Results 11 to 20 of about 29,698,539 (199)
IGFBP3 colocalizes with and regulates hypocretin (orexin). [PDF]
PLoS ONE, 2009 The sleep disorder narcolepsy is caused by a vast reduction in neurons producing the hypocretin (orexin) neuropeptides. Based on the tight association with HLA, narcolepsy is believed to result from an autoimmune attack, but the cause of hypocretin cell ...
Makoto Honda +14 more
doaj +2 more sources
CSF hypocretin-1 levels are normal in multiple-system atrophy
Parkinsonism & Related Disorders, 2008 Sleep disturbances occur in 70% of the patients with multiple system atrophy (MSA). Disturbances of the hypothalamic hypocretin neurotransmission have been suggested as a possible cause. Since a systematic study of CSF hypocretin-1 levels in MSA has not yet been performed, we analysed CSF hypocretin-1 concentrations in 6 MSA-P and 6 MSA-C patients and ...
Abdo, W.F. +7 more
openaire +4 more sources
Narcolepsy Type 1: Should We Only Target Hypocretin Receptor 2?
Clinical and Translational Neuroscience, 2023 Nearly 25 years have passed since the ground-breaking discovery that hypocretin deficiency underlies human narcolepsy with cataplexy. Over time, it has become increasingly evident that hypocretin deficiency goes beyond the conventional core symptoms, or ...
Rolf Fronczek, Gert Jan Lammers
doaj +2 more sources
Intermediate hypocretin-1 cerebrospinal fluid levels and typical cataplexy: their significance in the diagnosis of narcolepsy type 1. [PDF]
Sleep, 2022 STUDY OBJECTIVES: The diagnosis of narcolepsy type 1 (NT1) is based upon the presence of cataplexy and/or a cerebrospinal fluid (CSF) hypocretin-1/orexin-A level ≤ 110 pg/mL.
van der Hoeven AE +7 more
europepmc +2 more sources
El sistema hipocretina / orexina en la fisiopatología de las hipersomnias de origen central [PDF]
, 2007 [spa] INTRODUCCIÓN. El sistema hipocretina/orexina es un sistema neurotransmisor hipotalámico con funciones promotoras de la vigilia. La narcolepsia, enfermedad caracterizada por una excesiva somnolencia diurna y manifestaciones anormales del sueño REM ...
Martínez Rodríguez, José Enrique
core +6 more sources
Hypocretin-1 and GABA in the Pontine Reticular Formation Interact to Promote Wakefulness. [PDF]
Hypocretin-1 and hypocretin-2 are wake-promoting neuropeptides that are exclusively synthesized in the lateral hypothalamus. Hypocretin deficiency underlies the sleep disorder narcolepsy, which is characterized by excessive daytime sleepiness and ...
Brevig, Holly N.
core +7 more sources
Progress of autonomic disturbances in narcolepsy type 1
Frontiers in Neurology, 2023 Narcolepsy type 1 is a kind of sleep disorder characterized by a specific loss of hypocretin neurons in the lateral hypothalamus and reduced levels of hypocretin-1 in the cerebrospinal fluid.
Ying Wang +6 more
doaj +1 more source
Cerebrospinal Fluid Hypocretin and Nightmares in Dementia Syndromes
Dementia and Geriatric Cognitive Disorders Extra, 2021 Background/Aims: Hypocretin promotes wakefulness and modulates REM sleep. Alterations in the hypocretin system are increasingly implicated in dementia.
Lynn Marie Trotti +4 more
doaj +1 more source
Cell Reports, 2023 Summary: The hypothalamus plays a crucial role in the modulation of social behavior by encoding internal states. The hypothalamic hypocretin/orexin neurons, initially identified as regulators of sleep and appetite, are important for emotional and ...
Matthew Dawson +8 more
doaj +1 more source
Molecular Metabolism, 2023 Objective: The present study tests the hypothesis that changes in the glucose sensitivity of lateral hypothalamus (LH) hypocretin/orexin glucose-inhibited (GI) neurons following weight loss leads to glutamate plasticity on ventral tegmental area (VTA ...
Suraj B. Teegala +8 more
doaj +1 more source