Results 201 to 210 of about 123,337 (240)

ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO‐Mediated N6‐Methyladenosine Demethylation of ACSL1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Microglia play an important role in ischemic stroke (IS). However, the molecular regulatory mechanisms underlying microglial ferroptosis in IS remain incompletely understood. In this study, blood samples were collected from 20 IS patients and 15 healthy volunteers.
Ai‐Xia Song, Han‐Xu Jin, Yuan‐Xin Sun, Wen‐Hui Kou, Xiao‐Ning Niu, Huan‐Huan Wang, Ting‐Ting Zhong, Ping Gu   +7 more
wiley   +1 more source

Novel purine derivatives mitigate hypoxia ischemia related brain injury through agrin, zyxin and synaptotagmin proteins. [PDF]

Neurotherapeutics
Mabondzo A, Disdier C, Bouzid A, Larbi KS, Tsintzou A, Maïza A, Kim B, Costa N, Harati R, Nguyen AL, Pruvost A, Galons H, Oumata N, Armengaud J, Knijnenburg M, Verma G, Hagberg H, Gressens P, Chen XF, Hamoudi RA, Stonestreet BS.   +20 more
europepmc   +1 more source

Efficacy of CPAP Therapy on Liver Steatosis and Insulin Resistance in Fatty Liver Patients With Obstructive Sleep Apnea: A 4‐Year Follow‐Up Cohort Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) and obstructive sleep apnea (OSA) are comorbid conditions that synergistically increase cardiovascular risk through systemic inflammation and insulin resistance. While continuous positive airway pressure (CPAP) is the standard treatment for OSA, its efficacy in improving hepatic ...
Hsiao‐Chin Shen, Yen‐Hsun Huang, Tzu‐Hao Li, Chih‐Hsun Wu, Yu‐Wei Lee, Hsiao‐Yun Yeh, Hung‐Cheng Tsai, Chien‐Wei Su, Kun‐Ta Chou, Ying‐Ying Yang, Ming‐Chih Hou   +10 more
wiley   +1 more source

The Neuroprotective Effects of Caffeine in a Neonatal Hypoxia-Ischemia Model are Regulated through the AMPK/mTOR Pathway. [PDF]

Int J Biol Sci
Bernis ME, Burkard H, Bremer AS, Grzelak K, Zweyer M, Maes E, Nacarkucuk E, Kaibel H, Hakvoort C, Müller A, Sabir H.   +10 more
europepmc   +1 more source

Vaccarin Improves Myocardial Ischemia–Reperfusion Injury by Attenuating Oxidative Stress and Ferroptosis Through Reducing NOX4‐Modulated JAK2/STAT3 Pathway Activation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Vaccarin is a naturally occurring flavonoid glycoside with cardioprotective properties; however, its involvement in myocardial ischemia–reperfusion (MI/R) injury remains poorly defined. We herein investigated whether vaccarin protects cardiomyocytes from MI/R‐induced dysfunction in vivo and in vitro and examined the associated molecular ...
Han Yang, Mi Zhou, Feng‐Cai Zhang
wiley   +1 more source

Neuroprotective Effect of Melatonin in a Neonatal Hypoxia-Ischemia Rat Model Is Regulated by the AMPK/mTOR Pathway. [PDF]

J Am Heart Assoc
Nacarkucuk E, Bernis ME, Bremer AS, Grzelak K, Zweyer M, Maes E, Burkard H, Sabir H.   +7 more
europepmc   +1 more source

Proteomic and Metabolomic Profiling Reveal Mitochondrial Transplantation–Mediated Reprogramming in Gastric Cancer Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen, Chen‐Kai Liu, Ching‐Chung Tsai, Erna Sulistyowati, Fu‐An Li, Chung‐Jung Liu, Deng‐Chyang Wu, Shih‐Hsuan Chou, Fu‐Chen Kuo, Bin Huang   +9 more
wiley   +1 more source

Shared genetic features inference among hypoxia-ischemia diseases in the presence of heterogenous omics data based on a novel risk assessment method. [PDF]

Front Genet
Zhang Y, Liu J, Basang Z, Yang Q, Chen H, Chen S, Li S, Lei C, Fang M, Liu H, Jin X, Wang Y.   +11 more
europepmc   +1 more source

Modified Sleep Apnea Severity Index and Cardiovascular Risk in CPAP‐Intolerant OSA Patients

The Laryngoscope, EarlyView.
The modified sleep apnea severity index (mSASI) combines patient anatomy, weight, sleep study metrics, and symptoms into a composite OSA index ranging from 1 (least severe) to 3 (most severe). Our study found that mSASI correlated better with baseline cardiovascular risk measured by the 5‐year Framingham Risk Score compared to the AHI.
Praneet C. Kaki, Jennifer A. Goldfarb, Melissa Xu, Daniel J. Campbell, Nicole Molin, Erin Creighton, Thomas M. Kaffenberger, Maurits Boon, Colin Huntley   +8 more
wiley   +1 more source

Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia. [PDF]

Stroke
Mike JK, White Y, Ha J, Iranmahboub A, Hawkins C, Hutchings RS, Vento C, Manzoor H, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E.   +16 more
europepmc   +1 more source