Results 1 to 10 of about 75,055 (252)

Exploring the mechanism underlying hyperuricemia using comprehensive research on multi-omics [PDF]

Scientific Reports, 2023
Hyperuricemia involves multiple complex metabolisms, but no study has conducted a comprehensive analysis using human blood and urine metabolomics for hyperuricemia. Serum and urine samples from 10 patients with hyperuricemia and 5 controls were collected
Hengrui Liu, Ruolin Xie, Qiongqiong Dai, Ji Fang, Yunbo Xu, Bo Li   +5 more
doaj   +3 more sources

Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease

International Journal of Molecular Sciences, 2021
Uric acid (UA) is synthesized mainly in the liver, intestines, and vascular endothelium as the end product of an exogenous purine from food and endogenously from damaged, dying, and dead cells.
H. Yanai, H. Adachi, M. Hakoshima, H. Katsuyama   +3 more
exaly   +2 more sources

Hyperuricemia and gout increased the risk of long-term mortality in patients with heart failure: insights from the National Health and Nutrition Examination Survey

Journal of Translational Medicine, 2023
Background The prevalence of hyperuricemia, gout, and heart failure (HF) is on the rise, and these conditions often share similar risk factors. The present study aimed to evaluate the relationship among hyperuricemia, gout, HF, and all-cause mortality ...
Yingdong Han, Yu Cao, Xinxin Han, Hong Di, Yue Yin, Juan Wu, Yun Zhang, Xuejun Zeng   +7 more
doaj   +2 more sources

Contemporary Prevalence of Gout and Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey, 2007–2016

Arthritis and Rheumatology, 2019
To estimate the current prevalence rates and decadal trends of gout and hyperuricemia in the US, as well as the prevalence of urate‐lowering therapy (ULT) among gout patients, using 2007–2016 data from a nationally representative survey of American men ...
Chio Yokose, Michael H Pillinger, Hyon K Choi   +2 more
exaly   +2 more sources

Hyperuricemia and its related diseases: mechanisms and advances in therapy

Signal Transduction and Targeted Therapy
Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic syndrome, and diabetes, etc.
, Junjie Gao
exaly   +2 more sources

Hyperuricemia predicts increased cardiovascular events in patients with chronic coronary syndrome after percutaneous coronary intervention: A nationwide cohort study from Japan

Frontiers in Cardiovascular Medicine, 2023
BackgroundThe causal relationship between hyperuricemia and cardiovascular diseases is still unknown. We hypothesized that hyperuricemic patients after percutaneous coronary intervention (PCI) had a higher risk of major adverse cardiovascular events ...
Naoyuki Akashi, Masanari Kuwabara, Tetsuya Matoba, Takahide Kohro, Yusuke Oba, Tomoyuki Kabutoya, Yasushi Imai, Kazuomi Kario, Arihiro Kiyosue, Yoshiko Mizuno, Kotaro Nochioka, Masaharu Nakayama, Takamasa Iwai, Yoko Nakao, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Masanobu Ishii, Taishi Nakamura, Kenichi Tsujita, Hisahiko Sato, Hideo Fujita, Ryozo Nagai   +21 more
doaj   +2 more sources

Exploration of the anti-hyperuricemia effect of TongFengTangSan (TFTS) by UPLC-Q-TOF/MS-based non-targeted metabonomics

Chinese Medicine, 2023
Background TongFengTangSan (TFTS) is a commonly used Tibetan prescription for gout treatment. Previously, TFTS (CF) was confirmed to have a significant uric acid-lowering effect.
Zhichao Huang, Wugang Zhang, Qiong An, Yifan Lang, Ye Liu, Huifang Fan, Haifang Chen   +6 more
doaj   +2 more sources

Expression Profile and Potential Function of Circular RNAs in Peripheral Blood Mononuclear Cells in Male Patients With Primary Gout

Frontiers in Genetics, 2021
Circular RNAs (circRNAs) are non-coding RNAs (ncRNAs) with a single-stranded covalently closed-loop structure, and their abnormal expression may participate in the pathogenesis of various human diseases.
Fei Dai, Fei Dai, Quan-Bo Zhang, Quan-Bo Zhang, Yi-Ping Tang, Yi-Ping Tang, Yi-Xi He, Yi-Xi He, Ting Yi, Ting Yi, Yu-Feng Qing, Yu-Feng Qing   +11 more
doaj   +1 more source

MicroRNA-223 Suppresses IL-1β and TNF-α Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome

Frontiers in Pharmacology, 2021
Introduction: MicroRNA-223 (MiR-223) serves as an important regulator of inflammatory and immune responses and is implicated in several auto-inflammatory disorders.
Quan-Bo Zhang, Quan-Bo Zhang, Dan Zhu, Dan Zhu, Dan Zhu, Fei Dai, Fei Dai, Yu-Qin Huang, Yu-Qin Huang, Jian-Xiong Zheng, Jian-Xiong Zheng, Yi-Ping Tang, Yi-Ping Tang, Zeng-Rong Dong, Zeng-Rong Dong, Xia Liao, Xia Liao, Yu-Feng Qing, Yu-Feng Qing   +18 more
doaj   +1 more source

Interrelationships between hyperuricemia, metabolic syndrome and chronic kidney disease in patients with diabetes mellitus [PDF]

Archives of the Balkan Medical Union, 2020
Introduction. Hyperuricemia is a strong predictor of an altered metabolic status. There are complex interrelationships between hyperuricemia, type 2 diabetes mellitus (T2DM), metabolic syndrome (MS) and chronic kidney disease (CKD).
Adriana BAIDOG, Simona BUNGAU, Tapan BEHL, Ioana RATIU, Raluca A. CORB ARON, Francesca URSU, Liviu LAZAR, Cosmin M. VESA   +7 more
doaj   +1 more source