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Evolution of hypervirulence in Klebsiella [PDF]

Nature Reviews Microbiology, 2015
Naomi Attar
exaly   +2 more sources

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Hypervirulent Klebsiella pneumoniae

New England Journal of Medicine, 2021
Hypervirulent Klebsiella pneumoniae A 45-year-old man presented with eye pain and fever. Imaging showed multiple organ abscesses.
Qiong, Zou, Yang, Li
openaire   +2 more sources

The emergence of ‘hypervirulence’ in Clostridium difficile

International Journal of Medical Microbiology, 2010
The impact of Clostridium difficile-associated disease (CDAD) in healthcare settings throughout the developed world is considerable in terms of mortality, morbidity, and disease management. The incidence of CDAD has risen dramatically since the turn of this century, concomitant with the emergence of so-called hypervirulent strains which are thought to ...
Sarah A Kuehne, Nigel P Minton
exaly   +3 more sources

Hypervirulent Klebsiella pneumoniae detection methods: a minireview

Archives of Microbiology, 2023
Hypervirulent Klebsiella pneumoniae (hvKp), characterized by high virulence and epidemic potential, has become a global public health challenge. Therefore, improving the identification of hvKp and enabling earlier and faster detection in the community to support subsequent effective treatment and prevention of hvKp are an urgent issue. To address these
Qi-Bin, Zhang, Peng, Zhu, Shun, Zhang, Yan-Jing, Rong, Zuo-An, Huang, Li-Wan, Sun, Ting, Cai   +6 more
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Hypervirulence and pathogen fitness

Trends in Microbiology, 2003
Historically, pathogenesis research has focused on the identification and characterization of virulence factors. More recently, 'anti-virulence' genes have been discovered. Mutations in these loci result in a hypervirulent phenotype, as measured by a lower lethal dose, a colonization advantage, reduced clearance or decreased survival time of the host ...
Amy K, Foreman-Wykert, Jeff F, Miller
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Evolutionary transition of hypervirulent Klebsiella pneumoniae to multidrug-resistant hypervirulent Klebsiella pneumoniae: Indian experience

Indian Journal of Medical Microbiology
An emerging pathotype of Klebsiella pneumoniae, initially identified in Southeast Asian countries, has now spread to multiple countries, including India. These convergent strains, carrying both resistance and virulence determinants, are classified as multidrug-resistant Hypervirulent Klebsiella pneumoniae (MDR-HvKp).
Sanika Mahesh Kulkarni, Jobin John Jacob, V. Aravind, T. Praveen, Karthik Gunasekaran, Binesh Lal Y, Kamini Walia, Balaji Veeraraghavan   +7 more
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Seven hypervirulent ST380 Klebsiella pneumoniae septic localizations

Médecine et Maladies Infectieuses, 2017
International ...
Hentzien, Maxime, Rosman, J., Decré, D., Brenkle, K., Mendes-Martins, L., Mateu, P.   +5 more
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Primary osteomyelitis caused by hypervirulent Klebsiella pneumoniae

The Lancet Infectious Diseases, 2016
Klebsiella pneumoniae is the most clinically relevant species of this genus, known to cause both community-acquired and nosocomial infections worldwide. In the past two decades, a distinct hypervirulent strain of K pneumoniae, characterised by its hypermucoviscous phenotype, has emerged as a clinically significant pathogen responsible for highly ...
Bonnie C, Prokesch, Michael, TeKippe, Jiwoong, Kim, Prithvi, Raj, Erin McElvania, TeKippe, David E, Greenberg   +5 more
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Pediatric hypervirulent Klebsiella pneumoniae septic arthritis

Pediatrics International, 2016
AbstractCases of infection with hypervirulent Klebsiella pneumoniae are gradually increasing in number, and cause life‐threatening community‐acquired infection even in immunocompetent patients. A 14‐year‐old boy developed septic hip arthritis due to hypervirulent K. pneumoniae (sequence type 23, serotype K1, magA positive). The patient initially seemed
Shun, Kishibe, Yusuke, Okubo, Saeko, Morino, Shintaro, Hirotaki, Tomoyuki, Tame, Kotaro, Aoki, Yoshikazu, Ishii, Norikazu, Ota, Satoshi, Shimomura, Hiroshi, Sakakibara, Toshiro, Terakawa, Yuho, Horikoshi   +11 more
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Biodiversity and hypervirulence of Listeria monocytogenes

Nature Genetics, 2016
The integration of large, well-sampled collections of bacterial isolates with genomics and experimental methods provides opportunities for 'top-down' discovery of the genetic basis of phenotypes of interest. In a new report, the authors apply this approach to investigate the heterogeneity in manifestations of disease caused by Listeria monocytogenes ...
Yonatan H Grad, Sarah M Fortune
openaire   +1 more source