Results 101 to 110 of about 103,245 (286)

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function [PDF]

, 2014
Xanthine oxidase (XOD) is an enzyme which plays a central role in purine catabolism by converting hypoxanthine into xanthine and then further into uric acid.
Abooali, Maryam, Coughlan, Karen, Gibbs, Bernhard F., Lall, Gurprit S., Lall, Harjinder S., Sumbayev, Vadim V.   +5 more
core   +1 more source

A Comprehensive Review of Probiotics in Alleviating Hyperuricemia: Mechanisms, Strain Engineering, and Food Applications

Food Bioengineering, EarlyView.
Screening and modification of probiotics that can efficiently reduce uric acid provide a new strategy for food‐grade hyperuricemia intervention. ABSTRACT Hyperuricemia has become one of the most prevalent global epidemics, significantly impacting both the economy and the health of individuals.
Le Wang, Qi Wu, Mengjia Zhang, Zifu Ni, Pengshuai Zhang, Siyuan Bai, Yibin Wang, Zhongke Sun   +7 more
wiley   +1 more source

Influence of physical, chemical and inducer treatments on menaquinone-7 biosynthesis by Bacillus subtilis MTCC 2756 [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2015
Effects of physical and chemical treatment on nutrient mobility, their utilization for menaquinone-7 (MK-7) biosynthesis; growth of microbial cells has been investigated in the present research. Bacillus subtilis MTCC 2756 fermented medium was supplied
Alka Puri, Murteza Iqubal, Rasheeduz Zafar, Bibhu Prasad Panda   +3 more
doaj  

Rapid, Diagnostic Test for Cardiac Ischemia [PDF]

, 2017
Current methods to detect cardiac ischemia rely on biomarkers such as troponin. Elevated levels of troponin are observed hours after the cardiac event.
Contreras, Julio, Gonzales, Jose, Nasreldeen, Abdelmagid, Physioc, Emerson, Thoresen, Evan   +4 more
core   +2 more sources

Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin I2 analogue, OP-41483 [PDF]

, 1998
Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects.
Ishizaki, N, Jin, MB, Kawashima, Y, Shimamura, T, Starzl, TE, Todo, S, Totsuka, E, Urakami, A, Zhu, Y   +8 more
core   +1 more source

Unraveling the benefits of Bacillus subtilis DSM 29784 poultry probiotic through its secreted metabolites: an in vitro approach

Microbiology Spectrum
The probiotic Bacillus subtilis 29784 (Bs29784) sustains chicken’s intestinal health, enhancing animal resilience and performance through the production of the bioactive metabolites hypoxanthine (HPX), niacin (NIA), and pantothenate (PTH).
Nuria Vieco-Saiz, Damien P. Prévéraud, Eric Pinloche, Aurélien Morat, Pauline Govindin, Hervé M. Blottière, Elliot Matthieu, Estelle Devillard, Jessika Consuegra   +8 more
doaj   +1 more source

Minimizing quantification uncertainty in nanoplasmonic platforms: Multifunctional MoS2‐integration for precise biomarker determination

InfoMat, EarlyView.
The multifunctional integration of MoS2 into the SERS platform addresses key limitations in accurate quantification. Atomically thin MoS2 reduces spot‐to‐spot variations via plasmonic calibration and improves quantification reliability by ensuring consistent signal changes with analyte concentration.
Seungkyun Lee, Seongdae Kwon, Seunghee H. Cho, Minjae Ku, Young Woo Han, Gunwoo Jo, Jeongwon Park, Hanhwi Jang, Kibum Kang, Yeon Sik Jung   +9 more
wiley   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source