Results 1 to 10 of about 956,013 (356)
Novel mechanism of neuronal hypoxia response: HIF-1α/STOML2 mediated PINK1-dependent mitophagy activation against neuronal injury [PDF]
Cell Death DiscoveryHypoxic stress contributes to brain disorders by causing neuronal injury, making it crucial to understand neuronal hypoxic response mechanisms for disease resistance.
Yuning Li +9 more
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Hypoxia-Induced Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Is Regulated by Caveolin-1-Dependent Adenosine Monophosphate-Activated Protein Kinase Activity [PDF]
International Neurourology Journal, 2021 Purpose Adenosine monophosphate-activated protein kinase (AMPK) is thought to inhibit cell proliferation or promote cell death, but the details remain unclear.
Tae Jin Cho +4 more
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Sestrin2 in hypoxia and hypoxia-related diseases [PDF]
Redox Report, 2021 Objectives: Sestrin2 is a stress-inducible protein and play an important role in adapting stress states of cells. This article reviewed the role of Sestrin2 in hypoxia and hypoxia-related diseases to provide new perspectives for future research and new therapeutic targets for hypoxia-related diseases.Methods: A review was conducted through an ...
Xiaojing Che +7 more
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Contribution of collagen XIII to lung function and development of pulmonary fibrosis
BMJ Open Respiratory Research, 2023 Background Collagen XIII is a transmembrane collagen associated with neuromuscular junction development, and in humans its deficiency results in congenital myasthenic syndrome type 19 (CMS19), which leads to breathing difficulties. CMS19 patients usually
Riitta Kaarteenaho +7 more
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Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function [PDF]
Arthritis Research & Therapy, 2009 With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies.
Walmsley, SR, Chilvers, ER, Whyte, MKB
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Abdominal Aortic Occlusion and the Inflammatory Effects in Heart and Brain
Mediators of Inflammation, 2023 Background. Abdominal aortic occlusion (AAO) occurs frequently and causes ischemia/reperfusion (I/R) injury to distant organs. In this study, we aimed to investigate whether AAO induced I/R injury and subsequent damage in cardiac and neurologic tissue ...
Jun Xu +9 more
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Stem Cell Research, 2021 Transcription factors TEAD1 and TEAD4 play an important role in development, differentiation, cell growth and proliferation. To further understand the exact role of TEAD1 and TEAD4 in these processes.
Yingyi Quan +11 more
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Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis [PDF]
Cells, 2021 Liver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as the net result of liver fibrogenesis, a dynamic and highly integrated process occurring during chronic liver injury of any etiology.
Foglia Beatrice +6 more
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HYPOXIA AND REPRODUCTIVE HEALTH: Hypoxia and labour [PDF]
Reproduction, 2021 Intermittent myometrial hypoxia is a normal feature of labour, as the powerful contractions compress blood vessels. In this review, we focus on the relation between hypoxia, myometrial metabolism, and contractility. We dissect how hypoxia can feedback and limit an ongoing contraction and help prevent foetal distress.
Susan, Wray +2 more
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STAR Protocols, 2022 Summary: In human pluripotent stem cells (hPSCs), traditional approaches for gene overexpression have low efficiency and are often laborious. Here, we provide a relatively simple protocol for gene overexpression with the Dox-inducible PiggyBac transposon
Jiwen Yang, Minjie Hu, Yongyu Wang
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