Оцінювання мутагенної активності епоксидвмісних поліоксипропілентріолів у короткотривалих експериментах із використанням тканинних культур і бактерій [PDF]
, 2015 Introduction. Many chemicals polluting the environment can exert a specific impact on the body with significant general toxic effects, manifested not in the period of exposure and not immediately after it, but in remote periods in the life of individuals,
Кучерявенко, М.А.
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Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens [PDF]
, 2013 There is accumulating evidence that the nucleus accumbens (NAc) has an important role in the pathophysiology of depression. As the NAc is a key component in the neural circuitry of reward, it has been hypothesized that anhedonia, a core symptom of ...
A Dranovsky +32 more
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Signalling Mechanisms Underlying Doxorubicin and Nox2 NADPH Oxidase-Induced Cardiomyopathy: Involvement of Mitofusin-2 [PDF]
, 2017 BACKGROUND AND PURPOSE: The anthracycline doxorubicin (DOX), although successful as a first-line cancer treatment, induces cardiotoxicity linked with increased production of myocardial reactive oxygen species (ROS), with Nox2 NADPH oxidase-derived ...
Dunne, Philip D +7 more
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JIMD Reports, 2020 Background Lesch‐Nyhan disease (LND; OMIM 300322), caused by virtually absent hypoxanthine‐guanine phosphoribosyltransferase activity, in its classic form is characterised by hyperuricemia, variable cognitive impairment, severe motor disorder and a ...
Anna Bozano +6 more
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Selective degradation of abnormal proteins in mammalian tissue culture cells. [PDF]
, 1974 Journal ArticleThe degradation rates of several missense mutants of hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) in mouse L cells are compared to those of the wild-type enzyme.
Capecchi, Mario R. +1 more
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Efficient cDNA cloning by direct phenotypic correction of a mutant human cell line (HPRT-) using an Epstein-Barr virus derived cDNA expression vector. [PDF]
, 1991 Human cells are, in general, poor recipients of foreign DNA, which has severely hampered the cloning of genes by direct phenotypic correction of deficient human cell lines after DNA mediated gene transfer. In this communication a methodology is presented
Backendorf, C.M.P. (Claude) +5 more
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Molecular characterization of hypoxanthine guanine phosphoribosyltransferase mutant T cells in human blood: The concept of surrogate selection for immunologically relevant cells. [PDF]
Mutat Res Rev Mutat Res, 2022 Kaitz NA +5 more
europepmc +1 more source
Pharmacology and clinical drug candidates in redox medicine [PDF]
, 2015 SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I +11 more
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Whole Exome Sequencing Facilitates Early Diagnosis of Lesch–Nyhan Syndrome: A Case Series
DiagnosticsBackground: Lesch–Nyhan syndrome (LNS) is a rare X-linked recessive metabolic disorder caused by mutations in the HPRT1 gene, resulting in hypoxanthine–guanine phosphoribosyltransferase (HPRT) deficiency.
Hung-Hsiang Fang +9 more
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Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell [PDF]
, 2019 The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrheal disease and an important contributor to early-childhood mortality. Waterborne outbreaks occur frequently, even in countries with advanced water treatment capabilities,
Cuny, Gregory D. +7 more
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