Results 1 to 10 of about 927,905 (356)

Hypoxia-Induced Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Is Regulated by Caveolin-1-Dependent Adenosine Monophosphate-Activated Protein Kinase Activity [PDF]

International Neurourology Journal, 2021
Purpose Adenosine monophosphate-activated protein kinase (AMPK) is thought to inhibit cell proliferation or promote cell death, but the details remain unclear.
Tae Jin Cho, Da-Hyun Lee, Bo-Hwa Choi, Helen K. Shinn, Chang-Shin Park   +4 more
doaj   +1 more source

Contribution of collagen XIII to lung function and development of pulmonary fibrosis

BMJ Open Respiratory Research, 2023
Background Collagen XIII is a transmembrane collagen associated with neuromuscular junction development, and in humans its deficiency results in congenital myasthenic syndrome type 19 (CMS19), which leads to breathing difficulties. CMS19 patients usually
Riitta Kaarteenaho, Oula Norman, Jarkko Koivunen, Antti M Salo, Joni M Mäki, Johanna Myllyharju, Taina Pihlajaniemi, Anne Heikkinen   +7 more
doaj   +1 more source

Abdominal Aortic Occlusion and the Inflammatory Effects in Heart and Brain

Mediators of Inflammation, 2023
Background. Abdominal aortic occlusion (AAO) occurs frequently and causes ischemia/reperfusion (I/R) injury to distant organs. In this study, we aimed to investigate whether AAO induced I/R injury and subsequent damage in cardiac and neurologic tissue ...
Jun Xu, Sijie Li, Alexandra Wehbe, Xunming Ji, Yong Yang, Yu Yang, Linhui Qin, Feng-Yong Liu, Yuchuan Ding, Changhong Ren   +9 more
doaj   +1 more source

Generation of human embryonic stem cell lines (WAe001-A-67,WAe001-A-68) with TEAD1 and TEAD4 expression by the PiggyBac transposon system

Stem Cell Research, 2021
Transcription factors TEAD1 and TEAD4 play an important role in development, differentiation, cell growth and proliferation. To further understand the exact role of TEAD1 and TEAD4 in these processes.
Yingyi Quan, Peifeng Jin, Jianshe Ma, Jiwen Yang, Zuxuan Wang, Huan Zhang, Minjie Hu, Junming Fan, Xiaofang Fan, Yongsheng Gong, Ming Li, Yongyu Wang   +11 more
doaj   +1 more source

Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences [PDF]

, 2009
Background: Intrauterine growth restriction is associated with an increased future risk for developing cardiovascular diseases. Hypoxia in utero is a common clinical cause of fetal growth restriction.
AM Katz, AN Tintu, Andrei Tintu, Anne Cathrine Staff, Arnold Schwartz, Asif Ahmed, BO Verburg, C Holubarsch, CP Leeson, DE Stewart, DJ Barker, E Villamor, EA Dumont, Edgar Hernandez-Andrade, Eduard Gratacos, Ellen Rouwet, Erdal Safak, EV Rouwet, Fatima Crispi, Ferdinand le Noble, FJ Giordano, G Pardi, H Haase, H Sugimoto, HQ Miao, I Shiojima, Ingo Morano, Irene Cetin, J Schaper, JL Morrison, Joep Brinkmann, JR Ingelfinger, KH Nicolaides, L Miquerol, L van Heerebeek, Leo Hofstra, M Feucht, M Ream, Marc Tjwa, Marc van Bilsen, Michael Jacobs, MR Zile, MR Zile, MW Gillman, N Ferrara, P Carmeliet, Peter Carmeliet, R Tatsumi, S Gupta, S Hein, S Hein, S Louey, SF Nagueh, Shakil Ahmad, SK Sharma, Stefan Verlohren, TA Fong, TM Nosek, Wouter H. Lamers, X Yue, Y Dor, Y Sugishita, Y Wu   +62 more
core   +16 more sources

Generation of a human embryonic stem cell (WAe001-A-47) with hVGLL4 doxycyclin-inducible expression by the PiggyBac transposon system

Stem Cell Research, 2021
VGLL4 is a new component of the Hippo pathway and bind TEADs to compete with YAP, so as to inhibit tumor progression, but its role in stem cell and organ regeneration remains unclear. Using the PiggyBac transposon system, we generated a VGLL4 doxycycline-
Yingyi Quan, Tianci Zhang, Huan Zhang, Jiwen Yang, Peifeng Jin, Jianshe Ma, Yanyan Fan, Junming Fan, Xiaofang Fan, Yongsheng Gong, Ming Li, Yongyu Wang   +11 more
doaj   +1 more source

Protocol for inducible piggyBac transposon system for efficient gene overexpression in human pluripotent stem cells

STAR Protocols, 2022
Summary: In human pluripotent stem cells (hPSCs), traditional approaches for gene overexpression have low efficiency and are often laborious. Here, we provide a relatively simple protocol for gene overexpression with the Dox-inducible PiggyBac transposon
Jiwen Yang, Minjie Hu, Yongyu Wang
doaj   +1 more source

Divergent mutational processes distinguish hypoxic and normoxic tumours. [PDF]

, 2020
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific ...
Bhandari, Vinayak, Boutros, Paul C, Bristow, Robert G, Li, Constance H, PCAWG Consortium   +4 more
core   +1 more source

Generation of human induced pluripotent stem cell line (WMUi001-A) from a patient with aortic dissection

Stem Cell Research, 2020
A human induced pluripotent stem cell (hiPSC) line (WMUi001-A) was generated from the aortic tissue of a 47-year-old donor with aortic dissection and normal blood pressure.
Peifeng Jin, Sixian Wang, Xu Jiang, Xiaoqiong Shan, Sheng Jiang, Yingyi Quan, Tianci Zhang, Jiwen Yang, Huang Zhang, Jianshe Ma, Miaowu Dong, Junming Fan, Xiaofang Fan, Yongsheng Gong, Yongyu Wang   +14 more
doaj   +1 more source

The Effects of Napping on Wakefulness and Endurance Performance in Athletes: A Randomized Crossover Study

Life, 2023
Background: Athletes often experience poor sleep quality due to stress, altitude exposure, travel across different time zones, and pre-competition nervousness.
Felix Willmer, Claire Reuter, Stephan Pramsohler, Martin Faulhaber, Anja Burkhardt, Nikolaus Netzer   +5 more
doaj   +1 more source