Results 71 to 80 of about 29,698,539 (199)

Sleep Duration and Sun Exposure in Portuguese Children: Associations With Obesity Indicators

American Journal of Human Biology, Volume 38, Issue 9, September 2026.
Overview of the study design and main findings on the associations among sun exposure, sleep duration, and obesity indicators in Portuguese children. ABSTRACT Introduction Sleep duration, sun exposure, and obesity are important and potentially interconnected factors in child health.
Elizabete A. dos Santos, Aristides Machado‐Rodrigues, Daniela Rodrigues, Maria‐Raquel G. Silva, Helena Nogueira, Cristina Padez   +5 more
wiley   +1 more source

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, Volume 4, Issue 3, Page 229-247, September 2026.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

Narcolepsy Along with an Update

Türk Uyku Tıbbı Dergisi, 2015
Narcolepsy is the most common primary hypersomnia, which is caused by loss of hypocretin neurons. Hypocretin in the neurohypothalamus is of crucial role in the maintenance of awakeness. Narcolepsy is characterized by hypnagogic/hypnopompic hallucinations,
Kutluhan Yilmaz
doaj   +1 more source

Assessing mortality risk in narcolepsy: Evidence from population studies

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Narcolepsy is a chronic neurologic sleep disorder associated with excessive daytime sleepiness, cataplexy, and a higher prevalence of cardiovascular and psychiatric comorbidities. While these factors may predispose individuals to adverse events, observational studies evaluating mortality in narcolepsy have yielded inconsistent results.
Nawris Alhassan, Susmin Karki, Jagdish Lal   +2 more
wiley   +1 more source

Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: Pharmacological and behavioral genetics evidence

Frontiers in Behavioral Neuroscience, 2012
Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Jonathan eHollander, Don ePham, Christie eFowler, Paul J Kenny   +3 more
doaj   +1 more source

Salivary biomarkers in sleep‐related disorders

Sleep Research, Volume 3, Issue 3, Page 272-285, September 2026.
Abstract The exploration of salivary biomarkers has emerged as a promising avenue in the diagnosis and management of sleep‐related disorders, such as obstructive sleep apnea (OSA), insomnia, and sleep deprivation. Saliva is a noninvasive biofluid that contains a wealth of biological markers, reflecting both local and systemic physiological changes ...
Chuan Xiang Li, Yi Wang, Ying Ni Lin, Jun Qi Lin, Ya Ru Yan, Xian wen Sun, Liu Zhang, Shi Qi Li, Ning Li, Qing Yun Li   +9 more
wiley   +1 more source

Autoantibodies in Pandemrix®-induced narcolepsy: Nine candidate autoantigens fail the conformational autoantibody test

Autoimmunity, 2019
Study objectives: Narcolepsy type 1 (NT1) is a chronic sleep disorder characterized by loss of hypocretin-producing neurons. Increased NT1 incidence was observed in Sweden following mass-vaccination with Pandemrix®.
Madeleine Wallenius, Alexander Lind, Omar Akel, Emma Karlsson, Markus Svensson, Elin Arvidsson, Anita Ramelius, Carina Törn, Lars Palm, Åke Lernmark, Helena Elding Larsson   +10 more
doaj   +1 more source

Orexin 1 receptor antagonists in compulsive behaviour and anxiety: possible therapeutic use.

Frontiers in Neuroscience, 2014
Fifteen years after the discovery of hypocretin/orexin a large body of evidence has been collected supporting its critical role in the modulation of several regulatory physiological functions.
Emilio eMerlo-Pich, Sergio eMelotto
doaj   +1 more source

The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease

Brain Pathology, Volume 36, Issue 5, September 2026.
SIDT2‐immunoreactive inclusions are observed in the striatum, cerebral cortex, and hypothalamus in HD cases with different Vonsattel grades, and the frequency of SIDT2‐immunoreactive inclusions is associated with longer CAG repeats in the huntingtin gene.
Sanaz Gabery, Sofia Bergh, Chrisovalantou Huridou, Rachel Y. Cheong, Barbara Baldo, Paul Günther Scheunemann, Marie‐Louisa Schoebel, Linda Holmquist Mengelbier, Elisabet Englund, Catriona McLean, Carsten Saft, Deniz Kirik, Maria Björkqvist, Glenda Halliday, Elisabeth Petrasch‐Parwez, Huu Phuc Nguyen, Jonasz Jeremiasz Weber, Åsa Petersén   +17 more
wiley   +1 more source

The hypocretin/orexin system mediates the extinction of fear memories

, 2014
Anxiety disorders are often associated with an inability to extinguish learned fear responses. The hypocretin/orexin system is involved in the regulation of emotional states and could also participate in the consolidation and extinction of aversive ...
COSTA, GIULIA, Maldonado R, Berrendero F., Flores A, Valls Comamala V, Saravia R   +5 more
core   +2 more sources