Results 281 to 290 of about 180,302 (314)

Hypoxia inducible factor-1α drives cancer resistance to cuproptosis.

Cancer Cell
Cuproptosis represents a new type of cell death that intricately associated with copper homeostasis and protein lipoylation. The cuproptosis suppression has been characterized in the hypoxic tumor microenvironment (TME).
Zhou Yang   +25 more
semanticscholar   +3 more sources

Role of Hypoxia Inducible Factor-1α in Alzheimer’s Disease

Journal of Alzheimer's Disease, 2021
Amyloid-β (Aβ) peptides and hyperphosphorylated tau protein are the most important pathological markers of Alzheimer’s disease (AD). Neuroinflammation and oxidative stress are also involved in the development and pathological mechanism of AD.
Yangyang Wang   +11 more
semanticscholar   +1 more source

Hypoxia Inducible Factor-1α (HIF-1α) Mediates NLRP3 Inflammasome-Dependent-Pyroptotic and Apoptotic Cell Death Following Ischemic Stroke.

Neuroscience, 2020
OBJECTIVES Stroke is a major cause of death and long-term disability. Recent evidence suggests that hypoxia-inducible factor 1α (HIF-1α), a transcription factor that regulates oxygen levels, plays a key role in neurological outcomes after ischemic stroke.
Qian Jiang   +7 more
semanticscholar   +1 more source

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