Results 101 to 110 of about 85,586 (228)

Mouse versus Rat: Profound Differences in Meiotic Regulation at the Level of the Isolated Oocyte [PDF]

, 2011
Cumulus cell-enclosed oocytes (CEO), denuded oocytes (DO), or dissected follicles were obtained 44–48 hr after priming immature mice (20–23 days old) with 5 IU or immature rats (25–27 days old) with 12.5 IU of equine chorionic gonadotropin, and exposed ...
Biggers, Brannstrom, Chen, Chen, Cho, Dekel, Dekel, Dekel, Dekel, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Eppig, Fagbohun, Fagbohun, Han, Hubbard, LaRosa, LaRosa, Larsen, Magnusson, Makris, Masciarelli, Mouse Genome Sequencing Consortium, Mullins, Norris, Norris, Norris, Racowsky, Rat Genome Sequencing Project Consortium, Ratner, Ratner, Reizel, Richard, Romero, Schultz, Sela-Abramovich, Sela-Abramovich, Sela-Abramovich, Shitsukawa, Tornell, Tornell, Tornell, Tornell, Tornell, Tsafriri, Tsafriri, Vaccari, Vivarelli, Zeilmaker, Zhang, Zhang, Zhang, Zhao   +61 more
core   +2 more sources

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects

Endocrine Journal
Blood levels of hypoxanthine (HX) have been suggested as potential biomarkers associated with intramuscular metabolic dynamics in response to exercise.
Tomoyuki Hara, Yuya Fujishima, Hitoshi Nishizawa, Yusuke Kawachi, Takashi Nakamura, Seigo Akari, Yoshiyuki Ono, Hirotaka Watanabe, Taka-aki Sakaue, Yoshinari Obata, Hirofumi Nagao, Shiro Fukuda, Takashi Kanamoto, Mitsuyoshi Takahara, Naoto Katakami, Ken Nakata, Iichiro Shimomura   +16 more
doaj   +1 more source

Human hypoxanthine-guanine phosphoribosyltransferase.

Journal of Biological Chemistry, 1983
A mutant form of human hypoxanthine-guanine phosphoribosyltransferase (HPRTToronto) was isolated from erythrocytes of a male patient with gout due to a partial deficiency of enzyme activity. The tryptic peptides of HPRTToronto were mapped by reverse-phase high pressure liquid chromatography in an attempt to define the precise abnormality in its primary
J M, Wilson, R, Kobayashi, I H, Fox, W N, Kelley   +3 more
openaire   +2 more sources

Fetal glucose availability: a key regulator of the metabolic, hormonal and contractility profiles of the fetal sheep heart

The Journal of Physiology, EarlyView.
Abstract figure legend To investigate the role of glucose availability in fetal left ventricle (LV) development, this study assessed whether maternal late gestation undernutrition (LGUN; 50% of Control diet) induced alterations in the contractility, metabolic, and hormonal profile can be ameliorated in LGUN fetuses receiving glucose infusion (LGUN+G ...
Melanie R. Bertossa, Jack R. T. Darby, Stacey L. Holman, Steven K. S. Cho, Ashley S. Meakin, Mitchell C. Lock, Jordan A. Minns, Michael D. Wiese, Christopher K. Macgowan, Mike Seed, Janna L. Morrison   +10 more
wiley   +1 more source

Strong, specific, monodentate G-C base pair recognition by N7-inosine derivatives in the pyrimidine•purine-pyrimidine triple-helical binding motif [PDF]

, 2017
The nucleoside analogs 7-(2′-deoxy-α-D-ribofuranosyl)hypoxanthine (β7H, 1), 7-(2′-deoxy-β-D-ribofuranosyl)hypoxanthine (β7H, 2) and 7-(2′-O-methyl-β-Dribofuranosyl)hypoxanthine (β7HOMe, 3) were prepared and incorporated into triplex forming ...
Leumann, Christian J., Marfurt, Judith, Parel, Serge P.   +2 more
core  

Brain network and energy imbalance in Parkinson’s disease: linking ATP reduction and α-synuclein pathology

Frontiers in Molecular Neuroscience
Parkinson’s disease (PD) involves the disruption of brain energy homeostasis. This encompasses broad-impact factors such as mitochondrial dysfunction, impaired glycolysis, and other metabolic disturbances, like disruptions in the pentose phosphate ...
Hirohisa Watanabe, Sayuri Shima, Kazuya Kawabata, Yasuaki Mizutani, Akihiro Ueda, Akihiro Ueda, Mizuki Ito, Mizuki Ito   +7 more
doaj   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Simultaneous Electrochemical Determination of Uric Acid, Xanthine, and Hypoxanthine Using AgNPs/MIL-101(Cr) Modified Electrode

ECS Sensors Plus
This paper presents silver nanoparticles supported by the Matérial Institute Lavoisier-101 (AgNPs/MIL-101(Cr)) for electrochemical determination of uric acid (URA), xanthine (XAT), and hypoxanthine (HPX).
Nguyen Quang Man, Nguyen Ngoc Nghia, Vo Thi Khanh Ly, Nguyen Duc Vu Quyen, Le Thi Hoa, Ho Van Minh Hai, Le Van Thanh Son, Le Thi Hong Phong, Nguyen Dinh Luyen, Nguyen Chi Bao, Dinh Quang Khieu   +10 more
doaj   +1 more source

Model‐Based Strategy for 6‐Mercaptopurine Treatment in Acute Lymphoblastic Leukemia Maintenance Phase: Prediction of 6‐TGN and 6‐MMP Concentrations to Optimize Treatment

Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.
ABSTRACT Introduction Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The pro‐drug 6‐mercaptopurine (6‐MP), essential during maintenance, is converted into active 6‐thioguanine (6‐TGN) and toxic 6‐methylmercaptopurine (6‐MMP) metabolites, resulting in marked variability in efficacy and toxicity.
Anne Ravix, Anaïs Maillat, Eva Choong, Chantal Csajka, Monia Guidi, Francesco Ceppi   +5 more
wiley   +1 more source