Results 11 to 20 of about 19,540 (227)

Infections in Chronic Lymphocytic Leukemia: Evolving Risks and Prevention Strategies. [PDF]

Eur J Haematol
ABSTRACT Infections remain a leading cause of morbidity and mortality in patients with chronic lymphocytic leukemia (CLL), reflecting both intrinsic immune dysfunction and therapy‐related immunosuppression. The pathogenesis of immunodeficiency in CLL is multifactorial: neoplastic B cells impair humoral immunity, T cells are functionally exhausted, and ...
Martino EA, Caserta S, Vigna E, Bruzzese A, Amodio N, Lucia E, Olivito V, Labanca C, Mendicino F, Morabito F, Gentile M.   +10 more
europepmc   +2 more sources

Clinical Courses of IKAROS and CTLA4 Deficiencies: A Systematic Literature Review and Retrospective Longitudinal Study

Frontiers in Immunology, 2022
IKAROS and CTLA4 deficiencies are inborn errors of immunity and show similar clinical phenotypes, including hypogammaglobulinemia and autoimmune diseases (ADs).
Akihiro Hoshino, Akihiro Hoshino, Etsushi Toyofuku, Etsushi Toyofuku, Noriko Mitsuiki, Motoi Yamashita, Keisuke Okamoto, Michio Yamamoto, Kenji Kanda, Genki Yamato, Dai Keino, Yuri Yoshimoto-Suzuki, Junji Kamizono, Yasuhiro Onoe, Takuya Ichimura, Mika Nagao, Masaru Yoshimura, Koji Tsugawa, Toru Igarashi, Kanako Mitsui-Sekinaka, Yujin Sekinaka, Takehiko Doi, Takahiro Yasumi, Yozo Nakazawa, Masatoshi Takagi, Kohsuke Imai, Shigeaki Nonoyama, Tomohiro Morio, Sylvain Latour, Sylvain Latour, Hirokazu Kanegane   +30 more
doaj   +1 more source

Case report: Persistent hypogammaglobulinemia in thymoma-associated myasthenia gravis: the impact of rituximab or Good's syndrome?

Frontiers in Neurology, 2023
IntroductionRituximab (RTX) showed good efficacy and safety for patients with myasthenia gravis. However, the percentage of peripheral CD20+ B cell may be absent for years after low dose of RTX treatment.
Jingru Ren, Jianchun Wang, Ran Liu, Jing Guo, Yan Yao, Jingjing Luo, Hongjun Hao, Feng Gao   +7 more
doaj   +1 more source

Carbamazepine-induced hypogammaglobulinemia [PDF]

Seizure, 2012
Carbamazepine is used to control seizures. Its common side effects are sleep disorders, anorexia, nausea, vomiting, polydipsia, irritability, ataxia, and diplopia. Involvement of the immune system is rare, and few cases of decreased immunoglobulin levels have been reported.
Ozaras, Resat, GÖKSÜGÜR, NADİR, Canbakan, Billur, Tabak, Omur, Eroglu, Saliha, Ozaras, Nihal   +5 more
openaire   +3 more sources

Presence of Hypogammaglobulinemia – A Risk Factor of Mortality in Patients with Severe Sepsis, Septic Shock, and SIRS

Prague Medical Report, 2013
In this retrospective study we assessed the frequency of hypogammaglobulinemia in 708 patients with SIRS, severe sepsis and septic shock. We evaluated the relationship between hypogammaglobulinemia IgG, IgM and 28 day mortality. Total of 708 patients and
Miroslav Průcha, R. Zazula, I. Herold, M. Dostál,  T. Hyánek, G. Bellingan   +5 more
doaj   +1 more source

A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation [PDF]

, 2015
Lymphocyte apoptosis is mainly induced by either death receptor-dependent activation of caspase-8 or mitochondria-dependent activation of caspase-9. Mutations in caspase-8 lead to autoimmunity/lymphoproliferation and immunodeficiency. This work describes
Boggio, E, Cappellano, G, Chiocchetti, A., Clemente, N, Dianzani, C, Dianzani, I, Dianzani, U, Gigliotti, Cl, Notarangelo, Ld, Orilieri, E, Pignata, C, Quinti, Isabella, Ramenghi, U, Santoro, C, Toth, E, Valletti, Pa   +15 more
core   +2 more sources

Variable clinical characteristics and laboratory results in five patients with Chinese Good's syndrome (thymoma and hypogammaglobulinemia): an 8-year retrospective analysis in a university hospital in China

BMC Immunology, 2021
Background Good's syndrome (GS) is a rare secondary immunodeficiency disease presenting as thymoma and hypogammaglobulinemia. Due to its rarity, the diagnosis of GS is often missed.
Jinyao Ni, Junwu Zhang, Yanxia Chen, Weizhong Wang, Jinlin Liu   +4 more
doaj   +1 more source

Common variable immunodeficiency disorder: a clinical case

Медицинская иммунология, 2021
Primary immunodeficiency is a rare congenital pathology associated with failure of immune system, manifested by disturbances of its functions. These defects lead to increased susceptibility of patients to various infectious agents, as well as the ...
E. A. Sobko, I. V. Demko, I. A. Soloveva, A. Yu. Kraposhina, N. V. Gordeeva, D. A. Anikin, N. S. Pronkina, O. P. Ischenko   +7 more
doaj   +1 more source

Rituximab-associated Hypogammaglobulinemia in pediatric patients with autoimmune diseases

Pediatric Rheumatology Online Journal, 2019
Background Despite the increased use of rituximab in treating pediatric patients with autoimmune diseases in the last decade, there are limited data on rituximab safety in those subjects who have a developing immune system. The objective of this study is
Amer M. Khojah, Michael L. Miller, Marisa S. Klein-Gitelman, Megan L. Curran, Victoria Hans, Lauren M. Pachman, Ramsay L. Fuleihan   +6 more
doaj   +1 more source

Successful treatment of rituximab-unresponsive elderly-onset neuromyelitis optica spectrum disorder and hypogammaglobulinemia with ofatumumab plus intravenous immunoglobulin therapy in a patient with mutant FCGR3A genotype: A case report

Frontiers in Immunology, 2022
BackgroundElderly-onset neuromyelitis optica spectrum disorder (NMOSD) is a rare entity that poses a therapeutic challenge. We report a case of elderly-onset NMOSD with mutant FCGR3A genotype who was successfully treated with ofatumumab after multiple ...
Weihe Zhang, Yujuan Jiao, Jinsong Jiao, Ming Jin, Dantao Peng   +4 more
doaj   +1 more source