Results 41 to 50 of about 281 (158)
Journal of Biophotonics, Volume 18, Issue 6, June 2025.Photoactivated chemotherapy (PACT), an oxygen‐independent light‐based therapy, utilizes chemotherapeutic regimens that remain inert until exposed to light, allowing target‐specific activation while minimizing off‐target toxicity. The integration of these techniques has the potential to improve selectivity and yield synergistic cytotoxic effects that ...
Nkune Williams Nkune, Heidi Abrahamse
wiley +1 more source
Macromolecular Materials and Engineering, Volume 310, Issue 5, May 2025.Electrospun nanofibers provide a unique platform for photosensitizers, due to their large surface area and biocompatibility, improving both loading efficiency and controlled release. The photosensitizer‐modified nanofibers are activated upon light exposure, and produce reactive oxygen species to treat cancer, pathogen infections, and wounds.
Aslı Eldem +3 more
wiley +1 more source
Design of Aromatic Interaction Networks in a Protein Cage Modulated by Fluorescent Ligand Binding
Advanced Science, Volume 12, Issue 15, April 17, 2025.The study presents a novel system designed to control protein dynamics by orientational changes of aromatic residues triggered by ligand binding. By creating aromatic pockets within protein cages and binding fluorescent molecules via π–π interactions, the study achieves cooperative conformational change verified through X‐ray crystallography.
Yuki Hishikawa +10 more
wiley +1 more source
First Synthesis of Methylated Hypocrellin and Its Fluorescent Excited State: A Cautionary Tale
, 2016 Methylated hypocrellins were obtained and characterized by satisfactory 1HNMR, UV−vis, IR, and mass data, and their absorption and fluorescence emission spectra were studied. A previous report of methylated hypocrellin (J. Phys. Chem.
Shangjie Xu (3033891) +3 more
core +1 more source
Cell death: The underlying mechanisms of photodynamic therapy for skin diseases
Interdisciplinary Medicine, Volume 3, Issue 2, March 2025.Photodynamic therapy has significant potential in the treatment of skin diseases though it has some limitations. A thorough understanding of the underlying mechanism is integral to solving these problems. This review focuses on the induction of cell death and its relevant pathways.
Haoxin Li +9 more
wiley +1 more source
Interdisciplinary Medicine, Volume 2, Issue 4, October 2024.This review focuses exclusively on a plant‐derived photosensitizing drug‐hypocrellin for its chemical modification and its significant potential in biomedical applications. Hypocrellin is an ideal candidate due to its straightforward preparation and purification processes, high phototoxicity, low toxicity in the absence of light, and rapid metabolism ...
Ying'ao Wu, Xiong Yin, Min Li
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Photochemistry of hypocrellin derivatives under aerobic conditions
Chinese Science Bulletin, 2000 To improve the red absorption and solubility of hypocrellin, we have synthesized a series of hypocrellin B derivatives. The photochemistry of these new compounds in anaerobic media has been investigated by using electronic paramagnetic resonance (EPR) and spectrophotometric methods.
Yuying He, An Jingyi, Lijin Jiang
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Atypical artificial cells: Novel biomimetic materials for combating cancer
Interdisciplinary Materials, Volume 3, Issue 5, Page 658-714, September 2024.Inherited from natural cells, artificial cells possess unique and complex structures, which demonstrate eminent advantages in combating cancer. The research and application may bring a promising future for cancer prevention, diagnosis, and treatment. At the same time, they provide new sparks for the development of next‐generation anticancer therapeutic
Zhao‐yang Ren +10 more
wiley +1 more source
Coupling of Large-Amplitude Side Chain Motions to the Excited-State H-Atom Transfer of Perylene Quinones: Application of Theory and Experiment to Calphostin C [PDF]
, 2001 The excited-state intramolecular H-atom transfer reactions of hypocrellins B and A are compared with those of calphostin C. On the basis of the results of transient absorption measurements and ab initio quantum mechanical calculations, it is concluded ...
Gordon, Mark +4 more
core
Engineering and Targeting Neutrophils for Cancer Therapy
Advanced Materials, Volume 36, Issue 19, May 9, 2024.This review summarizes the recent advances in engineering neutrophils and their derivatives as drug delivery carriers for enhanced tumor targeting and improved therapeutic efficacy. Targeting neutrophils for remodeling tumor microenvironment (TME) and reinvigorating anti‐tumor immunity provide a broad understanding of the potential application of ...
Jiahui Zhang +9 more
wiley +1 more source