Results 61 to 70 of about 103,245 (286)

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, EarlyView.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

Detection of Hypoxanthine from Inosine and Unusual Hydrolysis of Immunosuppressive Drug Azathioprine through the Formation of a Diruthenium(III) System

Biosensors, 2021
Hypoxanthine (hpx) is an important molecule for both biochemistry research and biomedical applications. It is involved in several biological processes associated to energy and purine metabolism and has been proposed as a biomarker for a variety of ...
Marta Orts-Arroyo, Isabel Castro, José Martínez-Lillo   +2 more
doaj   +1 more source

Cardiomyocyte-Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Sirtuin 5 (SIRT5), a mitochondrial NAD+‐dependent deacylase, regulates fundamental cellular pathways, including energy substrate metabolism. The current study is designed to better elucidate the role of SIRT5 in the development of heart failure (HF). Methods Mice with cardiomyocyte‐specific deletion (cSirt5−/−) or overexpression (cSirt5‐Tg)
Byrne NJ, Koentges C, Pfeil K, Lueg JC, Bakshi S, Tarkhnishvili A, Vosko I, Gollmer J, Birkle LC, Rathner T, Birkle S, Tang S, Rau C, Hoffmann MM, Odening KE, Barnes S, Wilson LS, Ljubojevic-Holzer S, Wallner M, von Lewinski D, Rainer P, Sedej S, Sourij H, Bode C, Wende AR, Zirlik A, Bugger H.   +26 more
europepmc   +2 more sources

Myocardial release of hypoxanthine and lactate during percutaneous transluminal coronary angioplasty [PDF]

, 1989
The response of myocardial lactate and hypoxanthine metabolism during percutaneous transluminal coronary angioplasty was studied in a series of 15 patients undergoing this procedure.
Brand, M.J.B.M. (Marcel) van den, Feyter, P.J. (Pim) de, Harmsen, E., Hugenholtz, P.G. (Paul), Jong, J.W. (Jan Willem) de, Piscione, F., Serruys, P.W.J.C. (Patrick), Suryapranata, H. (Harry)   +7 more
core   +1 more source

Cellular Hallmarks From Volume Electron Microscopy Reveal Developmental Progression of Plasmodium Ookinetes

Advanced Science, EarlyView.
This article presents a detailed ultrastructural cell atlas of Plasmodium ookinete development using advanced volume electron microscopy (v) techniques. It defines seven distinct developmental stages, revealing complex organelle interactions and offering new insights into parasite differentiation.
Nedal Darif, Marco Rheinnecker, Kolja Hildenbrand, Thanat Chookajorn, Lilian P. Dorner, Jean‐Karim Hériché, Sara Henriksson, Charlotta Funaya, Franziska Hentzschel, Linda Sandblad, Oliver Billker, Yannick Schwab, Friedrich Frischknecht   +12 more
wiley   +1 more source

Evaluation of the Uricogenic Effect of Hypoxanthine and the Hypoxanthine‐Lowering Process of Shrimp (Metapenaeus ensis)

Food Frontiers
One of the main reasons for hyperuricemia is high purine intake and restricting the intake of high purine food is the main management for avoiding hyperuricemia.
Wanqian Sha, Lu xiao, Chunlin Tao, Chuanli Hou, Yanbo Wang, Huilin Liu, Jiaoyan Ren   +6 more
doaj   +1 more source

Surface-enhanced Raman spectroscopy for the forensic analysis of vaginal fluid [PDF]

, 2016
Vaginal fluid is most often found at crime scenes where a sexual assault has taken place or on clothing or other items collected from sexual assault victims or perpetrators.
Zegarelli, Kathryn Anne
core   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

Absolute quantification of the host-to-parasite DNA ratio in Theileria parva-infected lymphocyte cell lines [PDF]

, 2016
Theileria parva is a tick-transmitted intracellular apicomplexan pathogen of cattle in sub-Saharan Africa that causes East Coast fever (ECF). ECF is an acute fatal disease that kills over one million cattle annually, imposing a tremendous burden on ...
Bishop, Richard P., Daubenberger, Claudia A., Gotia, Hanzel T., Knowles, Donald P., Munro, James B., Silva, Joana C.   +5 more
core   +4 more sources

Plasma level of hypoxanthine/xanthine as markers of oxidative stress with different stages of obstructive sleep apnea syndrome

Annals of Saudi Medicine, 2014
BACKGROUND AND OBJECTIVES Tissue hypoxia due to repeated apneas among patients of obstructive sleep apnea syndrome (OSAS) leads to cumulative oxidative stress.
H. Hira, P. Samal, A. Kaur, S. Kapoor
semanticscholar   +1 more source