Results 1 to 10 of about 26,902 (99)

The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications

Frontiers in Immunology, 2023
Changes in lifestyle induce an increase in patients with hyperuricemia (HUA), leading to gout, gouty arthritis, renal damage, and cardiovascular injury.
Delun Li, Siyu Yuan, Yiyao Deng, Xiaowan Wang, Shouhai Wu, Xuesheng Chen, Yimeng Li, Jianting Ouyang, Danyao Lin, Haohao Quan, Xinwen Fu, Chuang Li, Wei Mao   +12 more
semanticscholar   +1 more source

Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease

International Journal of Molecular Sciences, 2021
Uric acid (UA) is synthesized mainly in the liver, intestines, and vascular endothelium as the end product of an exogenous purine from food and endogenously from damaged, dying, and dead cells.
H. Yanai, H. Adachi, M. Hakoshima, H. Katsuyama   +3 more
semanticscholar   +1 more source

Exploring the mechanism underlying hyperuricemia using comprehensive research on multi-omics

Scientific Reports, 2023
Hyperuricemia involves multiple complex metabolisms, but no study has conducted a comprehensive analysis using human blood and urine metabolomics for hyperuricemia. Serum and urine samples from 10 patients with hyperuricemia and 5 controls were collected
Hengrui Liu, Ruolin Xie, Qiongqiong Dai, Ji Fang, Yunbo Xu, Bo Li   +5 more
semanticscholar   +1 more source

Hyperuricemia and gout increased the risk of long-term mortality in patients with heart failure: insights from the National Health and Nutrition Examination Survey

Journal of Translational Medicine, 2023
Background The prevalence of hyperuricemia, gout, and heart failure (HF) is on the rise, and these conditions often share similar risk factors. The present study aimed to evaluate the relationship among hyperuricemia, gout, HF, and all-cause mortality ...
Yingdong Han, Yu Cao, Xinxin Han, H. Di, Y. Yin, Juan Wu, Yun Zhang, Xuejun Zeng   +7 more
semanticscholar   +1 more source

The Association of Surrogates of Insulin Resistance with Hyperuricemia among Middle-Aged and Older Individuals: A Population-Based Nationwide Cohort Study

Nutrients, 2023
The triglyceride–glucose (TyG) index, triglyceride-to-high-density-lipoprotein-cholesterol (TG/HDL-C) ratio, metabolic score for insulin resistance (METS-IR) and TyG with body mass index (TyG-BMI) have been proposed as indicators of insulin resistance ...
Yutong Han, Zonglei Zhou, Yuge Zhang, Genming Zhao, Biao Xu   +4 more
semanticscholar   +1 more source

Association of impaired sensitivity to thyroid hormones with hyperuricemia through obesity in the euthyroid population

Journal of Translational Medicine, 2023
Quetions To what extent is impaired sensitivity to thyroid hormones associated with hyperuricemia through body mass index (BMI) in the euthyroid population?
Zhiyuan Wu, Yue Jiang, Pingan Li, Yutao Wang, Haiping Zhang, Zhiwei Li, Xia Li, Lixin Tao, B. Gao, Xiuhua Guo   +9 more
semanticscholar   +1 more source

Research progress on the prevention and treatment of hyperuricemia by medicinal and edible plants and its bioactive components

Frontiers in Nutrition, 2023
Hyperuricemia is another common metabolic disease, which is considered to be closely related to the development of many chronic diseases, in addition to the “three highs.” Currently, although drugs show positive therapeutic effects, they have been shown ...
Cheng-yuan Wang, Jian-gang Dai
semanticscholar   +1 more source

Association between weight-adjusted-waist index and the risk of hyperuricemia in adults: a population-based investigation

Frontiers in Endocrinology, 2023
Objective This investigation sought to elucidate the potential correlation between a recently characterized adiposity metric, termed the Weight-Adjusted-Waist Index (WWI) and hyperuricemia.
Yunyi Ding, Zhuohan Xu, Xue Zhou, Yichen Luo, Ruijie Xie, Yayu Li   +5 more
semanticscholar   +1 more source

Association between hyperuricemia and chronic kidney disease: a cross-sectional study in Bangladeshi adults

BMC Endocrine Disorders, 2023
Background and aims Chronic kidney disease (CKD) is a public health concern worldwide and has been recognized as a significant risk factor for cardiovascular disease.
Z. Barman, Mahmudul Hasan, Rakib Miah, Ananya Dutta Mou, Jaasia Momtahena Hafsa, Aporajita Das Trisha, Firoz Mahmud, Nurshad Ali   +7 more
semanticscholar   +1 more source

Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout

Frontiers in Cellular and Infection Microbiology, 2022
The incidence of hyperuricemia (HUA) and gout continuously increases and has become a major public health problem. The gut microbiota, which colonizes the human intestine, has a mutually beneficial and symbiotic relationship with the host and plays a ...
Zhilei Wang, Yuchen Li, Wenhao Liao, Ju Huang, Yanping Liu, Zhiyong Li, Jianyuan Tang   +6 more
semanticscholar   +1 more source