Results 111 to 120 of about 323,717 (308)

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Impact of Sleeve Gastrectomy on Body Weight and Food Intake Regulation in Diet-Induced Obese Mice

Current Issues in Molecular Biology
The epidemic of obesity has increased worldwide and is associated with comorbidities such as diabetes and cardiovascular disease. In this context, strategies that modulate body weight and improve glycemic metabolism have increased, and bariatric ...
Sandra Lucinei Balbo, Gabriela Moreira Soares, Joseane Morari, Antonio Machado Felisberto, Jean Franciesco Vettorazzi, Gabriela Alves Bronczek, Maria Lúcia Bonfleur, Everardo Magalhães Carneiro, Antonio Carlos Boschero, Lício Augusto Velloso   +9 more
doaj   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

Empagliflozin Attenuates High-Glucose-Induced Astrocyte Activation and Inflammation via NF-κB Pathway

Current Issues in Molecular Biology
Sodium-glucose cotransporter-2 (SGLT2) inhibitors regulate blood glucose levels in patients with type 2 diabetes mellitus and may also exert anti-inflammatory and anti-atherosclerotic effects by promoting M2 macrophage polarization.
Dong Hee Kim, Min Jin Lee, Dasol Kang, Ji Young Lee, Sujin Park, Ah Reum Khang, Ji Hyun Bae, Joo Yeon Kim, Su Hyun Kim, Yang Ho Kang, Dongwon Yi   +10 more
doaj   +1 more source

Correlations between Hypothalamus-Pituitary-Adrenal Axis Parameters Depend on Age and Learning Capacity [PDF]

, 2004
Onno C. Meijer, Bianca Topic, Peter J. Steenbergen, Gerhard Jocham, J.P. Huston, Melly S. Oitzl   +5 more
openalex   +1 more source

Reconstructing Coherent Functional Landscape From Multi‐Modal Multi‐Slice Spatial Transcriptomics by a Variational Spatial Gaussian Process

Advanced Science, EarlyView.
This study introduces stVGP, a variational spatial Gaussian process framework for multi‐modal, multi‐slice spatial transcriptomics. By integrating histological and genomic data through hybrid alignment and attention‐based fusion, stVGP reconstructs coherent 3D functional landscapes.
Zedong Wang, Bowen Fu, Chuanchao Zhang, Xiaoping Liu   +3 more
wiley   +1 more source

Characteristics of Patients with Craniopharyngioma and LongTerm Outcomes of Treatment

The Turkish Journal of Ear Nose and Throat
Objective: Craniopharyngioma (CP) is benign, but its treatment is challenging because of its occurrence in a critical area. Hypothalamic-pituitary dysfunction (HPD) is an important complication that is related to tumour itself or to therapy.
Hülya Hacişahinoğulları, Gamze Bilik Oyman, Duygu Dölen, Menekşe Bilge Bilgiç, Rasim Meral, Gülşah Yenidünya Yalın, Nurdan Gül, Ayşe Kubat Üzüm, Özlem Soyluk Selçukbiricik   +8 more
doaj   +1 more source

Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia [PDF]

, 2018
S. Nobis, A. Goichon, Najate Achamrah, Charlène Guérin, Saïda Azhar, Philippe Chan, Aline Morin, Christine Bôle‐Feysot, Jean Claude do Rego, David Vaudry, Pierre Déchelotte, Liliana Belmonte, Moı̈se Coëffier   +12 more
openalex   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

Could Insulin Be a Better Regulator of Appetite/Satiety Balance and Body Weight Maintenance in Response to Glucose Exposure Compared to Sucrose Substitutes? Unraveling Current Knowledge and Searching for More Appropriate Choices

Medical Sciences
Background: Insulin exerts a crucial impact on glucose control, cellular growing, function, and metabolism. It is partially modulated by nutrients, especially as a response to the intake of foods, including carbohydrates.
Georgios Antasouras, Antonios Dakanalis, Maria Chrysafi, Sousana K. Papadopoulou, Ioulia Trifonidi, Maria Spanoudaki, Olga Alexatou, Agathi Pritsa, Aikaterini Louka, Constantinos Giaginis   +9 more
doaj   +1 more source