Results 1 to 10 of about 1,131,072 (401)

Hypoxia-Induced Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Is Regulated by Caveolin-1-Dependent Adenosine Monophosphate-Activated Protein Kinase Activity [PDF]

open access: yesInternational Neurourology Journal, 2021
Purpose Adenosine monophosphate-activated protein kinase (AMPK) is thought to inhibit cell proliferation or promote cell death, but the details remain unclear.
Tae Jin Cho   +4 more
doaj   +1 more source

Contribution of collagen XIII to lung function and development of pulmonary fibrosis

open access: yesBMJ Open Respiratory Research, 2023
Background Collagen XIII is a transmembrane collagen associated with neuromuscular junction development, and in humans its deficiency results in congenital myasthenic syndrome type 19 (CMS19), which leads to breathing difficulties. CMS19 patients usually
Riitta Kaarteenaho   +7 more
doaj   +1 more source

Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences [PDF]

open access: yes, 2009
Background: Intrauterine growth restriction is associated with an increased future risk for developing cardiovascular diseases. Hypoxia in utero is a common clinical cause of fetal growth restriction.
AM Katz   +62 more
core   +21 more sources

Abdominal Aortic Occlusion and the Inflammatory Effects in Heart and Brain

open access: yesMediators of Inflammation, 2023
Background. Abdominal aortic occlusion (AAO) occurs frequently and causes ischemia/reperfusion (I/R) injury to distant organs. In this study, we aimed to investigate whether AAO induced I/R injury and subsequent damage in cardiac and neurologic tissue ...
Jun Xu   +9 more
doaj   +1 more source

The Effects of Napping on Wakefulness and Endurance Performance in Athletes: A Randomized Crossover Study

open access: yesLife, 2023
Background: Athletes often experience poor sleep quality due to stress, altitude exposure, travel across different time zones, and pre-competition nervousness.
Felix Willmer   +5 more
doaj   +1 more source

Divergent mutational processes distinguish hypoxic and normoxic tumours. [PDF]

open access: yes, 2020
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific ...
Bhandari, Vinayak   +4 more
core   +1 more source

The CMS19 disease model specifies a pivotal role for collagen XIII in bone homeostasis

open access: yesScientific Reports, 2022
Mutations in the COL13A1 gene result in congenital myasthenic syndrome type 19 (CMS19), a disease of neuromuscular synapses and including various skeletal manifestations, particularly facial dysmorphisms. The phenotypic consequences in Col13a1 null mice (
A. V. Kemppainen   +8 more
doaj   +1 more source

The Somatotropic Axis in the Sleep Apnea-Obesity Comorbid Duo

open access: yesFrontiers in Endocrinology, 2020
Background: Growth hormone (GH) stimulates the production of insulin-like growth factor 1 (IGF-1) in most tissues and together GH and IGF-1 profoundly impact adipose tissue deposition, glucose metabolism and cardiovascular function.
Louis-Marie Galerneau   +8 more
doaj   +1 more source

Metabolism of asymmetric dimethylarginine in hypoxia: from bench to bedside

open access: yesPulmonary Circulation, 2020
Acute hypoxia and chronic hypoxia induce pulmonary vasoconstriction. While hypoxic pulmonary vasoconstriction is a physiological response if parts of the lung are affected, global exposure to hypoxic conditions may lead to clinical conditions like high ...
Juliane Hannemann   +3 more
doaj   +1 more source

Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis

open access: yesFrontiers in Oncology, 2022
Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing.
Guillermo A. Martínez-Nieto   +20 more
doaj   +1 more source

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