Results 51 to 60 of about 29,698,539 (199)

Experimental sickness reduces hypocretin receptor 1 expression in the lateral hypothalamus and ventral tegmental area of female mice

, 2023
Recent studies have focused on how sickness behaviours, including lethargy, are coordinated in the brain in response to peripheral infections. Decreased hypocretin (orexin) signalling is associated with lethargy and previous research suggests that ...
Kornum, Birgitte Rahbek, Kolmos, Mie Gunni, Justinussen, Jessica Lauren, Arribas, Alba Pérez   +3 more
core   +1 more source

The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.

PLoS ONE, 2022
Here we show that central administration of pyroglutamylated arginine-phenylamine-amide peptide (QRFP/26RFa) increases both food intake and locomotor activity, without any significant effect on energy expenditure, thermogenesis or reward.
Chris Cook, Nicolas Nunn, Amy A Worth, David A Bechtold, Todd Suter, Susan Gackeheimer, Lisa Foltz, Paul J Emmerson, Michael A Statnick, Simon M Luckman   +9 more
doaj   +1 more source

COVID‐19–Induced Narcolepsy Type I With Cataplexy: A Short Report

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy type I is a rare neurological sleep disorder characterised by chronic excessive daytime sleepiness, cataplexy, and low orexin (hypocretin) levels. Infection with SARS‐CoV‐2 has been linked to neurological and neuropsychiatric sequelae, but cases of post‐COVID narcolepsy remain extremely uncommon.
Torsten Vinding Merinder, Martin Langeskov‐Christensen, Filip Kirov   +2 more
wiley   +1 more source

Overview of orexin/ hypocretin system [PDF]

, 2012
A series of recent studies has established the orexin/hypocretin system as a critical regulator of sleep/wake states. Its deficiency results in the sleep disorder narcolepsy in humans, dogs, and rodents.
60251055, Sakurai, Takeshi, 20296552, 259, Mieda, Michihiro, Michihiro Mieda, Takeshi Sakurai   +6 more
core   +1 more source

Effects of single and dual hypocretin-receptor blockade or knockdown of hypocretin projections to the central amygdala on alcohol drinking in dependent male rats

Addiction Neuroscience, 2022
Hypocretin/orexin (HCRT) is a neuropeptide that is associated with both stress and reward systems in humans and rodents. The different contributions of signaling at hypocretin-receptor 1 (HCRT-R1) and hypocretin-receptor 2 (HCRT-R2) to compulsive alcohol
Gabriel M. Aldridge, Tyler A. Zarin, Adam J. Brandner, Olivier George, Nicholas W. Gilpin, Vez Repunte-Canonigo, Pietro Paolo Sanna, George F. Koob, Leandro F. Vendruscolo, Brooke E. Schmeichel   +9 more
doaj   +1 more source

Diagnostic Value of Psychomotor Vigilance Task for Severe Sleep Inertia in Idiopathic Hypersomnia Versus Other Sleep Disorders Without Sleep Inertia

Journal of Sleep Research, EarlyView.
Diagnostic Value of PVT for Severe Sleep Inertia in Idiopathic Hypersomnia. ABSTRACT Sleep inertia impairs performance upon awakening and may be assessed using the psychomotor vigilance task (PVT). This study aimed to determine optimal PVT lapse cut‐offs at awakening to objectively measure sleep inertia by comparing patients with idiopathic hypersomnia
Elisa Evangelista, Alexandre Derré, Lucie Barateau, Anna Laura Rassu, Sofiene Chenini, Isabelle Jaussent, Yves Dauvilliers   +6 more
wiley   +1 more source

Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture [PDF]

, 2007
We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1^-/-(orexin) mice showed reduced responsiveness to GABA_A receptor agonists due to a ...
Ken-ichi Yagami, Bernard Bettler, Thomas Kilduff, Satoshi Kunita, Hitomi Takahira, Taizo Matsuki, Mika Nomiyama, Takeshi Sakurai, Noriko Hirashima, Satoru Takahashi, Masashi Yanagisawa   +10 more
core  

Hypocretin/Orexin Excites Hypocretin Neurons via a Local Glutamate Neuron—A Potential Mechanism for Orchestrating the Hypothalamic Arousal System [PDF]

, 2002
Neurons that release hypocretin/orexin modulate sleep, arousal, and energy homeostasis; the absence of hypocretin results in narcolepsy. Here we present data on the physiological characteristics of these cells, identified with GFP in transgenic mouse ...
Li, Ying, Sakurai, Takeshi, Gao, Xiao-Bing, van den Pol, Anthony N.   +3 more
core   +1 more source

Postmortem Evidence of CRH Neuron Reduction in Narcolepsy Without Cataplexy With Borderline Hypocretin‐1 Levels

Journal of Sleep Research, EarlyView.
ABSTRACT Narcolepsy is classified as type 1 (NT1) or type 2 (NT2) mainly according to hypocretin deficiency rather than cataplexy. While CRH neuron loss in the PVN has been described in NT1, it remains unclear whether similar changes occur in narcolepsy without cataplexy.
Ling Shan, Suzan Linssen, Rolf Fronczek, Lucie Barateau, Christelle Peyron, Yves Dauvilliers   +5 more
wiley   +1 more source

Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats [PDF]

, 2008
\ud RATIONALE:\ud \ud Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking.
Stephanie L. Borgland, Pia Steensland, Taha, Sharif, Steensland, Pia, Jeffrey A. Simms, Sharif A. Taha, Selena E. Bartlett, Richards, Jemma, Bonci, Antonello, Bartlett, Selena, Borgland, Stephanie, Jemma K. Richards, Antonello Bonci, Simms, Jeffrey   +13 more
core   +1 more source