Results 51 to 60 of about 140,789 (198)

Research progress of hypoxia inducible factor 1α in the mechanism of diabetic kidney disease [PDF]

Jichu yixue yu linchuang
Hypoxia-inducible factor-1α (HIF-1α) is a nuclear transcription factor. Under high glucose and hypoxia conditions, the expression of HIF-1α is elevated, result in the increased expression of its downstream target genes VEGF, HO-1 and BNIP3, which affect ...
ZHANG Yahui, BAI Qiong
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

SCF, regulated by HIF-1α, promotes pancreatic ductal adenocarcinoma cell progression.

PLoS ONE, 2015
Stem cell factor (SCF) and hypoxia-inducible factor-1α (HIF-1α) both have important functions in pancreatic ductal adenocarcinoma (PDAC). This study aims to analyze the expression and clinicopathological significance of SCF and HIF-1α in PDAC specimens ...
Chuntao Gao, Shasha Li, Tiansuo Zhao, Jing Chen, He Ren, Huan Zhang, Xiuchao Wang, Mingxiao Lang, Jingcheng Liu, Song Gao, Xiao Zhao, Jun Sheng, Zhanna Yuan, Jihui Hao   +13 more
doaj   +1 more source

Sirt1–hypoxia‐inducible factor‐1α interaction is a key mediator of tubulointerstitial damage in the aged kidney

Aging Cell, 2019
Although it is known that the expression and activity of sirtuin 1 (Sirt1) decrease in the aged kidney, the role of interaction between Sirt1 and hypoxia‐inducible factor (HIF)‐1α is largely unknown. In this study, we investigated whether HIF‐1α could be
D. Ryu, M. Yu, Kyoung Hye Kong, Hyoungnae Kim, S. Kwon, J. Jeon, D. Han, H. Noh   +7 more
semanticscholar   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy

Cell Death and Disease, 2023
The transcription factor hypoxia-inducible factor-1α (HIF-1α), as a master regulator of adaptive responses to hypoxia, possesses two transcriptional activation domains [TAD, N-terminal (NTAD), and C-terminal (CTAD)].
Zuo-Lin Li, Lin Ding, Rui-Xia Ma, Yue Zhang, Yi-Lin Zhang, Wei-Jie Ni, Tao-Tao Tang, Gui-Hua Wang, Bin Wang, Lin-Li Lv, Qiu-Li Wu, Yi Wen, Bi-Cheng Liu   +12 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Hypoxia-inducible factor 1α inhibitor reduces hippocampal neuronal ferroptosis

Neural Regeneration Research
Epilepsy is a prevalent neurological disorder in which hippocampal neuronal damage, particularly ferroptosis, plays a critical role. Previous studies have shown that hypoxia-inducible factor 1α is considered an important regulator of cellular stress ...
Zhen Liang, Qi Guo, Zhaoshi Zheng, Yingyue Lou, Xiaojuan Zhu, Songyan Liu   +5 more
doaj   +1 more source

Macrophage‐Specific Hypoxia‐Inducible Factor‐1α Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis

Hepatology, 2019
Inflammatory cell activation drives diverse cellular programming during hepatic diseases. Hypoxia‐inducible factors (HIFs) have recently been identified as important regulators of immunity and inflammation.
Xiaojing Wang, Marcelle de Carvalho Ribeiro, Arvin Iracheta-Vellve, Patrick P. Lowe, Aditya Ambade, A. Satishchandran, T. Bukong, D. Catalano, K. Kodys, G. Szabo   +9 more
semanticscholar   +1 more source