Results 131 to 140 of about 180,302 (314)

MicroRNA‐34a‐Dependent Attenuation of Angiogenesis in Right Ventricular Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The right ventricle (RV) is at risk in patients with complex congenital heart disease involving right‐sided obstructive lesions. We have shown that capillary rarefaction occurs early in the pressure‐loaded RV.
Sushma Reddy, Dong‐Qing Hu, Mingming Zhao, Shoko Ichimura, Elizabeth A. Barnes, David N. Cornfield, Miguel A. Alejandre Alcázar, Edda Spiekerkoetter, Giovanni Fajardo, Daniel Bernstein   +9 more
doaj   +1 more source

Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma [PDF]

, 2016
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. We previously showed that the inhibition of placental growth factor (PlGF) exerts antitumour effects and induces vessel normalisation, possibly reducing hypoxia ...
Bogaerts, Eliene, Carmeliet, Peter, Devisscher, Lindsey, Geerts, Anja, Jonckx, Bart, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van den Bussche, Anja, Van Steenkiste, Christophe, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Verhelst, Xavier   +13 more
core   +1 more source

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

Frontiers in Oncology, 2017
Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and nutrient-deprived environment and drives progression to malignancy in human solid cancers. Its canonical regulation involves prolyl hydroxylases (PHDs), which in
Luisa Iommarini, Anna Maria Porcelli, Giuseppe Gasparre, Ivana Kurelac   +3 more
doaj   +1 more source

Fifteen days of 3200m simulated hypoxia marginally regulates markers for protein synthesis and degradation in human skeletal muscle [PDF]

, 2016
Chronic hypoxia leads to muscle atrophy. The molecular mechanisms responsible for this phenomenon are not well defined in vivo. We sought to determine how chronic hypoxia regulates molecular markers of protein synthesis and degradation in human skeletal ...
Bertrand, L, Bishop, David, D'Hulst, G, Deldique, L, Ferri, Alessandra, Francaux, M, Horman, S, Naslain, D   +7 more
core   +2 more sources

Laser‐Assisted Processing and Modification of Bioactive Glasses: A Review

Advanced Healthcare Materials, EarlyView.
Laser technologies provide powerful tools to process and transform bioactive glasses for advanced biomedical applications. This review discusses laser‐matter interaction mechanisms, laser surface engineering, and laser‐assisted fabrication of scaffolds and nanofibers.
Antonio Riveiro, Mario González‐Quintas, Mónica Fernández‐Arias, Jesús del Val, Félix Quintero, Rafael Comesaña, Fernando Lusquiños, Julian R. Jones, Juan Pou   +8 more
wiley   +1 more source

ILKAP Binding to and Dephosphorylating HIF-1α is Essential for Apoptosis Induced by Severe Hypoxia

Cellular Physiology and Biochemistry, 2018
Background/Aims: Integrin-linked kinase-associated phosphatase (ILKAP), a serine/threonine phosphatase that belongs to the protein phosphatase 2C family, has a role in cell survival and apoptosis.
Tielong Liu, Yonggang Liu, Jiashi Cao, Xin Gao, Jing Wang, Guanghui Chen, Yang Wang, Ge Liu, Guangjian Bai, Yiwei Hu, Jiaxiang Yang, Lianfeng Dong, Xinbao Quan, Weiwei Zou   +13 more
doaj   +1 more source

Endothelial progenitor cells and burn injury - exploring the relationship. [PDF]

, 2016
Burn wounds result in varying degrees of soft tissue damage that are typically graded clinically. Recently a key participant in neovascularization, the endothelial progenitor cell, has been the subject of intense cardiovascular research to explore ...
Adnani, Blake O, Araniego, Cheryl Ann, Banyard, Derek A, Melkumyan, Satenik, Widgerow, Alan D   +4 more
core   +2 more sources

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Inflammatory Responses of Hypoxia-Inducible Factor 1α (HIF-1α) in T Cells Observed in Development of Vascular Remodeling

Journal of Pharmacological Sciences, 2011
Recent studies have shown that the cellular immune response to the hypoxic microenvironment constructed by vascular remodeling development modulates the resulting pathologic alterations.
Shuhei Tomita, Yoshitaka Kihira, Masaki Imanishi, Yayoi Fukuhara, Yuko Imamura, Keisuke Ishizawa, Yasumasa Ikeda, Koichiro Tsuchiya, Toshiaki Tamaki   +8 more
doaj   +1 more source