Results 101 to 110 of about 180,302 (314)

HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma [PDF]

, 2016
Indexación: Web of ScienceBackground: Class I histone deacetylases (HDACs) have been reported to be overexpressed in clear cell renal cell carcinoma (ccRCC), whereas the expression of class II HDACs is unknown.
Attwood, Kris, Chintala, Sreenivasulu, Ciamporcero, Eric, Conroy, Dylan, Das, Gokul, Ellis, Leigh, Huang, Ray, Ku, ShengYu, Miles, Kiersten Marie, Orillion, Ashley, Pili, Roberto, Ramakrishnan, Swathi, Shen, Li, Sotomayor, Paula, Swetzig, Wendy   +14 more
core   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]

, 2015
Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Abooali, Maryam, Berger, Steffen M., Casely-Hayford, Maxwell A., Fasler-Kan, Elizaveta, Gibbs, Bernhard F., Gonçalves Silva, Isabel, Prokhorov, Alexandr, Sumbayev, Vadim V., Yasinska, Inna M.   +8 more
core   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Effects of acute hypoxia exposure with different durations on activation of Nrf2-ARE pathway in mouse skeletal muscle.

PLoS ONE, 2018
BackgroundHypoxia training enhances the endurance capacity of athletes. This response may in part be attributed to the hypoxia-induced increase in antioxidant capacity in skeletal muscles.
Weixiu Ji, Linjia Wang, Shiyi He, Lu Yan, Tieying Li, Jianxiong Wang, Ah-Ng Tony Kong, Siwang Yu, Ying Zhang   +8 more
doaj   +1 more source

mRNA expression profile of selected oxygen sensing genes in the lung during recovery from chronic hypoxia

Biological Research, 2013
This study analyzed the time dependence decay of the mRNA of selected genes important for the hypoxia response. The genes chosen were the two isoforms of hypoxia-inducible factors, the three isoforms of the prolyl hydroxylase domain protein, the vascular
Alice Panariti, Giuseppe Miserocchi, Ilaria Rivolta   +2 more
doaj   +1 more source

Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. [PDF]

PLoS ONE, 2014
The transcriptional response promoted by hypoxia-inducible factors has been associated with metastatic spread of uveal melanoma. We found expression of hypoxia-inducible factor 1α (HIF-1α) protein in well-vascularized tumor regions as well as in four ...
Laura Asnaghi, Michael H Lin, Kah Suan Lim, Kah Jing Lim, Arushi Tripathy, Murilo Wendeborn, Shannath L Merbs, James T Handa, Akrit Sodhi, Eli E Bar, Charles G Eberhart   +10 more
doaj   +1 more source

Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α [PDF]

, 2012
Increased levels of hypoxia and hypoxia-inducible factor 1α (HIF-1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged antiangiogenic therapy of tumors not only delays tumor growth but may also increase hypoxia and ...
Eisinger-Mathason, TS Karin, Karl, Daniel L, Kim, Tae-Min, Kim, Yeo-Jung, Lee, Hae-June, Nakazawa, Michael S, Park, Peter J, Schmidt, Benjamin, Simon, M Celeste, Yoon, Sam S, Zhang, Alexia Y   +10 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source