Results 81 to 90 of about 9,789 (207)
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 2, August 2025.Metabolic syndrome (MetS) is a combination of several factors, which lead to a higher risk of cardiovascular and other diseases. To study MetS, its mechanisms and means to alleviate complications associated with it, there is a demand for suitable animal models and their strains.
Jan Soukop +9 more
wiley +1 more source
British Journal of Pharmacology, Volume 182, Issue 16, Page 3744-3766, August 2025.Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens +15 more
wiley +1 more source
Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection [PDF]
, 2016 Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic, and degenerative diseases in humans.
Gurung, Prajwal +9 more
core +1 more source
Efficient gene targeting by homologous recombination in rat embryonic stem cells.
PLoS ONE, 2010 The rat is the preferred experimental animal in many biological studies. With the recent derivation of authentic rat embryonic stem (ES) cells it is now feasible to apply state-of-the art genetic engineering in this species using homologous recombination.
Stephen Meek +6 more
doaj +1 more source
British Journal of Pharmacology, Volume 182, Issue 16, Page 3903-3922, August 2025.Abstract Background and Purpose Immune checkpoint inhibitors, such as antiPD1, revolutionized melanoma treatment. However, resistance and low response rates remain problems. Our goal was to pinpoint actionable biomarkers of resistance to anti‐PD1 treatment and verify therapeutic effectiveness in vivo.
Szonja Anna Kovács +13 more
wiley +1 more source
Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension [PDF]
, 2012 BACKGROUND: Beyond their role as innate immune effectors, natural killer (NK) cells are emerging as important regulators of angiogenesis and vascular remodeling.
Campbell, Kate +17 more
core +1 more source
Lesch-Nyhan Syndrome: Evaluation of a Modified Bite Device to Prevent Bite Injuries
Applied Sciences, 2020 Lesch-Nyhan syndrome (LNS) is a serious form of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency, a hereditary purine metabolism disorder. The prevalence reported in the literature is 1/380,000 to 235,000 births.
Gaetano Ierardo +4 more
doaj +1 more source
Physiological Reports, Volume 13, Issue 15, August 2025.Abstract Pregnancy demands increased food intake and nutrient delivery to support the growing conceptus. The timing and regional specificity of adaptations in small intestinal (SI) anatomy and transport, and their functional consequences, remain unclear. We therefore assessed anatomy and expression of macronutrient transporters in the duodenum, jejunum,
T. Sebastian Overduin +5 more
wiley +1 more source
Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes [PDF]
, 2011 Context: Increased plasma levels of glucose-dependent insulinotropic polypeptide (GIP), calcitonin CT gene-related peptide (CGRP)-I, and procalcitonin (Pro-CT) are associated with obesity.
Christ-Crain, Mirjam +10 more
core +1 more source
FEBS Open Bio, Volume 15, Issue 7, Page 1054-1067, July 2025.ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren +8 more
wiley +1 more source