Results 81 to 90 of about 21,484 (235)

A hypothetic aging pathway from skin to hypothalamic suprachiasmatic nucleus via slow wave sleep

Sleep Science, 2016
Many observations have demonstrated that the hypothalamic neuroendocrine change determines the chronological sequence of aging in mammals. However, it remains uncertain on the mechanism to account for the hypothalamic aging manifestations.
Zi-Jian Cai
doaj   +1 more source

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Effect of hypothyroidism on the hypothalamic–pituitary–ovarian axis and reproductive function of pregnant rats

BMC Endocrine Disorders, 2018
Background This study aimed to detect changes in hormone levels in the hypothalamic–pituitary–ovarian axis in Sprague-Dawley (SD) rats with hypothyroidism, and identify differences in the pregnancy and abortion rates of female adult rats.
Jianran Sun, Cancan Hui, Tongjia Xia, Min Xu, Datong Deng, Faming Pan, Youmin Wang   +6 more
doaj   +1 more source

Colocalization of Dopamine D1 and D2 Receptors With Neuronal Nitric Oxide Synthase in the Rat Paraventricular Nucleus: A Structural Basis for Dopaminergic–Nitrergic Interaction

Anatomia, Histologia, Embryologia, Volume 55, Issue 4, July 2026.
ABSTRACT The paraventricular nucleus (PVN) plays a central role in neuroendocrine and autonomic regulation, including male sexual behaviour. Dopaminergic and nitrergic signalling within the PVN are functionally linked, but their cellular relationship remains unclear.
Aixa R. Bello, Manuel Mas, Ricardo Reyes
wiley   +1 more source

Distribution of Hypophysiotropic Thyrotropin-Releasing Hormone (TRH)-Synthesizing Neurons in the Hypothalamic Paraventricular Nucleus of the Mouse

The Journal of comparative neurology, 2010
Hypophysiotropic thyrotropin‐releasing hormone (TRH) neurons, the central regulators of the hypothalamic‐pituitary‐thyroid axis, are located in the hypothalamic paraventricular nucleus (PVN) in a partly overlapping distribution with non‐hypophysiotropic ...
A. Kádár, Edith Sánchez, G. Wittmann, P. Singru, T. Füzesi, A. Marsili, P. Larsen, Zsolt Liposits, R. Lechan, C. Fekete   +9 more
semanticscholar   +1 more source

Glucocorticoid Receptor Translational Isoforms Generate Unique Glucocorticoid Responses in the Mouse Brain

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
GR‐A knockin mice were generated that express the classic full‐length glucocorticoid receptor (GR‐A) but lack the highly conserved translational isoforms GR‐B, GR‐C1, GR‐C2, GR‐C3, GR‐D1, GR‐D2, and GR‐D3 that have progressively shorter N‐terminal transactivation domains (NTDs).
Robert H. Oakley, Tatsuya Sueyoshi, Sivapriya Ramamoorthy, Viktoriya D. Nikolova, David R. Goulding, Jianying Li, Manas K. Ray, Sheryl S. Moy, John A. Cidlowski   +8 more
wiley   +1 more source

Stress, stress systems, and Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Stress is increasingly recognized as an important, modifiable factor for Alzheimer's disease (AD), yet its roles in initiation, progression, and outcomes remain incompletely elucidated. Epidemiologic studies link chronic stress, early‐life adversity, and trauma to increased AD risk, while experimental models have uncovered mechanisms by which ...
Stephanie G. Eberly, Chayarndorn Phumsatitpong, Catherine E. Munro, Thomas C. Neylan, Daniela Kaufer, Alexander J. Ehrenberg   +5 more
wiley   +1 more source

Neuroendorine and epigentic mechanisms subserving autonomic imbalance and HPA dysfunction in the metabolic syndrome

Frontiers in Neuroscience, 2016
Impact of environmental stress upon pathophysiology of the metabolic syndrome (MetS) has been substantiated by epidemiological, psychophysiological, and endocrinological studies.
Erwin eLemche, Oleg S. Chaban, Alexandra V. Lemche   +2 more
doaj   +1 more source

Functional Segregation of Epileptogenicity within the Human Amygdala

Annals of Neurology, Volume 99, Issue 6, Page 1598-1612, June 2026.
Objective In temporal lobe epilepsy (TLE), the amygdala in the epileptogenic network is underestimated compared to other regions such as the hippocampus. Recent advances in anatomical neuroimaging and stereoelectroencephalography (SEEG) signal analyses could help better understand the involvement of the different amygdala nuclei in the genesis of ...
Odile Feys, Julia Makhalova, Samuel Medina Villalon, Maria Fratello, Hugo Dary, Stanislas Lagarde, Francesca Pizzo, Agnès Trébuchon, Maxime Guye, Jean‐Philippe Ranjeva, Romain Carron, Didier Scavarda, Christian‐George Bénar, Bernard Giusiano, Fabrice Bartolomei   +14 more
wiley   +1 more source