Results 121 to 130 of about 85,586 (228)

Achilles tenocytes from diabetic and non diabetic donors exposed to hyperglycemia respond differentially to inflammatory stimuli and stretch

Journal of Anatomy, Volume 248, Issue 4, Page 675-688, April 2026.
Scheme depicting the experimental set up of the study. Achilles tendons and tenocytes were isolated from heterozygous (fa/+, non diabetic: non DMT2) and homozygous (fa/fa, diabetic: DMT2) Zucker Diabetic Fatty (ZDF) rats. Tendon degeneration, collagen type 1 alpha 1 chain (COL1A1) and alpha smooth muscle actin (αSMA) expression was determined in rat ...
Nils Fleischmann, Sarah Hofmann, Clemens Gögele, Eva Frank, Christian Werner, Maria Kokozidou, Bernd Hoffmann, Jens Konrad, Gundula Schulze‐Tanzil   +8 more
wiley   +1 more source

Narrative review of strategies for blood product shelf‐life extension

Transfusion, EarlyView.
Mike Akaraphanth, Jessica Oudakker, Matthew Paulson, Michael Adam Meledeo, Kristin M. Reddoch‐Cardenas, Lusha Xiang, Steven G. Schauer, Todd Getz   +7 more
wiley   +1 more source

Protective Effect of Protaetia brevitarsis Larvae Extract on Alcoholic Liver Disease in Mice

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
This study evaluated the hepatoprotective effects of Protaetia brevitarsis larvae water extract (PBLE) in a chronic‐plus‐binge ethanol mouse model. PBLE attenuated hepatic lipid accumulation and liver injury by modulating alcohol metabolism‐related enzymes and reducing oxidative stress and inflammation.
Sueun Lee, Young Hye Seo, Yun‐Soo Seo, Hyeon‐Hwa Nam, Jun Lee, Joong‐Sun Kim, Ji Hye Lee   +6 more
wiley   +1 more source

Mechanisms of base selection by the E.coli mispaired uracil glycosylase [PDF]

, 2008
The repair of the multitude of single-base lesions formed daily in the cells of all living organisms is accomplished primarily by the base-excision repair (BER) pathway that initiates repair through a series of lesion-selective glycosylases.
Darwanto, Agus, Goddard, William, III, Liu, Pingfang, Pascal, Tod, Sowers, Lawrence C., Theruvathu, Jacob A., Valinluck Lao, Victoria   +6 more
core   +2 more sources

Minimizing quantification uncertainty in nanoplasmonic platforms: Multifunctional MoS2‐integration for precise biomarker determination

InfoMat, Volume 8, Issue 3, March 2026.
The multifunctional integration of MoS2 into the SERS platform addresses key limitations in accurate quantification. Atomically thin MoS2 reduces spot‐to‐spot variations via plasmonic calibration and improves quantification reliability by ensuring consistent signal changes with analyte concentration.
Seungkyun Lee, Seongdae Kwon, Seunghee H. Cho, Minjae Ku, Young Woo Han, Gunwoo Jo, Jeongwon Park, Hanhwi Jang, Kibum Kang, Yeon Sik Jung   +9 more
wiley   +1 more source

Retinal Capillary Density Reduction Contributes to Dysthyroid Optic Neuropathy via an L‐Arginine‐NO Pathway: A Metabonomics and Clinical Trial Study

MedComm, Volume 7, Issue 3, March 2026.
Oxidative stress induces endothelial nitric oxide synthase (eNOS) uncoupling and L‐arginine depletion, reducing nitric oxide (NO) bioavailability in vascular endothelium and contributing to decreased retinal capillary density (RCD) in dysthyroid optic neuropathy (DON).
Yunhai Tu, Congcong Yan, Lu Chen, Weijie Liu, Xiaozhou Hu, Mengyuan Gao, Wei Rao, Jiayi Zhang, Junye Zhu, Hui Wu, Kang Zhang, Meng Zhou, Wencan Wu   +12 more
wiley   +1 more source

Phosphoproteomic Reveals That Phosphoglycerate Kinase 2 Suppresses Hypoxanthine Accumulation in Broiler

Food Frontiers
Recent studies have found that the amount and proportion of meat flavor–related metabolites differ among different parts of muscle, which is partly attributed to their diverse myofiber type composition.
Manting Ma, Xin Yang, Shaofen Kong, Rongshuai Yuan, Zhen Zhou, Qinghua Nie, Bolin Cai   +6 more
doaj   +1 more source

Trans‐Omics Integration Reveals That the Kidney Contributes to Systemic Aging via Sexually Dimorphic Accumulation of Glycosphingolipids

MedComm, Volume 7, Issue 3, March 2026.
Female‐specific renal GluCer accumulation disrupts mitochondrial quality control via a conserved purine‐mTORC1 pathway, triggering a wave of uremic toxins into the systemic circulation that constitutes a female‐biased vulnerability toward renal‐driven multiorgan senescence.
Zhen Ni, Chenyin Cao, Yanlin Tian, Jinming Mu, He Tian, Zehua Wang, Shaohua Zhang, Mingjun Cao, Yuntian Yang, Wei Ling Florence Lim, Jingkang Cui, Huan Sun, Huan Miao, Yuan Wang, Jie Du, Timothy Kwok, Huan Chen, Sin Man Lam, Guanghou Shui   +18 more
wiley   +1 more source

Physiologically Based Pharmacokinetic Virtual Twin Approach for Fludarabine Dosing in Pediatric Hematopoietic Stem Cell Transplantation

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Fludarabine (Flu), administered as a prodrug Flu monophosphate, is a lymphodepleting agent used prior to hematopoietic stem cell transplantation (HSCT) which exhibits substantial pharmacokinetics (PK) variability, contributing to suboptimal outcomes.
Mourad Mseddi, Christa Nath, Khalil Ben Hassine, Vid Mlakar, Yvonne Gloor, Fanny Gonzales, Chakradhara Rao S. Uppugunduri, Youssef Daali, Steven Keogh, Marc Ansari   +9 more
wiley   +1 more source

THE ESTIMATION OF HYPOXANTHINE

Journal of Biological Chemistry, 1942
In a previous paper there was described a procedure for the isolation of the purines in a form suitable for the quantitative determination of the individual substances (1). A later publication reported a method for the separation of adenine and hypoxanthine and the determination of the adenine by precipitation of adenine picrate and titration of the ...
openaire   +1 more source