Results 21 to 30 of about 29,698,539 (199)
Neurotrauma Reports, 2023 Blast-induced traumatic brain injury (bTBI) frequently results in sleep and circadian rhythm disturbances. We have investigated whether dysregulation of circadian rhythm after bTBI is mediated by dysregulation of clock genes in the hypothalamus and ...
Manoj Govindarajulu +4 more
doaj +1 more source
Hypocretin and brain β-amyloid peptide interactions in cognitive disorders and narcolepsy
Frontiers in Aging Neuroscience, 2014 Objective: To examine relationships between cerebrospinal fluid (CSF) Alzheimer’ disease (AD) biomarkers and hypocretin-1 levels in patients with cognitive abnormalities and hypocretin-deficient narcolepsy-cataplexy (NC), estimate diagnostic accuracy ...
Yves A Dauvilliers +4 more
doaj +1 more source
Human hypocretin-deficient narcolepsy - aberrant food choice due to impaired taste? [PDF]
Sleep ScienceAuthors demonstrate that patients with narcolepsy type 1 (N1) have more tendency of eat salty snacks after satiety than health volunteers. A few mechanisms to explain the weight gain have been discussed in narcolepsy.
Giselle de Martin Truzzi +2 more
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Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis [PDF]
Neurology, 2004 Idiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with idiopathic narcolepsy.
S, Overeem +6 more
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The wake-promoting effects of hypocretin-1 are attenuated in old rats [PDF]
Neurobiology of Aging, 2011 Disruption of sleep is a frequent complaint among elderly humans and is also evident in aged laboratory rodents. The neurobiological bases of age-related sleep/wake disruption are unknown. Given the critical role of the hypocretins in sleep/wake regulation, we sought to determine whether the wake-promoting effect of hypocretin changes with age in ...
MORAIRTY, Stephen R +4 more
openaire +3 more sources
Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers [PDF]
The Journal of Neuroscience, 2009 Orexin A/hypocretin-1 (oxA/hcrt-1) is known to be a modulator of dopamine-dependent neuronal activity and behaviors. However, the role of this system in driving motivated behaviors remains poorly understood. Here, we show that orexin/hypocretin receptor-1 (ox/hcrt-1R) signaling is important for motivation for highly salient, positive reinforcement ...
Stephanie L, Borgland +8 more
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The hypocretins (orexins) mediate the “phasic” components of REM sleep: A new hypothesis
Sleep Science, 2014 In 1998, a group of phenotypically distinct neurons were discovered in the postero-lateral hypothalamus which contained the neuropeptides hypocretin 1 and hypocretin 2 (also called orexin A and orexin B), which are excitatory neuromodulators ...
Pablo Torterolo, Michael H. Chase
doaj +3 more sources
Traditional biomarkers in narcolepsy: experience of a Brazilian sleep centre
Arquivos de Neuro-Psiquiatria, 2010 This study was thought to characterized clinical and laboratory findings of a narcoleptic patients in an out patients unit at São Paulo, Brazil. METHOD: 28 patients underwent polysomnographic recordings (PSG) and Multiple Sleep Latency Test (MSLT) were ...
Fernando Morgadinho Santos Coelho +7 more
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Polymorphisms in hypocretin receptors and insomnia
Sleep Science, 2013 Hypocretin system has been described as one of the most important neurotransmission systems involved in the waking process. The system’s lack of function, caused by mutation or neuron death, leads to sharp sleepiness in mammals. It has been proposed that
Lhoyane Moraes Oliveira +5 more
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The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. [PDF]
PLoS ONE, 2012 Recent studies have implicated the hypocretin/orexinergic system in reward-seeking behavior. Almorexant, a dual orexin/hypocretin R(1) and R(2) receptor antagonist, has proven effective in preclinical studies in promoting sleep in animal models and was ...
Subhashini Srinivasan +8 more
doaj +1 more source