Results 71 to 80 of about 14,819 (239)

In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis. [PDF]

, 2016
UnlabelledToxoplasma gondii is an obligate intracellular parasite that invades host cells and replicates within a unique parasitophorous vacuole. To maintain this intracellular niche, the parasite secretes an array of dense granule proteins (GRAs) into ...
Bell, Hannah N, Bradley, Peter J, Coppens, Isabelle, Kim, Elliot W, Lin, Andrew H, Nadipuram, Santhosh M, Vashisht, Ajay A, Wohlschlegel, James A   +7 more
core   +2 more sources

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

Mitigating Dexamethasone‐Induced Muscle Wasting and Mitochondrial Impairment in Mice on a High‐Fat and High‐Sucrose Diet With Peanut Sprout Extract

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Peanut sprout extract (PSE) significantly attenuated skeletal muscle atrophy induced by a high‐fat, high‐sucrose diet and dexamethasone, improving muscle strength and reducing triglyceride accumulation and inflammation. It enhanced mitochondrial function by upregulating TFAM and OXPHOS proteins and partially restoring PGC1α expression.
Sang‐Mi Jo, Thi My Tien Truong, Hyun‐Jin Jang, Ji Hee Lim, Inhae Kang   +4 more
wiley   +1 more source

Metabolic constraint of human telomere length by nucleotide salvage efficiency

Nature Communications
Human telomere length is tightly regulated and associated with diseases at either extreme, but how these bounds are established remains incompletely understood.
William Mannherz, Andrew Crompton, Noah Lampl, Suneet Agarwal   +3 more
doaj   +1 more source

Epiafzelechin, a Flavanol, Regulates Lipid Homeostasis Through Modulation of HMGCR, PCSK9, and PPAR‐α: Mechanistic Insights and Therapeutic Implications

Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.
Hyperlipidemia remains a leading modifiable risk factor for cardiovascular morbidity and mortality. Statins are considered the cornerstone of treatment; however, their adverse effects and limited efficacy in certain patient populations necessitate exploration of novel therapeutic avenues. Epiafzelechin (EZN), a flavanol with established antioxidant and
Saud O. Alshammari, Nazifa Shahzad, Muhammad Nasir Hayat Malik, Qamar A. Alshammari, Abdulkarim Alshammari, Bassam S. M. Al Kazman, Muhammad Atif, Gideon F. B. Solre, Vivek Pandey   +8 more
wiley   +1 more source

5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications [PDF]

, 2013
Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are unevenly distributed in the brain, suggesting that nucleosides have region ...
Dobolyi, Árpád, Juhász, Gábor, Kovács, Zsolt, Kékesi, Katalin A.   +3 more
core  

The role of aging on endothelial cell–cell junctions and pulmonary microvascular permeability in male mice

Physiological Reports, Volume 13, Issue 24, December 2025.
Aging contributes to impairments in pulmonary microvascular endothelial cell‐cell junctions and barrier function, leading to an increased predisposition to injury. Created in BioRender. Gill, S. (2025) https://BioRender.com/l14r5v8 Abstract Pulmonary microvascular endothelial cell (PMVEC) intercellular junctions are critical for maintaining barrier ...
Aminmohamed Manji, Lefeng Wang, Cynthia Pape, Sanjay Mehta, Preya Patel, Samuel‐Caleb Yeung, Eric K. Patterson, Antoine Dufour, Daniel Young, Ruud A. W. Veldhuizen, Sean E. Gill   +10 more
wiley   +1 more source

Oligomeric state of hypoxanthine−guanine phosphoribosyltransferase from Mycobacterium tuberculosis [PDF]

Biochimie, 2017
Sedimentation equilibrium and size-exclusion chromatography experiments on Mycobacterium tuberculosis hypoxanthine-guanine phosphoribosyltransferase (MtHGPRT) have established the existence of this enzyme as a reversibly associating mixture of dimeric and tetrameric species in 0.1 M Tris-HCl-0.012 M MgCl2, pH 7.4.
Wai Soon Eng, Dianne T. Keough, Dana Hockova, Donald J. Winzor, Luke W. Guddat   +4 more
openaire   +3 more sources

Expand+Functional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors [PDF]

, 2010
Despite the critical role of pre-mRNA splicing in generating proteomic diversity and regulating gene expression, the sequence composition and function of intronic splicing regulatory elements (ISREs) have not been well elucidated.
Berglund, J. Andrew, Culler, Stephanie J., Hoff, Kevin G., Smolke, Christina D., Voelker, Rodger B.   +4 more
core   +4 more sources

Inter‐Caste Comparison Reveals a Unique Bioenergetic Signature in Long‐Lived Ant Queens

Molecular Ecology, Volume 34, Issue 21, November 2025.
ABSTRACT Within the same species of eusocial insects, individuals of different castes typically display widely different life‐history traits: sterile workers live for a few months, while queens can live for decades. Ageing theories emphasise the importance of metabolism and oxidative stress in explaining longevity, with mitochondrial bioenergetics ...
Maïly Kervella, Fabrice Bertile, Alexandra Granger‐Farbos, Benoît Pinson, Claire Villette, Dimitri Heintz, Alain Schmitt, Martin Quque, Frédéric Bouillaud, François Criscuolo   +9 more
wiley   +1 more source