Results 1 to 10 of about 92,945 (337)

Differential regulation of hypoxanthine and xanthine by obesity in a general population

Journal of Diabetes Investigation, 2020
Aims/Introduction Uric acid is synthesized by oxidation of hypoxanthine and xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a source of reactive oxygen species.
Masato Furuhashi, Masayuki Koyama, Yukimura Higashiura, Takayo Murase, Takashi Nakamura, Megumi Matsumoto, Akiko Sakai, Hirofumi Ohnishi, Marenao Tanaka, Shigeyuki Saitoh, Norihito Moniwa, Kazuaki Shimamoto, Tetsuji Miura   +12 more
doaj   +2 more sources

Surface-Enhanced Raman Analysis of Uric Acid and Hypoxanthine Analysis in Fractionated Bodily Fluids

Nanomaterials, 2023
In recent years, the disease burden of hyperuricemia has been increasing, especially in high-income countries and the economically developing world with a Western lifestyle. Abnormal levels of uric acid and hypoxanthine are associated with many diseases,
Furong Tian, Luis Felipe das Chagas e Silva de Carvalho, Alan Casey, Marcelo Saito Nogueira, Hugh J. Byrne   +4 more
doaj   +2 more sources

E. coli genetically modified for purine nucleobase release promotes butyrate generation and colonic wound healing during DSS insult [PDF]

Gut Microbes
The gut microbiota transforms energy stored as undigestible carbohydrates into a remarkable number of metabolites that fuel intestinal bacterial communities and the host tissue.
J. Scott Lee, Daniel J. Kao, Corey S. Worledge, Zachary F. Villamaria, Ruth X. Wang, Nichole M. Welch, Rachael E. Kostelecky, Sean P. Colgan   +7 more
doaj   +2 more sources

Hypoxanthine enhances the cured meat taste [PDF]

Animal Science Journal, 2016
AbstractWe evaluated the enhancement of cured meat taste during maturation by sensory analysis. We focused on the heat‐stable sarcoplasmic fraction (HSSF) to identify the factors related to cured meat taste. Because the dry matter of HSSF contained more than 30% nitrogen, nitrogen compounds such as free amino acids, small peptides and adenosine ...
Yukinobu Nakamura, Akihito Hattori, Yuka Yoshida, Sayaka Ichimura   +3 more
openaire   +3 more sources

Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

Malaria Journal, 2019
Background The malarial parasite Plasmodium falciparum is an auxotroph for purines, which are required for nucleic acid synthesis during the intra-erythrocytic developmental cycle (IDC) of the parasite.
Shivendra G. Tewari, Krithika Rajaram, Patric Schyman, Russell Swift, Jaques Reifman, Sean T. Prigge, Anders Wallqvist   +6 more
doaj   +2 more sources

The metabolic engineering of Escherichia coli for the high-yield production of hypoxanthine [PDF]

Microbial Cell Factories
Background Hypoxanthine, prevalent in animals and plants, is used in the production of food additives, nucleoside antiviral drugs, and disease diagnosis.
Siyu Zhao, Tangen Shi, Liangwen Li, Zhichao Chen, Changgeng Li, Zichen Yu, Pengjie Sun, Qingyang Xu   +7 more
doaj   +2 more sources

Brain network and energy imbalance in Parkinson’s disease: linking ATP reduction and α-synuclein pathology [PDF]

Frontiers in Molecular Neuroscience
Parkinson’s disease (PD) involves the disruption of brain energy homeostasis. This encompasses broad-impact factors such as mitochondrial dysfunction, impaired glycolysis, and other metabolic disturbances, like disruptions in the pentose phosphate ...
Hirohisa Watanabe, Sayuri Shima, Kazuya Kawabata, Yasuaki Mizutani, Akihiro Ueda, Akihiro Ueda, Mizuki Ito, Mizuki Ito   +7 more
doaj   +2 more sources

The Effect of Two Weeks of High-intensity Interval Training on Salvage nucleotide pathway [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2022
Purpose: The effects of exercise adaptation on improving the purine nucleotides components are inevitable, and physical activity improves the purine nucleotide salvage pathway.
Abbas Ghanbari Niaki, Rouhollah Haghshenas Gatabi   +1 more
doaj   +1 more source

Assessing Meat Freshness via Nanotechnology Biosensors: Is the World Prepared for Lightning-Fast Pace Methods?

Biosensors, 2023
In the rapidly evolving field of food science, nanotechnology-based biosensors are one of the most intriguing techniques for tracking meat freshness.
Wen Xia Ling Felicia, Kobun Rovina, Nasir Md Nur ‘Aqilah, Joseph Merillyn Vonnie, Koh Wee Yin, Nurul Huda   +5 more
doaj   +1 more source

Characterizing nanoplastics‐induced stress and its SERS fingerprint in an intestinal membrane model

Nano Select, 2021
Epithelium membranes provide important barrier functions, and it is important to understand how nanoparticle (NP) exposure affects their barrier function.
Qianyun Zhang, Björn M. Reinhard
doaj   +1 more source