Hypoxia-Induced Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Is Regulated by Caveolin-1-Dependent Adenosine Monophosphate-Activated Protein Kinase Activity [PDF]
Purpose Adenosine monophosphate-activated protein kinase (AMPK) is thought to inhibit cell proliferation or promote cell death, but the details remain unclear.
Tae Jin Cho+4 more
doaj +1 more source
Contribution of collagen XIII to lung function and development of pulmonary fibrosis
Background Collagen XIII is a transmembrane collagen associated with neuromuscular junction development, and in humans its deficiency results in congenital myasthenic syndrome type 19 (CMS19), which leads to breathing difficulties. CMS19 patients usually
Riitta Kaarteenaho+7 more
doaj +1 more source
Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences [PDF]
Background: Intrauterine growth restriction is associated with an increased future risk for developing cardiovascular diseases. Hypoxia in utero is a common clinical cause of fetal growth restriction.
AM Katz+62 more
core +21 more sources
Abdominal Aortic Occlusion and the Inflammatory Effects in Heart and Brain
Background. Abdominal aortic occlusion (AAO) occurs frequently and causes ischemia/reperfusion (I/R) injury to distant organs. In this study, we aimed to investigate whether AAO induced I/R injury and subsequent damage in cardiac and neurologic tissue ...
Jun Xu+9 more
doaj +1 more source
Background: Athletes often experience poor sleep quality due to stress, altitude exposure, travel across different time zones, and pre-competition nervousness.
Felix Willmer+5 more
doaj +1 more source
Divergent mutational processes distinguish hypoxic and normoxic tumours. [PDF]
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific ...
Bhandari, Vinayak+4 more
core +1 more source
The CMS19 disease model specifies a pivotal role for collagen XIII in bone homeostasis
Mutations in the COL13A1 gene result in congenital myasthenic syndrome type 19 (CMS19), a disease of neuromuscular synapses and including various skeletal manifestations, particularly facial dysmorphisms. The phenotypic consequences in Col13a1 null mice (
A. V. Kemppainen+8 more
doaj +1 more source
The Somatotropic Axis in the Sleep Apnea-Obesity Comorbid Duo
Background: Growth hormone (GH) stimulates the production of insulin-like growth factor 1 (IGF-1) in most tissues and together GH and IGF-1 profoundly impact adipose tissue deposition, glucose metabolism and cardiovascular function.
Louis-Marie Galerneau+8 more
doaj +1 more source
Metabolism of asymmetric dimethylarginine in hypoxia: from bench to bedside
Acute hypoxia and chronic hypoxia induce pulmonary vasoconstriction. While hypoxic pulmonary vasoconstriction is a physiological response if parts of the lung are affected, global exposure to hypoxic conditions may lead to clinical conditions like high ...
Juliane Hannemann+3 more
doaj +1 more source
Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing.
Guillermo A. Martínez-Nieto+20 more
doaj +1 more source