Results 201 to 210 of about 922,924 (304)

Psychological Stress Promotes Tumor Growth in Hepatocellular Carcinoma Models Through Myeloid Signaling

Cancer Science, EarlyView.
Psychological stress promotes hepatocellular carcinoma progression through coordinated regulation of macrophages and neutrophils. Noradrenaline activates ADRB2 signaling in intratumoral macrophages, leading to CXCL2 production and neutrophil recruitment.
Keita Ogawa, Takahiro Aoki, Tatsuya Kaneko, Hongxuan Wang, Daiki Shimizu, Daisuke Katsumi, Iori Kojima, Hidekazu Tanaka, Kiwamu Motoyoshi, Ko Ozaki, Katsuhiro Nishimura, Tomohisa Iinuma, Mariko Takami, Shinichiro Motohashi   +13 more
wiley   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Assessment of hypothalamic-pituitary-adrenal axis impairment and effects of hydrocortisone treatment in adults with Prader-Willi syndrome. [PDF]

Front Endocrinol (Lausanne)
Góralska M, Pokrzywa A, Stańczyk A, Libura M, Bednarczuk T.   +4 more
europepmc   +1 more source

Multisystem developmental abnormalities and insulin resistance in ADTKD‐HNF1B with the p.E105K variant: A clinical conundrum

Diabetic Medicine, EarlyView.
Abstract Aims HNF1B variants cause autosomal dominant tubulointerstitial kidney disease (ADTKD‐HNF1B), but the phenotypic spectrum of variants of uncertain significance (VUS) remains incompletely defined. We aimed to characterise the multisystem phenotype associated with the HNF1B p.E105K variant and to examine the mechanism underlying insulin ...
YunZe Wang, KangChun Xu, PengFei Liu, Bin Wang, Yan Yang, ShanZhai Wei   +5 more
wiley   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Differential Neuroendocrine Responses and Dysregulation of the Hypothalamic-Pituitary-Adrenal Axis Following Repeated Mild Concussive Impacts and Blast Exposures in a Rat Model. [PDF]

Brain Sci
Samdavid Thanapaul RJR, Krishnan JKS, Govindarajulu MY, Pundkar CY, Phuyal G, Long JB, Arun P.   +6 more
europepmc   +1 more source

Updates on intra‐articular corticosteroid administration in horses

Equine Veterinary Education, EarlyView.
Summary Intra‐articular (IA) corticosteroid administration in equine athletes has gained increased attention recently, particularly in racing. Despite widespread corticosteroid use in equine practice for decades, there are still a lack of equine‐specific studies to address key questions related to their use.
K. Tanner, L. Bass, C. Kawcak, L. V. Schnabel, K. L. Hallowell, L. M. Pezzanite   +5 more
wiley   +1 more source

Analysis of the correlation between serum vitamin D and hypothalamic-pituitary-adrenal axis hormone levels in patients with post-traumatic stress disorder. [PDF]

Front Neurosci
Ge L, Xu W, Liu W, Cui P, Zhang L, Ju H.
europepmc   +1 more source

Exploring Our Hypothesis That Negative Stress Elicits Pain and Increases Neuromuscular Excitability via a Potentiated Startle Response

Acta Paediatrica, EarlyView.
Gösta Alfvén, Eva Andersson
wiley   +1 more source

Unraveling the upward intergenerational link between adolescent depression and maternal health in later life

Family Relations, EarlyView.
Abstract Objective This study investigated whether depressive symptoms in adolescence are associated with mother's physical health in later life. It further explored the potential mechanisms underlying this relationship, focusing on psychological, behavioral, and healthcare‐related pathways.
Keun Young Kwon, Hayun Jang, Jinho Kim
wiley   +1 more source