Results 221 to 230 of about 136,766 (265)

Hypoxia-Inducible Factor-1 (HIF-1)

Molecular Pharmacology, 2006
Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival. The primary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive transcriptional ...
Qingdong, Ke, Max, Costa
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Hypoxia-Inducible Factor 1 and Preeclampsia: A New Perspective

Current Hypertension Reports, 2022
Preeclampsia (PE) is a serious and distinct type of pregnancy-induced hypertension, with an incidence of 2-8% worldwide. PE is defined as pregnancy-related hypertension with proteinuria and peripheral edema after 20 weeks of gestation. Hypoxic placenta triggers the release of inflammatory and humoral substances into maternal circulation, leading to ...
Albogami, Sarah, Al-Kuraishy, Hayder, Al-Maiahy, Thabat, Al-Buhadily, Ali, Al-Gareeb, Ali, Alorabi, Mohammed, Alotaibi, Saqer, de Waard, Michel, Sabatier, Jean-Marc, Saad, Hebatallah, Batiha, Gaber El-Saber   +10 more
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Hypoxia-inducible factor 1 in autoimmune diseases

Cellular Immunology, 2016
Autoimmune disorders are a complicated and varied group of diseases arising from inappropriate immune responses. Recent studies have demonstrated that ongoing inflammatory and immune responses are associated with increased oxygen consumption, a process resulting in localized tissue hypoxia within inflammatory lesions ("inflammatory hypoxia"), in which ...
Wei, Deng, Xuebing, Feng, Xia, Li, Dandan, Wang, Lingyun, Sun   +4 more
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Regulation of angiogenesis by hypoxia-inducible factor 1

Critical Reviews in Oncology/Hematology, 2006
Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression.
Kiichi, Hirota, Gregg L, Semenza
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Hypoxia‐Inducible Factor 1 Inhibitors

2007
The tremendous progress in our understanding of the molecular mechanisms underlying the presence and consequences of hypoxia in human cancers has been accompanied by renewed enthusiasm for the development of therapeutic strategies targeting hypoxic cells signaling pathways.
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Signal transduction to hypoxia-inducible factor 1

Biochemical Pharmacology, 2002
Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation. HIF-1 activity is regulated by the cellular O2 concentration and by the major growth factor-stimulated signal ...
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Hypoxia-Inducible Factor 1 in Lower Limb Ischemia

Vascular, 2006
In the Western world, peripheral vascular disease (PVD) has a high prevalence and is associated with high morbidity and mortality. More patients are presenting with critical limb ischemia (CLI), the end stage of PVD, because of an increased life expectancy owing to improved medical care. In a large percentage of these patients, lower limb amputation is
Teik K, Ho, David J, Abraham, Carol M, Black, Daryll M, Baker   +3 more
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Regulation of Vascularization by Hypoxia‐Inducible Factor 1

Annals of the New York Academy of Sciences, 2009
Vascularization and vascular remodeling represent critical adaptive responses to tissue hypoxia that are mediated by hypoxia‐inducible factor 1 (HIF‐1). In patients with peripheral arterial disease, these responses are impaired by aging and diabetes, leading to critical limb ischemia and amputation.
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Hypoxia-inducible-factor-1 in trauma and critical care

Journal of Critical Care, 2017
HIF-1 is a ubiquitous signaling molecule constantly expressed by the body, but is degraded during normoxic conditions. In hypoxic conditions, it persists and is active. Hypoxia is often associated with trauma due to interrupted blood flow, inflammation or other reasons, causing HIF-1 to be active in signaling and recovery.
Bogdanovski, Dorian A., DiFazio, Louis T., Bogdanovski, Anastasia K., CsÃ3ka, Balázs, Jordan, Garrett B., Paul, Elina R., Antonioli, Luca, Pilip, Stefanie A., Nemeth, Zoltan H.   +8 more
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Hypoxia-inducible factor 1 (HIF-1) in cancer

European Journal of Surgical Oncology (EJSO), 2004
Hypoxia is a common feature of many cancers. It contributes to local and systemic tumour progression as well as potentially compromising radiotherapy and chemotherapy. Hypoxia-inducible factor 1 (HIF-1) is an essential component in changing the transcriptional response of tumours under hypoxia.
M, Quintero, N, Mackenzie, P A, Brennan
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