Results 41 to 50 of about 4,456 (153)

Factor XIII Supplementation in Postpartum Hemorrhage: From Biological Rationale to Clinical Implementation

American Journal of Hematology, Volume 101, Issue 4, Page 794-806, April 2026.
ABSTRACT Postpartum hemorrhage (PPH) remains the leading cause of preventable maternal mortality despite standard interventions. Recent fibrinogen trials failed to improve outcomes, prompting interest in coagulation factor XIII (FXIII). FXIII functions as “molecular cement,” cross‐linking fibrin and stabilizing clots.
Jeremy W. Jacobs, Elizabeth A. Abels, Brian D. Adkins, Garrett S. Booth, Victoria Costa, Sheharyar Raza, Michelle Simon, Jennifer S. Woo, Allison P. Wheeler   +8 more
wiley   +1 more source

Severe haemorrhagic diathesis due to acquired hypofibrinogenemia in a patient with early T-cell precursor acute lymphoblastic leukaemia/lymphoma: a case report

Frontiers in Cardiovascular Medicine
The most frequent haematological malignancy associated with acquired hypo/dysfibrinogenemia is multiple myeloma. We present an unusual case of severe haemorrhagic diathesis due to acquired hypofibrinogenemia in a patient with early T-cell precursor acute
Luca Spiezia, Marcello Riva, Carmela Gurrieri, Elena Campello, Paolo Simioni   +4 more
doaj   +1 more source

Prevalence and Diagnostic Challenge of Hemophagocytic Lymphohistiocytosis Syndrome in Critically Ill Patients

European Journal of Haematology, Volume 116, Issue 4, Page 380-390, April 2026.
ABSTRACT Background Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome. It is a severe condition with a challenging diagnosis in the intensive care unit (ICU), for which current recommendations rely on fulfilling five of eight HLH‐2004 criteria.
Claire Queffeulou, Mathieu Bellal, Suzanne Goursaud, Sylvain Chantepie, Damien du Cheyron   +4 more
wiley   +1 more source

Classification of Platelet‐Activating Anti‐Platelet Factor 4 Disorders

International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 259-271, April 2026.
ABSTRACT Introduction The prototypic anti‐platelet factor 4 (PF4) disorder—heparin‐induced thrombocytopenia and thrombosis (HITT)—features immunoglobulin G (IgG) class antibodies that activate platelets, monocytes, and neutrophils in a mainly heparin‐dependent fashion via Fcγ receptor‐dependent cellular activation.
Theodore E. Warkentin
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Massive hemopericranium following trivial trauma in a child with hypofibrinogenemia: A case report and review of the literature

Indian Journal of Neurosurgery, 2014
Subgaleal hematoma is a potentially life-threatening extracranial bleed that occurs most commonly in neonates after difficult instrumental deliveries. Its occurrence beyond the neonatal period is rare and is often associated with head trauma involving ...
Rajeev Sharma, Laxmi Naraian Gupta
doaj   +1 more source

Disseminated Invasive Aspergillosis in a Young Patient With Chronic Alcohol Use and Seemingly Preserved Immunocompetence: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Invasive aspergillosis, though typically seen in immunocompromised patients, can also affect immunocompetent individuals and mimic pulmonary malignancy. This case highlights the importance of considering fungal infections in the differential diagnosis of chronic respiratory symptoms, particularly in patients with risk factors such as heavy ...
Kumail Khandwala, Hiba Sawliha Syed, Shayan Sirat Maheen Anwar, Sehar Suleman, Khabab Abbasher Hussien Mohamed Ahmed   +4 more
wiley   +1 more source

Fibrinogen Concentrate for the Treatment of Thrombolysis-Associated Hemorrhage in Adult Ischemic Stroke Patients

Clinical and Applied Thrombosis/Hemostasis, 2020
In patients with ischemic stroke who receive systemic recombinant tissue plasminogen activator (rt-PA), the risk of secondary hemorrhage is 1-7%. Fibrinogen supplementation with cryoprecipitate is recommended in patients with rt-PA-associated symptomatic
Megan E. Barra PharmD, BCPS, BCCCP, Steven K. Feske MD, Katelyn W. Sylvester PharmD, BCPS, Charlene Ong MD, MPHS, Sarah E. Culbreth PharmD, BCPS, Patricia Krause PharmD, BCPS, Galen V. Henderson MD, Eva Rybak PharmD, BCPS   +7 more
doaj   +1 more source

A Case of Severe Pre‐Eclampsia Complicated by HELLP Syndrome and Extensive Hepatic Infarction

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Extensive hepatic infarction is a rare but potentially fatal complication of HELLP syndrome and is often difficult to recognize because of nonspecific clinical manifestations. A 34‐year‐old woman developed HELLP syndrome shortly after cesarean delivery for severe pre‐eclampsia, presenting with oliguria, marked thrombocytopenia (50 × 109/L ...
Tiange Xia, Fei Gao, Fengming Liang, Yang Shao   +3 more
wiley   +1 more source

Adult‐Onset Still's Disease(AOSD) With Features Suggestive of Macrophages Activation Syndrome in Young Female: A Rare Case Report From Nepal

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Adult‐onset Still's disease (AOSD) is a rare, multisystem autoinflammatory disorder characterized by a classic triad of fever, evanescent rash, and arthritis with diagnostic challenges. We present a case of a previously healthy 22‐year‐old Nepalese female presented with a 1.5‐month history of progressive bilateral lower limb edema and a 13‐day
Sushil Silwal, Krishan Khang Mandal, Gaurav Parajuli, Krishna Adhikari   +3 more
wiley   +1 more source