially expressed genes of human hypertrophic scar tissue and identified P311 gene as upregulated.
Jianglin Tan +9 more
doaj +3 more sources
MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar. [PDF]
PLoS ONE, 2015 Hypertrophic scarring is a frequent fibroproliferative complication following deep dermal burns leading to impaired function and lifelong disfigurement. Decorin reduces fibrosis and induces regeneration in many tissues, and is significantly downregulated
Peter Kwan, Jie Ding, Edward E Tredget
doaj +2 more sources
Portable ultraviolet light A1 light source to treat hypertrophic scar
Dermatologica Sinica, 2015 Background/Objectives: Recently, fibrotic diseases such as hypertrophic scar, keloid, and scleroderma have been treated with UV-A1 radiation with encouraging results. However, conventional UV light sources are bulky and expensive. In this study, we aimed
Yen-Chen Huang +3 more
doaj +2 more sources
Wound natural healing in treatment of tumor-like hypertrophic scar [PDF]
Anais Brasileiros de Dermatologia, 2017 : Background: Surgical sutures, wound tension, additional skin incisions and other factors may result in recurrence of tumor-like scar. Objective: To investigate the role of wound natural healing therapy in tumor-like hypertrophic scar.
Tong Han, De-Feng Lin, Hua Jiang
doaj +3 more sources
Mediators of Inflammation, 2022 Hypertrophic scar causes serious functional and cosmetic problem, but no treatment method is known to achieve a satisfactory therapeutic effect. However, mesenchymal stem cells show a possible cure prospect.
Fang Xie +7 more
doaj +2 more sources
Targeted-Penetrating Biomimetic Hybrid Transfersomes for Enhanced Transdermal Gene Transfection in Hypertrophic Scar Therapy. [PDF]
Adv Sci (Weinh)Hypertrophic scar fibroblasts membrane‐hybridized cationic transfersomes enable efficient loading and transdermal delivery of TGF‐β1 siRNA through multiple skin penetration pathways. The biomimetic platform enhances homotypic targeting, transfection, and immune evasion, suppresses TGF‐β1‐driven fibrotic signaling, and reduces extracellular matrix ...
Xing H +9 more
europepmc +2 more sources
MODIFIED BUTTERFLY ANTI-TENSION TAPE AS A PREVENTION OF HYPERTROPHIC SCAR IN FACIAL REGION MEASURED BY JAPANESE SCAR SCALE (JSS) [PDF]
, 2022 Introduction: Abnormal scar remains an unsolved problem in some countries marked by an increase of prevalence of abnormal scar in the last 2 to 3 decades.
Tahalele, Paul L +5 more
core +1 more source