Results 41 to 50 of about 127,164 (309)
Analysis on Research Status of Triterpenoids in Sporophore of Inonotus obliquus
Shipin gongye ke-ji, 2022 Inonotus obliquus is anatural plant fungal resource with a variety of biological activities. Triterpenoids are the main functional components. Because triterpenoids have excellent anticancer, hypoglycemic and antioxidant properties, the related research ...
Yan WANG +6 more
doaj +1 more source
Advanced Science, EarlyView.HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng +10 more
wiley +1 more source
DataSheet1_Synthesis and hypoglycemic activity of quinoxaline derivatives.PDF
, 2023 In this study, a new series of quinoxalinone derivatives (5a–5p, 6a–6n) was designed and its hypoglycemic activity was evaluated. The results showed that compounds 5i and 6b exhibited stronger hypoglycemic effects than the lead compounds and were ...
Weidong Jia (3549056) +5 more
core +1 more source
Advanced Science, EarlyView.Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Chunliang Zheng +4 more
wiley +1 more source
Effect of Chronic Administration of Justicia secunda Vahl in Mice Diabetized with Streptozotocin
DiabetologyCertain pharmacological properties of the methanolic extract of Justicia secunda Vahl leaves (Acanthaceae) were evaluated in Streptozotocin (STZ)-treated albino mice to confirm whether it could be considered an alternative candidate for the treatment of ...
Tomás Fregoso-Aguilar +11 more
doaj +1 more source
Injectable Peptide‐Based Functional Amyloid Hydrogels as Tunable Depots for Sustained Drug Delivery
Advanced Science, EarlyView.An injectable and tunable peptide‐based functional amyloid hydrogel provides sustained insulin release while preserving insulin stability and bioactivity. The hydrogel enables prolonged glycemic regulation in vivo, exhibits excellent biocompatibility, and shows no detectable IAPP and α‐Syn heterologous cross‐seeding, highlighting its potential as a ...
Ranjit Shaw +4 more
wiley +1 more source
Hypoglycemic Effect of Irradiation Se-enriched A.auricularia Polysaccharide on Type 1 Diabetes Mice
Shipin gongye ke-jiTo investigate different irradiation doses of Se-enriched A.Auricularia polysaccharide (SAAP) in type 1 diabetes mellitus (T1DM) mice. In this study, extraction of polysaccharides from selenium-enriched fungus was carried out after 60Co-γ-ray irradiation
Shuang LIU +4 more
doaj +1 more source
Plants, 2022 The genus Bauhinia s.l. (Leguminosae), known as cow’s hoof, unha de boi or pata de vaca, has been used in traditional medicine worldwide. The aim of the present review is to summarize the studies published on the biological activity of the main native ...
Renée Hersilia Fortunato +1 more
doaj +1 more source
, 2019 The current study aimed to evaluate the effect of methanolic extract of celery herb Apium graveolens in blood glucose level of the laboratory rats. 300mg/kg of plant extract was detected. The blood glucose level was measured after 3, 6 hrs.
Yarob Saad Abdil-Jaleel AL-kabi +1 more
core +1 more source
COX14 Variants Are Associated With Mitochondrial Complex IV Deficiency Nuclear Type 10 (MC4DN10)
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT COX14 encodes a transmembrane protein essential for cytochrome c oxidase (COX) complex assembly. A homozygous missense variant in COX14 was reported in three siblings from a single consanguineous family with severe, fatal infantile mitochondrial complex IV deficiency nuclear type 10 (MC4DN10; MIM# 619053).
Elias K. Awad +7 more
wiley +1 more source