Results 101 to 110 of about 56,727 (193)
Yeast GMP Kinase Mutants Constitutively Express AMP Biosynthesis Genes by Phenocopying a Hypoxanthine-Guanine Phosphoribosyltransferase Defect [PDF]
, 2000 Karine Lecoq +2 more
openalex +1 more source
Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging
Aging Cell, Volume 25, Issue 1, January 2026.Untargeted metabolomics reveals a unique cord plasma metabolic landscape versus adult. Age‐declining cord‐specific enriched metabolites are identified as antiaging candidates, with a 5‐compound formula validated in proof‐of‐experiments to extend lifespan and healthspan in human cells and C. elegans.
JiaYu Liu +27 more
wiley +1 more source
Human hypoxanthine-guanine phosphoribosyltransferase.
, 1983 James M. Wilson +3 more
openalex +1 more source
Early‐Life Climbing Stratifies the Metabolome and Mortality Risk in Genetically Identical Flies
Aging Cell, Volume 25, Issue 1, January 2026.Isogenic Drosophila melanogaster vary greatly in longevity. Fractionation of an isogenic cohort based on climbing behavior early in life stratifies variation in the metabolome, longevity and mortality risk offering a tractable system to study intrinsic sources of variation in aging.
Benjamin R. Harrison +6 more
wiley +1 more source
Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas [PDF]
, 2023 Jianxing Yin +19 more
openalex +1 more source
Veterinary Ophthalmology, Volume 29, Issue 1, January 2026.ABSTRACT Objective We hypothesized that canine corneal epithelial cells maintain their proliferative properties through autocrine secretion of growth‐promoting factors. This study aimed to investigate the maintenance mechanism of the proliferative properties of canine corneal epithelial cells by comparing the autocrine secretion of soluble factors in ...
Maresuke Morita +6 more
wiley +1 more source
Regulation of hypoxanthine metabolism in Streptomyces cyanogenus.
, 1984 Tatsuhiko Ohe, Yasuto Watanabe
openalex +2 more sources
Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.Hyperlipidemia remains a leading modifiable risk factor for cardiovascular morbidity and mortality. Statins are considered the cornerstone of treatment; however, their adverse effects and limited efficacy in certain patient populations necessitate exploration of novel therapeutic avenues. Epiafzelechin (EZN), a flavanol with established antioxidant and
Saud O. Alshammari +8 more
wiley +1 more source
Substrate inhibition in a human variant of hypoxanthine-guanine phosphoribosyltransferase.
, 1984 Lafras M. Steyn, Eric H. Harley
openalex +1 more source