Results 101 to 110 of about 122,157 (267)

A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery

, 2008
Background: Several human pathologies, including neoplasia and ischemic cardiovascular diseases, course with an unbalance between oxygen supply and demand ( hypoxia).
Alcaide-German, ML, Del Peso, L, Garcia-Fernandez, LF, Vara-Vega, A, Landazuri, MO   +4 more
core  

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Inflammatory Responses of Hypoxia-Inducible Factor 1α (HIF-1α) in T Cells Observed in Development of Vascular Remodeling

Journal of Pharmacological Sciences, 2011
Recent studies have shown that the cellular immune response to the hypoxic microenvironment constructed by vascular remodeling development modulates the resulting pathologic alterations.
Shuhei Tomita, Yoshitaka Kihira, Masaki Imanishi, Yayoi Fukuhara, Yuko Imamura, Keisuke Ishizawa, Yasumasa Ikeda, Koichiro Tsuchiya, Toshiaki Tamaki   +8 more
doaj   +1 more source

Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation [PDF]

, 2018
Heavy menstrual bleeding (HMB) is common and debilitating, and often requires surgery due to hormonal side effects from medical therapies. Here we show that transient, physiological hypoxia occurs in the menstrual endometrium to stabilise hypoxia ...
Critchley, Hilary O. D., Saunders, Philippa T K, Jacqueline A. Maybin, Hirani, Nikhil, Murray, Alison A., Hilary O. D. Critchley, Saunders, Philippa T. K.; id_orcid, Peter Carmeliet, Philippa T. K. Saunders, Maybin, Jacqueline A, Murray, Alison A, Alison A. Murray, Nikhil Hirani, Critchley, Hilary O D, Carmeliet, Peter, Maybin, Jacqueline A.   +15 more
core   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis

Frontiers in Pharmacology, 2017
Fibrosis, characterized by increased extracellular matrix (ECM) deposition, and widespread vasculopathy, has the prominent trait of chronic hypoxia. Hypoxia inducible factors-1α (HIF-1α), a key transcriptional factor in response to this chronic hypoxia ...
Anji Xiong, Yi Liu
doaj   +1 more source

Bubble Formation Control: Fabrication of Centimeter‐Sized Tissue‐Like Constructs by Catalase‐Coated Oxygen‐Releasing Hydrogel

Advanced Materials, EarlyView.
Oxygen‐releasing hydrogels are widely used to support cell survival in 3D cultures and to promote wound healing. However, incorporating catalase to convert H2O2 into O2 often generates additional oxygen bubbles, leading to material instability which rarely addressed.
Sukulya Bunuasunthon, Isabel F. Amaral, Ana P. Pêgo, Michiya Matsusaki   +3 more
wiley   +1 more source

Supplemental_table_primer_v2_120517 - Hypoxia Induces Hypoxia-Inducible Factor 1α and Potential HIF-Responsive Gene Expression in Uterine Leiomyoma

, 2018
Supplemental_table_primer_v2_120517 for Hypoxia Induces Hypoxia-Inducible Factor 1α and Potential HIF-Responsive Gene Expression in Uterine Leiomyoma by Hiroshi Ishikawa, Linlin Xu, Kunizui Sone, Tatsuya Kobayashi, Guiwen Wang, and Makio Shozu in ...
Hiroshi Ishikawa (282324), Kunizui Sone (5240540), Makio Shozu (32265), Linlin Xu (517198), Tatsuya Kobayashi (29608), Guiwen Wang (5240537)   +5 more
core   +1 more source

A Reproducible and Scalable Process for High Yield Mesenchymal Stromal Cell Extracellular Vesicles Production

Advanced Materials Technologies, EarlyView.
Mesenchymal stem cell derived extracellular vesicles (MSC‐EVs) are a promising therapeutic tool for regenerative medicine. However, the field lacks a reproducible high‐yield production method to answer the quantities needed for clinical translation.
Christophe Wong, Elise Madec, Jeanne Volatron, Max Piffoux, Amanda K. A. Silva, Florence Gazeau, Jean‐Philippe Herbeuval, Thibaut Fourniols   +7 more
wiley   +1 more source

Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium

, 2016
Airway epithelial CD55 down-regulation occurs in several hypoxia-associated pulmonary diseases, but the mechanism is unknown. Using in vivo and in vitro assays of pharmacologic inhibition and gene silencing, the current study investigated the role of ...
Gracon, Adam, Sandusky, George E., Pollok, Karen, Renbarger, Jamie, Pandya, Pankita H., Blum, Janice S., Murray, Mary, Lahm, Tim, Fisher, Amanda J., Temm, Constance J., Rothhaar, Katia, Lipking, Kelsey P., Mickler, Elizabeth A., Wilkes, David S.   +13 more
core   +1 more source