Results 101 to 110 of about 4,389,282 (265)

ILKAP Binding to and Dephosphorylating HIF-1α is Essential for Apoptosis Induced by Severe Hypoxia

Cellular Physiology and Biochemistry, 2018
Background/Aims: Integrin-linked kinase-associated phosphatase (ILKAP), a serine/threonine phosphatase that belongs to the protein phosphatase 2C family, has a role in cell survival and apoptosis.
Tielong Liu, Yonggang Liu, Jiashi Cao, Xin Gao, Jing Wang, Guanghui Chen, Yang Wang, Ge Liu, Guangjian Bai, Yiwei Hu, Jiaxiang Yang, Lianfeng Dong, Xinbao Quan, Weiwei Zou   +13 more
doaj   +1 more source

Negative regulation of hypoxia inducible factor-1α by necdin [PDF]

, 2005
Hypoxia-inducible factor 1 (HIF-1) is a master transcription factor that mediates cellular and systemic homeostatic responses to reduce O2 availability, such as erythropoiesis, angiogenesis, and glycolysis. Using the yeast two-hybrid screening system, we
Jeong Ae Park, Park, Jeong Ae, Min, Kyung-Jin, Kwon, Yoo-Wook, Moon, Hyo-Eun, Kim, Kyu-Won, Hyo-Eun Moon, Mee-Young Ahn, Kyung-Jin Min, Kyu-Won Kim, Yoo-Wook Kwon, Ahn, Mee-Young   +11 more
core   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Inflammatory Responses of Hypoxia-Inducible Factor 1α (HIF-1α) in T Cells Observed in Development of Vascular Remodeling

Journal of Pharmacological Sciences, 2011
Recent studies have shown that the cellular immune response to the hypoxic microenvironment constructed by vascular remodeling development modulates the resulting pathologic alterations.
Shuhei Tomita, Yoshitaka Kihira, Masaki Imanishi, Yayoi Fukuhara, Yuko Imamura, Keisuke Ishizawa, Yasumasa Ikeda, Koichiro Tsuchiya, Toshiaki Tamaki   +8 more
doaj   +1 more source

Supplementary Figure 1 from Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α Are Expressed in Kaposi Sarcoma and Modulated by Insulin-like Growth Factor-I

, 2006
Supplementary Figure 1 from Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α Are Expressed in Kaposi Sarcoma and Modulated by Insulin-like Growth Factor-
Anca Irinel Catrina (14980252), Sergiu-Bogdan Catrina (437365), Lorenz Poellinger (216343), Kerstin Brismar (135185), Pawan Pyakurel (79865), Octavian Savu (14980255), Magnus Axelson (227628), Peter Biberfeld (79867), Ileana Ruxandra Botusan (4955797), Anja Rantanen (14980249)   +9 more
core   +1 more source

Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation [PDF]

, 2018
Heavy menstrual bleeding (HMB) is common and debilitating, and often requires surgery due to hormonal side effects from medical therapies. Here we show that transient, physiological hypoxia occurs in the menstrual endometrium to stabilise hypoxia ...
Critchley, Hilary O. D., Saunders, Philippa T K, Jacqueline A. Maybin, Hirani, Nikhil, Murray, Alison A., Hilary O. D. Critchley, Saunders, Philippa T. K.; id_orcid, Peter Carmeliet, Philippa T. K. Saunders, Maybin, Jacqueline A, Murray, Alison A, Alison A. Murray, Nikhil Hirani, Critchley, Hilary O D, Carmeliet, Peter, Maybin, Jacqueline A.   +15 more
core   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis

Frontiers in Pharmacology, 2017
Fibrosis, characterized by increased extracellular matrix (ECM) deposition, and widespread vasculopathy, has the prominent trait of chronic hypoxia. Hypoxia inducible factors-1α (HIF-1α), a key transcriptional factor in response to this chronic hypoxia ...
Anji Xiong, Yi Liu
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

Advanced Materials, EarlyView.
This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris, Sangho Lee, Kalp Soni, Simon He, Matthew Huang, Dandan Chen, Dae Hoon Lee, Kyung Hee Kim, Seonggeon Cho, Laura Pencea, Divit Jain, Young‐Sup Yoon   +11 more
wiley   +1 more source