Results 101 to 110 of about 17,899 (259)

IL‐1 receptor antagonist anakinra downregulates inflammatory cytokines during renal normothermic machine perfusion: Preliminary results

Artificial Organs, Volume 49, Issue 3, Page 451-459, March 2025.
Anakinra, an IL‐1 receptor antagonist, attenuated the inflammatory response during normothermic machine perfusion (NMP) in porcine kidneys subjected to mild ischemic insult. The preliminary study provides insight into the underlying mechanisms of renal injury and indicates NMP has potential as a platform for the targeted delivery of treatments to ...
Sarah A. Hosgood, Tom Moore, Alex Walker, Michael L. Nicholson   +3 more
wiley   +1 more source

Development, distribution and properties of purine phosphoribosyltransferases in mammals [PDF]

, 1973
The object of the work described in this thesis has been to determine the tissue distribution, development, and properties of the purine phosphoribosyltransferases (PRTases), especially in man but also in some other animals.A major part of the work was ...
Adams, Andrew
core   +1 more source

Small Duplication of HPRT 1 Gene May Be Causative For Lesh-Nyhan Disease in Iranian Patients [PDF]

, 2015
How to Cite This Article: Boroujerdi R, Shariati M, Naddafnia H, Rezaei H. Small Duplication of HPRT 1 Gene May Be Causative For Lesh-Nyhan Disease in Iranian Patients. Iran J Child Neurol.
BOROUJERDI, Razieh, NADDAFNIA, Hosein, REZAEI*, Hojatolah, SHARIATI, Mohsen   +3 more
core   +3 more sources

Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma

Cancer & Metabolism
Background Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver mutation on histone H3 converting lysine 27 to methionine (H3K27M).
Erik R. Peterson, Peter Sajjakulnukit, Andrew J. Scott, Caleb Heaslip, Anthony Andren, Kari Wilder-Romans, Weihua Zhou, Sravya Palavalasa, Navyateja Korimerla, Angelica Lin, Alexandra O’Brien, Ayesha Kothari, Zitong Zhao, Li Zhang, Meredith A. Morgan, Sriram Venneti, Carl Koschmann, Nada Jabado, Costas A. Lyssiotis, Maria G. Castro, Daniel R. Wahl   +20 more
doaj   +1 more source

Data supporting the design and evaluation of a universal primer pair for pseudogene-free amplification of HPRT1 in real-time PCR

Data in Brief, 2015
Hypoxanthine-guanine phosphoribosyltransferase 1 (HPRT1) is a common housekeeping gene for sample normalization in the quantitative reverse transcriptase polymerase chain (qRT-PCR).
Reza Valadan, Akbar Hedayatizadeh-Omran, Mahdyieh Naghavi Alhosseini-Abyazani, Omolbanin Amjadi, Alireza Rafiei, Mohsen Tehrani, Reza Alizadeh-Navaei   +6 more
doaj   +1 more source

Age‐dependent reduction in voltage‐gated inward sodium current and Scn8a gene expression in murine stellate ganglia

Annals of the New York Academy of Sciences, Volume 1545, Issue 1, Page 91-104, March 2025.
An investigation into the electrophysiological properties of murine ventricular myocardium and stellate ganglia was conducted using the loose patch clamp technique at two distinct age points to assess aging‐mediated alterations in ionic currents. The voltage‐gated inward sodium current, quantified as maximum sodium current (INa(Max)), was reduced with ...
Bonn Lee, Shiraz Ahmad, Charlotte E. Edling, Christopher L.‐H. Huang, Fiona E. N. LeBeau, Kamalan Jeevaratnam   +5 more
wiley   +1 more source

Metabolomic profiling of the synergistic effects of melittin in combination with cisplatin on ovarian cancer cells [PDF]

, 2017
Melittin, the main peptide present in bee venom, has been proposed as having potential for anticancer therapy; the addition of melittin to cisplatin, a first line treatment for ovarian cancer, may increase the therapeutic response in cancer treatment via
Alonezi, Sanad, Clements, Carol J., Dufton, Mark J., Ferro, Valerie A., Jeon, Jong-Woon, Park, Jin-Kyu, Parkinson, John A., Tusiimire, Jonans, Wallace, Jennifer, Watson, David G., Young, Louise C.   +10 more
core   +1 more source

Targeted Nucleotide Substitution in Mammalian Cell by Target-AID

Bio-Protocol, 2017
Programmable RNA-guided nucleases based on CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated protein) systems have been applied to various type of cells as powerful genome editing tools. By using activation-induced
Takayuki Arazoe, Keiji Nishida, Akihiko Kondo   +2 more
doaj   +1 more source

ECSIT‐X4 is Required for Preventing Pressure Overload‐Induced Cardiac Hypertrophy via Regulating Mitochondrial STAT3

Advanced Science, Volume 12, Issue 8, February 24, 2025.
ECSIT‐X4 is the predominant cardiac isoform of ECSIT, encoded by the Ecsit‐X4 transcript variant in adult cardiomyocytes. The splicing junction of exon 9 generates the mouse Ecsit‐X4 isoform, resulting in a recognizable C‐terminal sequence. It is shown that ECSIT‐X4 interacts with STAT3, enhancing the activity of complex I, thereby promoting ...
Xia Lu, Tingting Tong, Haoliang Sun, Yi Chen, Yongfeng Shao, Pengxi Shi, Linli Que, Li Liu, Guoqing Zhu, Qi Chen, Chuanfu Li, Jiantao Li, Shuo Yang, Yuehua Li   +13 more
wiley   +1 more source

New biomarkers for early diagnosis of Lesch-Nyhan disease revealed by metabolic analysis on a large cohort of patients [PDF]

, 2015
International audienceBackground: Lesch-Nyhan disease is a rare X-linked neurodevelopemental metabolic disorder caused by a wide variety of mutations in the HPRT1 gene leading to a deficiency of the purine recycling enzyme hypoxanthine-guanine ...
Brassier, Anaïs, Cahu, Julie, Ceballos-Picot, Irène, Daignan-Fornier, Bertrand, Ea, Hang-Korng, Jais, Jean-Philippe, Le dantec, Aurélia, Ledroit, Morgan, Pinson, Benoit   +8 more
core   +2 more sources