Results 61 to 70 of about 29,698,539 (199)

Widespread white matter connectivity abnormalities in narcolepsy type 1: A diffusion tensor imaging study

NeuroImage: Clinical, 2019
Narcolepsy type 1 is caused by a selective loss of hypothalamic hypocretin-producing neurons, resulting in severely disturbed sleep-wake control and cataplexy. Hypocretin-producing neurons project widely throughout the brain, influencing different neural
Jari K. Gool, Rolf Fronczek, Alexander Leemans, Dennis A. Kies, Gert Jan Lammers, Ysbrand D. Van der Werf   +5 more
doaj   +1 more source

Lesions of the Suprachiasmatic Nucleus Eliminate the Daily Rhythm of Hypocretin-1 Release [PDF]

Sleep, 2004
Hypocretins (orexins) are involved in the sleep disorder narcolepsy. While hypocretin-1 has a daily oscillation, little is known regarding the relative contribution of circadian and homeostatic components on hypocretin release. The effect of lesions of the suprachiasmatic nucleus (SCN) on hypocretin-1 in the cerebrospinal fluid (CSF) was examined.SCN ...
Shengwen, Zhang, Jamie M, Zeitzer, Yasushi, Yoshida, Jonathan P, Wisor, Seiji, Nishino, Dale M, Edgar, Emmanuel, Mignot   +6 more
openaire   +2 more sources

Differences in Sleep Spindle Characteristics Between Children With Narcolepsy and Those With Other Causes of Subjective Sleepiness

Journal of Sleep Research, EarlyView.
ABSTRACT Central disorders of hypersomnolence are characterised by excessive daytime sleepiness. There has been growing interest in analysing sleep micro‐architecture, to further understand how sleep is affected by these conditions. We investigated if sleep spindle activity differed between children with narcolepsy, idiopathic hypersomnolence (IH) and ...
Marisha Shetty, Nushrika Kadam Kishore, Georgina Plunkett, Lauren C. Nisbet, Margot J. Davey, Gillian M. Nixon, Lisa M. Walter, Rosemary S. C. Horne   +7 more
wiley   +1 more source

Targeting Orexin 2 Receptors in Idiopathic Hypersomnia and Narcolepsy: A Randomised Phase 1b Proof‐Of‐Concept Study of Alixorexton

Journal of Sleep Research, EarlyView.
Orexin 2 receptor agonists have demonstrated that targeting the orexin system may address symptoms of central disorders of hypersomnolence. Results of this phase 1 study support the phase 2 clinical evaluation of oral alixorexton in patients with IH, NT2 and NT1.
Ronald R. Grunstein, Brendon J. Yee, Julia L. Chapman, Jian Eu Tai, Sheila Sivam, Craig Hopkinson, Daniel G. Smith, Alexandra Lovett, Shifang Liu, Sergey Yagoda, Bhaskar Rege   +10 more
wiley   +1 more source

Daridorexant‐ Case Report of Possible Side‐Effect in Rare Mitochondrial Disorder

Journal of Sleep Research, EarlyView.
ABSTRACT This case report describes a 40‐year‐old woman with maternally inherited diabetes and deafness (MIDD), a rare mitochondrial disorder, who received treatment with daridorexant due to severe chronic insomnia. She developed progression of her MIDD symptoms during treatment.
Sven Svedmyr, Joel Bergqvist
wiley   +1 more source

Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain

BMC Neuroscience, 2007
Background Narcolepsy causes dramatic behavioral alterations in both humans and dogs, with excessive sleepiness and cataplexy triggered by emotional stimuli.
Mignot Emmanuel, Nishino Seiji, Saetre Peter, Lindberg Julia, Jazin Elena   +4 more
doaj   +1 more source

Plant‐Based Production of Human Major Histocompatibility Complex Class II Molecules

Plant Biotechnology Journal, EarlyView.
ABSTRACT Major histocompatibility complex class II (MHC II) protein triggers adaptive immune responses by presenting antigens on antigen‐presenting cells (APCs) to be recognised by CD4+ T cells. Recombinant MHC II proteins are effective for the analysis of peptide‐binding interaction, detection of antigen‐specific T‐cells and clinical testing for donor‐
Abdelaziz Ramadan, Hiroko Miyadera, Kaho Oka, Kohei Ishikawa, Toshiya Kobayashi, Misaki Kobayashi, Mitsunori Shiroishi, Emiko Noguchi, Kenji Miura   +8 more
wiley   +1 more source

Cerebrospinal fluid melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) in Alzheimer's disease. [PDF]

PLoS ONE, 2013
Ancillary to decline in cognitive abilities, patients with Alzheimer's disease (AD) frequently suffer from behavioural and psychological symptoms of dementia (BPSD).
Frank M Schmidt, Juergen Kratzsch, Hermann-Josef Gertz, Mandy Tittmann, Ina Jahn, Uta-Carolin Pietsch, Udo X Kaisers, Joachim Thiery, Ulrich Hegerl, Peter Schönknecht   +9 more
doaj   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells. [PDF]

PLoS ONE, 2017
Narcolepsy is a rare neurologic disorder characterized by excessive daytime sleepiness, cataplexy and disturbed nocturnal sleep patterns. Narcolepsy type 1 (NT1) has been shown to result from a selective loss of hypothalamic hypocretin-secreting neurons ...
Michel Lecendreux, Guillaume Churlaud, Fabien Pitoiset, Armelle Regnault, Tu Anh Tran, Roland Liblau, David Klatzmann, Michelle Rosenzwajg   +7 more
doaj   +1 more source