Results 41 to 50 of about 29,698,539 (199)

Olfactory Dysfunction and Hypocretin in Narcolepsy

Pediatric Neurology Briefs, 2008
CSF orexin A (hypocretin-1) is decreased or absent in narcoleptic patients with cataplexy.
J Gordon Millichap
doaj   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Narcolepsy: the impact of aging, hypocretin deficiency, and years of formal education in olfactory function and abdominal obesity

Arquivos de Neuro-Psiquiatria, 2021
Background: Narcolepsy is a disease resulting from the loss of hypocretin-producing cells or other dysfunctions of the hypocretinergic system. In addition to sleep disorders, affected patients may experience increased weight gain, olfactory changes, and ...
Giselle de Martin Truzzi, Maria Fernanda Naufel, Sergio Tufik, Fernando Morgadinho Coelho   +3 more
doaj   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Hypocretin: a promising target for the regulation of homeostasis

Frontiers in Neuroscience
Hypocretin, also known as orexin, is a hypothalamic neuropeptide that regulates essential physiological processes including arousal, energy metabolism, feeding behavior, and emotional states.
Yutong Wang, Yutong Wang, Su Fu, Jian Mao, Kun Cui, Hong Jiang, Hong Jiang   +6 more
doaj   +1 more source

Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far

Frontiers in Neuroscience, 2013
Emerging findings suggest the existence of a cross-talk between hypocretinergic and endocannabinoid systems. Although few studies have examined this relationship, the apparent overlap observed in the neuroanatomical distribution of both systems as well ...
África eFlores, Rafael eMaldonado, Fernando eBerrendero   +2 more
doaj   +1 more source

Narcolepsy and H1N1 influenza immunology a decade later: What have we learned?

Frontiers in Immunology, 2022
In the wake of the A/California/7/2009 H1N1 influenza pandemic vaccination campaigns in 2009-2010, an increased incidence of the chronic sleep-wake disorder narcolepsy was detected in children and adolescents in several European countries.
Sofia M. Buonocore, Robbert G. van der Most   +1 more
doaj   +1 more source

Ageing‐related modification of sleep and breathing in orexin‐knockout narcoleptic mice

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Narcolepsy type‐1 (NT1) is a lifelong sleep disease, characterised by impairment of the orexinergic system, with a typical onset during adolescence and young adulthood. Since the wake–sleep cycle physiologically changes with ageing, this study aims to compare sleep patterns between orexin‐knockout (KO) and wild type (WT) control mice at ...
Stefano Bastianini, Sara Alvente, Chiara Berteotti, Viviana Lo Martire, Gabriele Matteoli, Elena Miglioranza, Alessandro Silvani, Giovanna Zoccoli   +7 more
wiley   +1 more source

Cerebrospinal fluid hypocretin-1 levels during the active period of cluster headache

, 2011
BACKGROUND: Hypocretins (orexins) are hypothalamic neuropeptides which are involved in a wide range of physiological processes in mammals including central pain processing.
Claudio L Bassetti, Pizza, Fabio, Nicodemo, Marianna, Grimaldi D., Cevoli S., Daniela Grimaldi, Valko, Philipp O, Cevoli, S, Nicodemo, M, Pierangeli, Giulia, Giulia Pierangeli, Pierangeli, G, Christian R Baumann, Pasquale Montagna, Nicodemo M., Favoni, Valentina, Valko P. O., Montagna, P, Montagna, Pasquale, Grimaldi, D, Cortelli, P, Sabina Cevoli, Favoni, V, Valentina Favoni, Baumann C. R., Fabio Pizza, Bassetti C. L., Bassetti, C L, Cevoli, Sabina, Cortelli, Pietro, Grimaldi, Daniela, Baumann, C R, Marianna Nicodemo, Montagna P., Bassetti, Claudio L, Philipp O Valko, Pizza, F, Baumann, Christian R, Pietro Cortelli, Valko, P O   +39 more
core   +1 more source