Hypocretin‐1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model [PDF]
Advanced ScienceCognitive dysfunction is not only a common symptom of major depressive disorder, but also a more common residual symptom after antidepressant treatment and a risk factor for chronic and recurrent disease.
Jing Lu
exaly +4 more sources
Sexually Dimorphic Changes of Hypocretin (Orexin) in Depression [PDF]
EBioMedicine, 2017 Background: Neurophysiological and behavioral processes regulated by hypocretin (orexin) are severely affected in depression. However, alterations in hypocretin have so far not been studied in the human brain. We explored the hypocretin system changes in
Rolf Fronczek, Aimin Bao, Dick Swaab
exaly +5 more sources
Increased immune complexes of hypocretin autoantibodies in narcolepsy. [PDF]
PLoS ONE, 2010 BACKGROUND: Hypocretin peptides participate in the regulation of sleep-wake cycle while deficiency in hypocretin signaling and loss of hypocretin neurons are causative for narcolepsy-cataplexy.
Aude Deloumeau +8 more
doaj +2 more sources
Inclusion of hypocretin-1 improved performance of poor sleep quality prediction for elderly patients with acute ischemic stroke: a prospective cohort study [PDF]
Frontiers in Aging NeuroscienceBackgroundHypocretin-1 is a vital neurotransmitter in regulating the sleep–wake cycle and provides neuroprotection against cerebral ischemia. We aims to develop a poor sleep quality predictive model for elderly population with acute ischemic stroke ...
Ting Fu +7 more
doaj +2 more sources
Hypocretin Levels in Sporadic and Familial Cases of Canine Narcolepsy
Neurobiology of Disease, 2001 Familial and sporadic forms of narcolepsy exist in both humans and canines. Mutations in the hypocretin receptor 2 gene (Hcrtr 2) cause canine familial narcolepsy.
Beth Ripley +2 more
exaly +3 more sources
The New *G29A and G1222A of HCRTR1, 5-HTTLPR of SLC6A4 Polymorphisms and Hypocretin-1, Serotonin Concentrations in Migraine Patients [PDF]
Frontiers in Molecular Neuroscience, 2018 Migraine is one of the most common primary headache disorders that affects 11% of the adult population. The disease is divided into two main clinical subtypes: migraine with aura (MA) and migraine without aura (MO).
Marta Kowalska +7 more
doaj +2 more sources
HPLC analysis of CSF hypocretin-1 in type 1 and 2 narcolepsy. [PDF]
Sci Rep, 2019 AbstractNarcolepsy is a chronic sleep disorder caused by a loss of hypocretin (hcrt) neurons in the hypothalamus. Cerebrospinal fluid (CSF) hcrt-1 measurement has been well established as a gold standard of narcolepsy diagnosis, although some portions of narcoleptic patients show normal hcrt-1 levels.
Sakai N +4 more
europepmc +4 more sources
Aquaporin‐4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders [PDF]
Annals of Clinical and Translational NeurologyNarcolepsy type 1 (NT1) is caused by the loss of hypocretin‐1 leading to excessive daytime sleepiness and cataplexy. Additionally, disrupted nighttime sleep has become an increasingly recognized feature of NT1.
Jonas Ranke +5 more
doaj +2 more sources
Narcolepsy: immunity, neural circuitry, and brain network reconfiguration [PDF]
Frontiers in ImmunologyIntroductionNarcolepsy is a rare sleep disorder characterized by cataplexy and excessive daytime sleepiness. The hallmark neuropathological feature is the selective loss of hypothalamic hypocretin (HCRT) neurons. This review systematically summarizes the
Jiajia Chen +4 more
doaj +2 more sources
Increased Hypocretin (Orexin) Plasma Level in Depression, Bipolar Disorder Patients
Frontiers in Psychiatry, 2021 As hypocretin can markedly affect neurophysiological and behavioural processes in mood disorders. However, few studies have measured changes in hypocretin levels in patients with mood disorders.
Haimei Li +21 more
doaj +1 more source