Results 91 to 100 of about 29,698,539 (199)

CSF hypocretin-1 levels are normal in patients with amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis, 2008
Hypocretin (orexin) neurotransmission is not only crucially involved in the regulation of sleep and wake, but serves in multiple autonomic and cognitive functions as well. This is reflected in the widespread connections between the hypothalamic hypocretin neurons and the rest of the brain, such as dense projections to the frontal cortex.
van Rooij, F.G., Schelhaas, H.J., Lammers, G.J., Verbeek, M.M., Verbeek, M.M., Overeem, S.   +5 more
openaire   +5 more sources

Utility of measuring CSF hypocretin-1 level in patients with suspected narcolepsy

, 2020
Objectives: The patho-aetiology of narcolepsy Type I (NT1) is the loss of hypocretin-1 secreting neurons in the hypothalamus. Diagnostic criteria for NT1 include excessive daytime sleepiness (EDS) for at least three months not explained by any other ...
Riha, Renata L., Riha, Renata L, Maschauer, Emily L., Roguski, Amber, Canham, Robyn, Szmyd, Bartosz, Białasiewicz, Piotr, Gabryelska, Agata, Maschauer, Emily L, Morrison, Ian   +9 more
core   +1 more source

Attenuated orexinergic signaling underlies sleep–wake problems in a Mecp2-null mouse model of Rett syndrome

Neurobiology of Disease
Rett syndrome (RTT) is a severe neurodevelopmental disorder mainly caused by mutations in the X-linked gene encoding methyl-CpG–binding protein 2 (MeCP2).
Kotaro Yuge, Tomoyuki Takahashi, Yukie Kawahara, Yusuke Sakai, Takahiro Sato, Tatsuyuki Kakuma, Akinori Nishi, Toyojiro Matsuishi, Yushiro Yamashita   +8 more
doaj   +1 more source

The hypocretin system and psychiatric disorders.

, 2014
The hypocretin system is constituted by a small group of hypothalamic neurons with widespread connections within the entire central nervous system producing two neuropeptides involved in several key physiological functions such as the regulation of sleep
G. Plazzi, PLAZZI, GIUSEPPE, M. Magnani, C. Indrio, F. Pizza, C. Indrio, PIZZA, FABIO, M. Magnani   +7 more
core   +1 more source

Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice. [PDF]

Front Synaptic Neurosci, 2021
Tunisi L, D'Angelo L, Fernández-Rilo AC, Forte N, Piscitelli F, Imperatore R, de Girolamo P, Di Marzo V, Cristino L.   +8 more
europepmc   +1 more source

Normal hypocretin-1 (orexin-A) levels in the cerebrospinal fluid of patients with Huntington's disease

, 2005
A significant atrophy and loss of hypocretin neurons in the brains of human patients with Huntington's disease (HD) and in R6/2 mice have been reported. We included 10 patients with HD and 12 patients with chorea-like hyperkinetic movement disorders (non-
Meier, A., Meller, J., Mollenhauer, Brit, Cohrs, Stefan, Jordan, W., Otto, Markus, Rodenbeck, Andrea   +6 more
core   +1 more source

The hypocretin/orexin system in sleep disorders: preclinical insights and clinical progress

Nature and Science of Sleep, 2016
Matthew Chow, Michelle CaoDepartment of Psychiatry and Behavioral Sciences, Division of Sleep Medicine, Stanford University School of Medicine, Stanford, CA, USAAbstract: Much of the understanding of the hypocretin/orexin (HCRT/OX) system in sleep&ndash ...
Chow M, Cao M
doaj  

Increased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation

, 2004
Rat cisternal (CSF) hypocretin-1 in cerebrospinal fluid was measured after 6 or 96 It of REM sleep deprivation and following 24 It of REM sleep rebound. REM deprivation was found to increase CSF hypocretin-1 collected at zeitgeber time (ZT) 8 but not ZT0.
Sergio Tufik, Paulo J.F Martins, Lin Ling, Seiji Nishino, Machado, R. B., Tufik, S., Mario Pedrazzoli, Martins, PJF, Ling, L., Vania D'Almeida, Nishino, S., Ricardo B Machado, Mignot, E., D'Almeida, V, Emmanuel Mignot, Pedrazzoli, M.   +15 more
core   +1 more source

Adolescent alcohol exposure increases orexin-A/hypocretin-1 in the anterior hypothalamus. [PDF]

Alcohol, 2020
Amodeo LR, Liu W, Wills DN, Vetreno RP, Crews FT, Ehlers CL.   +5 more
europepmc   +1 more source

Biomarkers and genetic factors beyond hypocretin-1 in the diagnostics of narcolepsy

Journal of Clinical Sciences
Narcolepsy is a chronic sleep-wake disorder usually diagnosed by polysomnography, multiple sleep latency testing, and laboratory assessment. One such laboratory approach involves measuring hypocretin-1 in cerebrospinal fluid.
Beeravolu Harshith Reddy, Babaji Ghewade, Ulhas Jadhav, Vivek Dipakrao Alone   +3 more
doaj   +1 more source