Results 31 to 40 of about 29,698,539 (199)
Hypocretin‐1 Dose‐Dependently Modulates Maternal Behaviour in Mice [PDF]
Journal of Neuroendocrinology, 2006 Increases in neuronal activity of hypocretin (HCRT), a peptide involved in arousal, and in HCRT‐1 receptor mRNA expression have recently been identified in association with lactation. HCRT is released within brain regions regulating maternal behaviour and it is possible that increased HCRT neurotransmission during lactation supports maternal care.
K L, D'Anna, S C, Gammie
openaire +2 more sources
Pre-treatment of blood samples reveal normal blood hypocretin/orexin signal in narcolepsy type I [PDF]
, 2021 The hypocretin/orexin system regulates arousal through central nervous system mechanisms and plays an important role in sleep, wakefulness and energy homeostasis.
Lorentzen, Marc P. +15 more
core +1 more source
Health-related quality of life in patients with narcolepsy types 1 and 2 from a Sleep Center in Brazil [PDF]
Arquivos de Neuro-Psiquiatria, 2020 Introduction: Narcolepsy patients have higher prevalence of comorbidities, such as obesity, depression, and pain. Narcolepsy symptoms and concomitant medical conditions can impact the daily activities of patients.
Renata Carvalho CREMASCHI +3 more
doaj +1 more source
Attention impairments and ADHD symptoms in adult narcoleptic patients with and without hypocretin deficiency. [PDF]
PLoS ONE, 2017 Attentional complaints are common in narcolepsy patients and can overlap with daytime sleepiness features. Few studies attempted to characterize attentional domains in narcolepsy leading to controversial results.
Marco Filardi +5 more
doaj +1 more source
Brief Exercise Enhances Blood Hypocretin-1 in Sedentary Men [PDF]
Journal of Sports Medicine & Doping Studies, 2014 The aim of this experiment was to test the effect of brief exercise on the concentration of plasma hypocretin-1, a peptide that regulates many physiological variables. Blood samples were collected from participants (men, n=6) before (time 0 min) and after (times 15 and 30 min) a cycle ergo meter exercise at 75 W for 15 min.
Messina G +6 more
openaire +2 more sources
PLoS ONE, 2014 Two experiments used vivo morpholinos to assess the role of orexin/hypocretin in ABA renewal of extinguished alcohol seeking. Rats were trained to respond for alcoholic beer in a distinctive context, A, and then extinguished in a second distinctive ...
Asheeta A Prasad, Gavan P McNally
doaj +1 more source
Annals of Neurology, EarlyView.Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau +8 more
wiley +1 more source
Pituitary Macrotumor Causing Narcolepsy‐Cataplexy in a Dachshund
Journal of Veterinary Internal Medicine, 2017 Familial narcolepsy secondary to breed‐specific mutations in the hypocretin receptor 2 gene and sporadic narcolepsy associated with hypocretin ligand deficiencies occur in dogs.
S. Schmid +4 more
doaj +1 more source
Modulation of Respiratory Activity by Hypocretin-1 (Orexin A) In Situ and In Vitro [PDF]
, 2009 Release of hypocretins (orexins) by neurons in the lateral hypothalamus is an important contributor to arousal state, thermoregulation, feeding behavior, and has recently been proposed to play a role in breathing and central chemosensitivity. Using the in situ arterially perfused juvenile rat preparation, we determined the effect of hypocretin-1 (hcrt ...
Andrea, Corcoran +2 more
openaire +2 more sources
Angewandte Chemie, EarlyView.Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann +10 more
wiley +1 more source